Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YPR105C | 8.89 | 3.05E-19 | 2.22 | COG4 | Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YKR068C | 7.62 | 1.25E-14 | 2.22 | BET3 | Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex |
YHR062C | 5.40 | 3.34E-8 | 0.15 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YLR116W | 5.25 | 7.44E-8 | 0.09 | MSL5 | Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA |
YER148W | 5.17 | 1.18E-7 | 0.31 | SPT15 | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
YHR036W | 4.86 | 6.01E-7 | 0.14 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YML031W | 4.71 | 1.22E-6 | 0.42 | NDC1 | Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 |
YPR035W | 4.29 | 8.86E-6 | 0.45 | GLN1 | Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YLR022C | 3.84 | 6.08E-5 | 0.19 | SDO1 | Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes |
YDL004W | 3.65 | 1.30E-4 | 0.05 | ATP16 | Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated |
YDL098C | 3.60 | 1.56E-4 | 0.06 | SNU23 | Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome |
YGL233W | 3.55 | 1.93E-4 | 0.00 | SEC15 | Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase |
YGL099W | 3.55 | 1.96E-4 | 0.40 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YLR115W | 3.15 | 8.28E-4 | 0.01 | CFT2 | Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. |
YBR234C | 3.14 | 8.45E-4 | 0.06 | ARC40 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |