Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL196W_d | 4.77 | 9.25E-7 | 0.54 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YGL102C_d | 4.27 | 9.85E-6 | 0.54 | YGL102C_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein |
YJL050W | 3.73 | 9.48E-5 | 0.07 | MTR4 | ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing |
YGR029W | 3.66 | 1.25E-4 | 0.01 | ERV1 | Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) |
YPL044C_d | 3.65 | 1.29E-4 | 0.02 | YPL044C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W |
YLR457C | 3.63 | 1.42E-4 | 0.06 | NBP1 | Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication |
YDR212W | 3.56 | 1.82E-4 | 0.03 | TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
YBR211C | 3.54 | 2.04E-4 | 0.07 | AME1 | Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress |
YIL078W | 3.47 | 2.64E-4 | 0.24 | THS1 | Threonyl-tRNA synthetase, essential cytoplasmic protein |
YNL256W | 3.23 | 6.24E-4 | 0.04 | FOL1 | Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities |
YBL040C | 3.18 | 7.28E-4 | 0.03 | ERD2 | HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins |
YDL060W | 3.15 | 8.13E-4 | 0.10 | TSR1 | Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YOL010W | 3.06 | 0.00112 | 0.22 | RCL1 | Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected |
YDR526C_d | 2.83 | 0.00232 | 0.01 | YDR526C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPR010C | 2.82 | 0.00240 | 0.03 | RPA135 | RNA polymerase I second largest subunit A135 |