0671-0132

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1259
Screen concentration 43.0 μM
Source ChemDiv (Drug-like library)
PubChem CID
SMILES Cc1cc(ccc1S(=O)(=O)Nc2ccc(Br)cc2)[N+](=O)[O-]
Standardized SMILES Cc1cc(ccc1S(=O)(=O)Nc2ccc(Br)cc2)[N+](=O)[O-]
Molecular weight 371.2064
ALogP 3.45
H-bond donor count 4
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.04
% growth inhibition (Hom. pool) 10.17


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for X1259
Download HIP data (tab-delimited text)  (excel)
Gene:BOS1(YLR078C)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.02||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:BRN1(YBL097W)|FD-Score:3.3|P-value:4.81E-4|Clearance:0.14||SGD DESC:Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission Gene:CDC21(YOR074C)|FD-Score:4.26|P-value:1.00E-5|Clearance:0.11||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:CEF1(YMR213W)|FD-Score:3.74|P-value:9.20E-5|Clearance:0.03||SGD DESC:Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p Gene:ERG1(YGR175C)|FD-Score:3.35|P-value:3.97E-4|Clearance:0.05||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:FCF1(YDR339C)|FD-Score:-3.23|P-value:6.24E-4|Clearance:0||SGD DESC:Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p Gene:MCD4(YKL165C)|FD-Score:5.12|P-value:1.50E-7|Clearance:0.86||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MCM7(YBR202W)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.07||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:NFS1(YCL017C)|FD-Score:-3.57|P-value:1.79E-4|Clearance:0||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PKC1(YBL105C)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.07||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE6(YOL038W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.03||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RPA135(YPR010C)|FD-Score:-3.65|P-value:1.32E-4|Clearance:0||SGD DESC:RNA polymerase I second largest subunit A135 Gene:SEC21(YNL287W)|FD-Score:-4.35|P-value:6.96E-6|Clearance:0||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SPC3(YLR066W)|FD-Score:4.15|P-value:1.64E-5|Clearance:0.39||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 Gene:SPT15(YER148W)|FD-Score:3.16|P-value:7.96E-4|Clearance:0.08||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:SRP21(YKL122C)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm Gene:SSS1(YDR086C)|FD-Score:3.58|P-value:1.73E-4|Clearance:0.15||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:VAS1(YGR094W)|FD-Score:3.76|P-value:8.48E-5|Clearance:0.02||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YGL102C(YGL102C_d)|FD-Score:6.38|P-value:9.09E-11|Clearance:1.25||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Gene:YOR102W(YOR102W_d)|FD-Score:3.61|P-value:1.53E-4|Clearance:0.01||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:BOS1(YLR078C)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.02||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:BRN1(YBL097W)|FD-Score:3.3|P-value:4.81E-4|Clearance:0.14||SGD DESC:Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission Gene:CDC21(YOR074C)|FD-Score:4.26|P-value:1.00E-5|Clearance:0.11||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:CEF1(YMR213W)|FD-Score:3.74|P-value:9.20E-5|Clearance:0.03||SGD DESC:Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p Gene:ERG1(YGR175C)|FD-Score:3.35|P-value:3.97E-4|Clearance:0.05||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:FCF1(YDR339C)|FD-Score:-3.23|P-value:6.24E-4|Clearance:0||SGD DESC:Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p Gene:MCD4(YKL165C)|FD-Score:5.12|P-value:1.50E-7|Clearance:0.86||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MCM7(YBR202W)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.07||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:NFS1(YCL017C)|FD-Score:-3.57|P-value:1.79E-4|Clearance:0||SGD DESC:Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria Gene:PKC1(YBL105C)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.07||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE6(YOL038W)|FD-Score:3.64|P-value:1.38E-4|Clearance:0.03||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RPA135(YPR010C)|FD-Score:-3.65|P-value:1.32E-4|Clearance:0||SGD DESC:RNA polymerase I second largest subunit A135 Gene:SEC21(YNL287W)|FD-Score:-4.35|P-value:6.96E-6|Clearance:0||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SPC3(YLR066W)|FD-Score:4.15|P-value:1.64E-5|Clearance:0.39||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 Gene:SPT15(YER148W)|FD-Score:3.16|P-value:7.96E-4|Clearance:0.08||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:SRP21(YKL122C)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm Gene:SSS1(YDR086C)|FD-Score:3.58|P-value:1.73E-4|Clearance:0.15||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:VAS1(YGR094W)|FD-Score:3.76|P-value:8.48E-5|Clearance:0.02||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YGL102C(YGL102C_d)|FD-Score:6.38|P-value:9.09E-11|Clearance:1.25||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Gene:YOR102W(YOR102W_d)|FD-Score:3.61|P-value:1.53E-4|Clearance:0.01||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for X1259
Download HOP data (tab-delimited text)  (excel)
Gene:ADE1(YAR015W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress Gene:AGX1(YFL030W)|FD-Score:4.96|P-value:3.57E-7||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:AHC2(YCR082W)|FD-Score:3.34|P-value:4.17E-4||SGD DESC:Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex Gene:AIM24(YJR080C)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss Gene:ARN2(YHL047C)|FD-Score:-3.34|P-value:4.16E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:BFA1(YJR053W)|FD-Score:-3.98|P-value:3.51E-5||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:BFR1(YOR198C)|FD-Score:3.47|P-value:2.55E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:BOI2(YER114C)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:CHL1(YPL008W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome Gene:CNA1(YLR433C)|FD-Score:-3.9|P-value:4.71E-5||SGD DESC:Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 Gene:CUL3(YGR003W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 Gene:DGR1(YNL130C-A_p)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose Gene:EAF3(YPR023C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:EAP1(YKL204W)|FD-Score:-4.52|P-value:3.12E-6||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:EAR1(YMR171C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p Gene:EMC1(YCL045C)|FD-Score:4.43|P-value:4.73E-6||SGD DESC:Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 Gene:EMC5(YIL027C)|FD-Score:-3.4|P-value:3.36E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT Gene:ERG4(YGL012W)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol Gene:ERG5(YMR015C)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERP1(YAR002C-A)|FD-Score:4.26|P-value:1.00E-5||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:ERV25(YML012W)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport Gene:EST3(YIL009C-A)|FD-Score:-3.4|P-value:3.35E-4||SGD DESC:Component of the telomerase holoenzyme, involved in telomere replication Gene:FES1(YBR101C)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FIG4(YNL325C)|FD-Score:-3.16|P-value:7.87E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:FLC2(YAL053W)|FD-Score:4.47|P-value:3.97E-6||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FMO1(YHR176W)|FD-Score:-4.66|P-value:1.58E-6||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FOX2(YKR009C)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:FUR4(YBR021W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:GCN20(YFR009W)|FD-Score:3.81|P-value:6.93E-5||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GTO1(YGR154C)|FD-Score:4.75|P-value:1.03E-6||SGD DESC:Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization Gene:GYL1(YMR192W)|FD-Score:3.92|P-value:4.38E-5||SGD DESC:Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HIR1(YBL008W)|FD-Score:3.3|P-value:4.75E-4||SGD DESC:Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores Gene:HRK1(YOR267C)|FD-Score:-3.15|P-value:8.19E-4||SGD DESC:Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress Gene:HSL7(YBR133C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:IMG2(YCR071C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IRC4(YDR540C)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:IRC7(YFR055W_p)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner Gene:JEM1(YJL073W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 Gene:MFA1(YDR461W)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MIG3(YER028C)|FD-Score:3.86|P-value:5.78E-5||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRPL16(YBL038W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL23(YOR150W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPL4(YBR170C)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) Gene:NRG2(YBR066C)|FD-Score:-3.33|P-value:4.31E-4||SGD DESC:Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication Gene:OM45(YIL136W)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress Gene:OPI3(YJR073C)|FD-Score:-4.33|P-value:7.31E-6||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PAU13(YHL046C)|FD-Score:-4.7|P-value:1.31E-6||SGD DESC:Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock Gene:PDC6(YGR087C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation Gene:PDR1(YGL013C)|FD-Score:4.27|P-value:9.81E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PRM9(YAR031W)|FD-Score:5.12|P-value:1.54E-7||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RAD26(YJR035W)|FD-Score:3.3|P-value:4.80E-4||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RAD27(YKL113C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family Gene:RPE1(YJL121C)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress Gene:RPL21A(YBR191W)|FD-Score:-3.22|P-value:6.45E-4||SGD DESC:Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:RPS27A(YKL156W)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RRG8(YPR116W)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport Gene:RTC6(YPL183W-A)|FD-Score:3.81|P-value:7.06E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SEA4(YBL104C)|FD-Score:4.56|P-value:2.59E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEF1(YBL066C)|FD-Score:-4.3|P-value:8.55E-6||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SIN4(YNL236W)|FD-Score:7.27|P-value:1.76E-13||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SLM4(YBR077C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SPE4(YLR146C)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid Gene:SPG5(YMR191W)|FD-Score:-3.09|P-value:9.97E-4||SGD DESC:Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SWP82(YFL049W)|FD-Score:8.69|P-value:1.84E-18||SGD DESC:Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions Gene:SYS1(YJL004C)|FD-Score:5.77|P-value:3.92E-9||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:THI7(YLR237W)|FD-Score:-4.08|P-value:2.21E-5||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TIF4632(YGL049C)|FD-Score:-3.26|P-value:5.51E-4||SGD DESC:Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:4.34|P-value:7.17E-6||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP4(YDR354W)|FD-Score:5.52|P-value:1.70E-8||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TSL1(YML100W)|FD-Score:-3.74|P-value:9.31E-5||SGD DESC:Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication Gene:URK1(YNR012W)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP Gene:YBL095W(YBL095W_p)|FD-Score:-4.18|P-value:1.46E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR225W(YBR225W_p)|FD-Score:3.73|P-value:9.69E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YBR292C(YBR292C_d)|FD-Score:4.62|P-value:1.96E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YCR007C(YCR007C_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene Gene:YDR114C(YDR114C_p)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YGL159W(YGL159W_p)|FD-Score:4.57|P-value:2.40E-6||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGL217C(YGL217C_d)|FD-Score:-3.84|P-value:6.10E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Gene:YGR051C(YGR051C_d)|FD-Score:3.14|P-value:8.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Gene:YGR067C(YGR067C_p)|FD-Score:-4.32|P-value:7.75E-6||SGD DESC:Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Gene:YHL015W-A(YHL015W-A_p)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Putative protein of unknown function Gene:YHR033W(YHR033W_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication Gene:YHR139C-A(YHR139C-A_d)|FD-Score:-4.57|P-value:2.41E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIR020C(YIR020C_p)|FD-Score:-4.33|P-value:7.62E-6||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YIR020W-A(YIR020W-A_d)|FD-Score:4.81|P-value:7.54E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YJR079W(YJR079W_p)|FD-Score:4.33|P-value:7.39E-6||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YKL077W(YKL077W_p)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YLR255C(YLR255C_d)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR144W(YMR144W_p)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene Gene:YNL034W(YNL034W_p)|FD-Score:-3.09|P-value:9.97E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YNR021W(YNR021W_p)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene Gene:YOR199W(YOR199W_d)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPK1(YKL126W)|FD-Score:4.48|P-value:3.82E-6||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR039W(YPR039W_d)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YRM1(YOR172W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:ADE1(YAR015W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress Gene:AGX1(YFL030W)|FD-Score:4.96|P-value:3.57E-7||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:AHC2(YCR082W)|FD-Score:3.34|P-value:4.17E-4||SGD DESC:Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex Gene:AIM24(YJR080C)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss Gene:ARN2(YHL047C)|FD-Score:-3.34|P-value:4.16E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:BFA1(YJR053W)|FD-Score:-3.98|P-value:3.51E-5||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:BFR1(YOR198C)|FD-Score:3.47|P-value:2.55E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:BOI2(YER114C)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:CHL1(YPL008W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome Gene:CNA1(YLR433C)|FD-Score:-3.9|P-value:4.71E-5||SGD DESC:Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 Gene:CUL3(YGR003W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 Gene:DGR1(YNL130C-A_p)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose Gene:EAF3(YPR023C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:EAP1(YKL204W)|FD-Score:-4.52|P-value:3.12E-6||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:EAR1(YMR171C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p Gene:EMC1(YCL045C)|FD-Score:4.43|P-value:4.73E-6||SGD DESC:Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 Gene:EMC5(YIL027C)|FD-Score:-3.4|P-value:3.36E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT Gene:ERG4(YGL012W)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol Gene:ERG5(YMR015C)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERP1(YAR002C-A)|FD-Score:4.26|P-value:1.00E-5||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:ERV25(YML012W)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport Gene:EST3(YIL009C-A)|FD-Score:-3.4|P-value:3.35E-4||SGD DESC:Component of the telomerase holoenzyme, involved in telomere replication Gene:FES1(YBR101C)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FIG4(YNL325C)|FD-Score:-3.16|P-value:7.87E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:FLC2(YAL053W)|FD-Score:4.47|P-value:3.97E-6||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FMO1(YHR176W)|FD-Score:-4.66|P-value:1.58E-6||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FOX2(YKR009C)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:FUR4(YBR021W)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:GCN20(YFR009W)|FD-Score:3.81|P-value:6.93E-5||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GTO1(YGR154C)|FD-Score:4.75|P-value:1.03E-6||SGD DESC:Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization Gene:GYL1(YMR192W)|FD-Score:3.92|P-value:4.38E-5||SGD DESC:Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:HIR1(YBL008W)|FD-Score:3.3|P-value:4.75E-4||SGD DESC:Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores Gene:HRK1(YOR267C)|FD-Score:-3.15|P-value:8.19E-4||SGD DESC:Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress Gene:HSL7(YBR133C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:IMG2(YCR071C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IRC4(YDR540C)|FD-Score:3.89|P-value:4.94E-5||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:IRC7(YFR055W_p)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner Gene:JEM1(YJL073W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 Gene:MFA1(YDR461W)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 Gene:MIG3(YER028C)|FD-Score:3.86|P-value:5.78E-5||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRPL16(YBL038W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL23(YOR150W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPL4(YBR170C)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) Gene:NRG2(YBR066C)|FD-Score:-3.33|P-value:4.31E-4||SGD DESC:Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication Gene:OM45(YIL136W)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress Gene:OPI3(YJR073C)|FD-Score:-4.33|P-value:7.31E-6||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PAU13(YHL046C)|FD-Score:-4.7|P-value:1.31E-6||SGD DESC:Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock Gene:PDC6(YGR087C)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation Gene:PDR1(YGL013C)|FD-Score:4.27|P-value:9.81E-6||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PRM9(YAR031W)|FD-Score:5.12|P-value:1.54E-7||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RAD26(YJR035W)|FD-Score:3.3|P-value:4.80E-4||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RAD27(YKL113C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family Gene:RPE1(YJL121C)|FD-Score:4.66|P-value:1.58E-6||SGD DESC:D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress Gene:RPL21A(YBR191W)|FD-Score:-3.22|P-value:6.45E-4||SGD DESC:Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication Gene:RPN13(YLR421C)|FD-Score:-3.18|P-value:7.42E-4||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress Gene:RPS27A(YKL156W)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RRG8(YPR116W)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport Gene:RTC6(YPL183W-A)|FD-Score:3.81|P-value:7.06E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SEA4(YBL104C)|FD-Score:4.56|P-value:2.59E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEF1(YBL066C)|FD-Score:-4.3|P-value:8.55E-6||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SIN4(YNL236W)|FD-Score:7.27|P-value:1.76E-13||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SLM4(YBR077C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 Gene:SPE4(YLR146C)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid Gene:SPG5(YMR191W)|FD-Score:-3.09|P-value:9.97E-4||SGD DESC:Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SWP82(YFL049W)|FD-Score:8.69|P-value:1.84E-18||SGD DESC:Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions Gene:SYS1(YJL004C)|FD-Score:5.77|P-value:3.92E-9||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:THI7(YLR237W)|FD-Score:-4.08|P-value:2.21E-5||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TIF4632(YGL049C)|FD-Score:-3.26|P-value:5.51E-4||SGD DESC:Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:4.34|P-value:7.17E-6||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP2(YER090W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP4(YDR354W)|FD-Score:5.52|P-value:1.70E-8||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TSL1(YML100W)|FD-Score:-3.74|P-value:9.31E-5||SGD DESC:Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication Gene:URK1(YNR012W)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP Gene:YBL095W(YBL095W_p)|FD-Score:-4.18|P-value:1.46E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR225W(YBR225W_p)|FD-Score:3.73|P-value:9.69E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components Gene:YBR292C(YBR292C_d)|FD-Score:4.62|P-value:1.96E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YCR007C(YCR007C_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene Gene:YDR114C(YDR114C_p)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YGL159W(YGL159W_p)|FD-Score:4.57|P-value:2.40E-6||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGL217C(YGL217C_d)|FD-Score:-3.84|P-value:6.10E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Gene:YGR051C(YGR051C_d)|FD-Score:3.14|P-value:8.34E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Gene:YGR067C(YGR067C_p)|FD-Score:-4.32|P-value:7.75E-6||SGD DESC:Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Gene:YHL015W-A(YHL015W-A_p)|FD-Score:4.21|P-value:1.26E-5||SGD DESC:Putative protein of unknown function Gene:YHR033W(YHR033W_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication Gene:YHR139C-A(YHR139C-A_d)|FD-Score:-4.57|P-value:2.41E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.2|P-value:6.85E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIR020C(YIR020C_p)|FD-Score:-4.33|P-value:7.62E-6||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YIR020W-A(YIR020W-A_d)|FD-Score:4.81|P-value:7.54E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YJR079W(YJR079W_p)|FD-Score:4.33|P-value:7.39E-6||SGD DESC:Putative protein of unknown function; mutation results in impaired mitochondrial respiration Gene:YKL077W(YKL077W_p)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YLR255C(YLR255C_d)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR144W(YMR144W_p)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene Gene:YNL034W(YNL034W_p)|FD-Score:-3.09|P-value:9.97E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YNR021W(YNR021W_p)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene Gene:YOR199W(YOR199W_d)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPK1(YKL126W)|FD-Score:4.48|P-value:3.82E-6||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR039W(YPR039W_d)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YRM1(YOR172W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL102C_d6.389.09E-111.25YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YKL165C5.121.50E-70.86MCD4Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YOR074C4.261.00E-50.11CDC21Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YLR066W4.151.64E-50.39SPC3Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YGR094W3.768.48E-50.02VAS1Mitochondrial and cytoplasmic valyl-tRNA synthetase
YMR213W3.749.20E-50.03CEF1Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YBL105C3.711.04E-40.07PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YOL038W3.641.38E-40.03PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YOR102W_d3.611.53E-40.01YOR102W_dDubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
YLR078C3.601.60E-40.02BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YDR086C3.581.73E-40.15SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YBR202W3.433.03E-40.07MCM7Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
YGR175C3.353.97E-40.05ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YBL097W3.304.81E-40.14BRN1Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
YER148W3.167.96E-40.08SPT15TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFL049W8.691.84E-18SWP82Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
YNL236W7.271.76E-13SIN4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
YJL004C5.773.92E-9SYS1Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YDR354W5.521.70E-8TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YAR031W5.121.54E-7PRM9Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
YFL030W4.963.57E-7AGX1Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YIR020W-A_d4.817.54E-7YIR020W-A_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGR154C4.751.03E-6GTO1Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YJL121C4.661.58E-6RPE1D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YBR292C_d4.621.96E-6YBR292C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YGL159W_p4.572.40E-6YGL159W_pPutative protein of unknown function; deletion mutant has no detectable phenotype
YBL104C4.562.59E-6SEA4Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
YKL126W4.483.82E-6YPK1Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
YAL053W4.473.97E-6FLC2Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
YCL045C4.434.73E-6EMC1Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090

GO enrichment analysis for SGTC_1259
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1101.89E-17SGTC_305-(2-thienylidene)-Rhodanine 28.7 μMChemDiv (Drug-like library)12411320.0615385
0.1087.01E-17SGTC_500929-0078 56.4 μMChemDiv (Drug-like library)13777510.0634921
0.1055.71E-16SGTC_24885268135 45.7 μMMiscellaneous12703560.0615385
0.1048.90E-16SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.056338
0.1023.07E-15SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.0655738TRP & mitochondrial translation
0.1018.76E-15SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.0689655TRP & mitochondrial translation
0.1001.66E-14SGTC_10410206-0046 107.0 μMChemDiv (Drug-like library)504940.0735294
0.1001.73E-14SGTC_21375261020 140.0 μMChembridge (Fragment library)7636550.0895522
0.0984.51E-14SGTC_2524avocatin b 10.6 μMMicrosource (Natural product library)6710748NA
0.0985.50E-14SGTC_7670929-0023 86.0 μMChemDiv (Drug-like library)12045630.0724638TRP & mitochondrial translation
0.0985.60E-14SGTC_20935331342 194.4 μMChembridge (Fragment library)338390.0447761
0.0985.87E-14SGTC_505gw-5074 63.9 μMICCB bioactive library59242080.102941
0.0976.63E-14SGTC_29399044578 71.4 μMChembridge (Drug-like library)26536340.115385
0.0971.00E-13SGTC_1671st016596 74.5 μMTimTec (Natural product derivative library)28291670.0933333
0.0961.09E-13SGTC_2618avocadyne 43.4 μMMicrosource (Natural product library)3015189NA

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_14284049-020461.7 μM0.5625X1428ChemDiv (Drug-like library)324.327423.38941
SGTC_340469-068381.75 μM0.4897963690923ChemDiv (Drug-like library)337.307942.59217SWF1 & branched chain AA biosynthesis
SGTC_10024049-0206172 μM0.484662749ChemDiv (Drug-like library)310.3008432.90316
SGTC_15141189-1591158 μM0.46767698ChemDiv (Drug-like library)320.363543.6715
SGTC_14294049-02059.46 μM0.42857122774478ChemDiv (Drug-like library)344.1993433.75714
SGTC_990109-0120622.8 μM0.416667759414ChemDiv (Drug-like library)321.126163.25713
SGTC_5983937-023620.2 μM0.3888891379313ChemDiv (Drug-like library)354.80864.33515ERG2
SGTC_7150868-0130184 μM0.3833332876258ChemDiv (Drug-like library)439.441182.73627
SGTC_9491165-0505146 μM0.3653856244267ChemDiv (Drug-like library)304.321082.15415
SGTC_8080711-0032135 μM0.3636364252555ChemDiv (Drug-like library)370.218382.92115