Deletion Strain | FD score | P-value | Gene | Gene Description |
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YFL036W | 25.20 | 2.05E-140 | RPO41 | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
YKL139W | 9.64 | 2.74E-22 | CTK1 | Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 |
YBR078W | 9.05 | 7.09E-20 | ECM33 | GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p |
YJL102W | 7.69 | 7.29E-15 | MEF2 | Mitochondrial elongation factor involved in translational elongation |
YPL256C | 7.06 | 8.47E-13 | CLN2 | G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
YFL049W | 7.05 | 8.87E-13 | SWP82 | Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions |
YOR246C | 6.96 | 1.68E-12 | ENV9 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YOR101W | 6.23 | 2.39E-10 | RAS1 | GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress |
YPL138C | 5.61 | 1.03E-8 | SPP1 | Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein |
YPR060C | 5.58 | 1.20E-8 | ARO7 | Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis |
YDR127W | 5.56 | 1.33E-8 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YHR008C | 5.31 | 5.54E-8 | SOD2 | Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated |
YNR037C | 5.26 | 7.09E-8 | RSM19 | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein |
YMR307W | 5.18 | 1.12E-7 | GAS1 | Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery |
YNL084C | 5.08 | 1.93E-7 | END3 | EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p |