Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR479C | 33.90 | 9.70E-252 | PEX29 | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
YLR324W | 14.00 | 1.26E-44 | PEX30 | Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p |
YDL100C | 9.03 | 8.39E-20 | GET3 | Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress |
YNL145W | 8.66 | 2.36E-18 | MFA2 | Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 |
YMR230W | 7.07 | 7.99E-13 | RPS10B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication |
YOR062C_p | 5.68 | 6.87E-9 | YOR062C_p | Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
YDL065C | 5.58 | 1.20E-8 | PEX19 | Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning |
YOR316C-A_p | 5.37 | 3.93E-8 | YOR316C-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YOL027C | 5.23 | 8.47E-8 | MDM38 | Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome |
YDR209C_d | 5.10 | 1.72E-7 | YDR209C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. |
YBR238C | 4.93 | 4.14E-7 | YBR238C | Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span |
YOL020W | 4.91 | 4.66E-7 | TAT2 | High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance |
YDR329C | 4.68 | 1.43E-6 | PEX3 | Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p |
YHR004C | 4.66 | 1.57E-6 | NEM1 | Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard |
YGR204C-A_p | 4.65 | 1.64E-6 | YGR204C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |