0832-2808

5-(1-adamantyl)-2-methoxyaniline

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1271
Screen concentration 169.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 3663794
SMILES COC1=C(C=C(C=C1)C23CC4CC(C2)CC(C4)C3)N
Standardized SMILES COc1ccc(cc1N)C23CC4CC(CC(C4)C2)C3
Molecular weight 257.3706
ALogP 3.48
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 32.13
% growth inhibition (Hom. pool) 5.14


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3663794
Download HIP data (tab-delimited text)  (excel)
Gene:CAB2(YIL083C)|FD-Score:3.71|P-value:1.03E-4|Clearance:0.04||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:CCT2(YIL142W)|FD-Score:3.42|P-value:3.08E-4|Clearance:0.03||SGD DESC:Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CCT4(YDL143W)|FD-Score:3.11|P-value:9.35E-4|Clearance:0.12||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CFD1(YIL003W)|FD-Score:3.34|P-value:4.20E-4|Clearance:0.07||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:ERG9(YHR190W)|FD-Score:3.27|P-value:5.38E-4|Clearance:0.15||SGD DESC:Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway Gene:GLC7(YER133W)|FD-Score:-3.19|P-value:7.08E-4|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GPI13(YLL031C)|FD-Score:3.12|P-value:9.18E-4|Clearance:0.01||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:HEM12(YDR047W)|FD-Score:7.61|P-value:1.32E-14|Clearance:1.7||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:ORC4(YPR162C)|FD-Score:3.52|P-value:2.18E-4|Clearance:0.09||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:ORC6(YHR118C)|FD-Score:3.83|P-value:6.54E-5|Clearance:0.07||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p Gene:PDC2(YDR081C)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions Gene:PIK1(YNL267W)|FD-Score:-4.45|P-value:4.32E-6|Clearance:0||SGD DESC:Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton Gene:PRE3(YJL001W)|FD-Score:-3.88|P-value:5.12E-5|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:PSA1(YDL055C)|FD-Score:-3.47|P-value:2.60E-4|Clearance:0||SGD DESC:GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure Gene:QNS1(YHR074W)|FD-Score:8.05|P-value:4.01E-16|Clearance:1.7||SGD DESC:Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide Gene:RBA50(YDR527W)|FD-Score:3.39|P-value:3.44E-4|Clearance:0.04||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RPL25(YOL127W)|FD-Score:3.75|P-value:8.83E-5|Clearance:0.04||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:RPL32(YBL092W)|FD-Score:4.22|P-value:1.20E-5|Clearance:0.4||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:SMC5(YOL034W)|FD-Score:3.76|P-value:8.56E-5|Clearance:0.01||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SPN1(YPR133C)|FD-Score:6.35|P-value:1.06E-10|Clearance:1.7||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:TIM12(YBR091C)|FD-Score:3.67|P-value:1.22E-4|Clearance:0.15||SGD DESC:Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins Gene:YOR282W(YOR282W_d)|FD-Score:3.35|P-value:4.03E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C Gene:YTH1(YPR107C)|FD-Score:4.65|P-value:1.63E-6|Clearance:0.43||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:CAB2(YIL083C)|FD-Score:3.71|P-value:1.03E-4|Clearance:0.04||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:CCT2(YIL142W)|FD-Score:3.42|P-value:3.08E-4|Clearance:0.03||SGD DESC:Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CCT4(YDL143W)|FD-Score:3.11|P-value:9.35E-4|Clearance:0.12||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CFD1(YIL003W)|FD-Score:3.34|P-value:4.20E-4|Clearance:0.07||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:ERG9(YHR190W)|FD-Score:3.27|P-value:5.38E-4|Clearance:0.15||SGD DESC:Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway Gene:GLC7(YER133W)|FD-Score:-3.19|P-value:7.08E-4|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GPI13(YLL031C)|FD-Score:3.12|P-value:9.18E-4|Clearance:0.01||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:HEM12(YDR047W)|FD-Score:7.61|P-value:1.32E-14|Clearance:1.7||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:ORC4(YPR162C)|FD-Score:3.52|P-value:2.18E-4|Clearance:0.09||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:ORC6(YHR118C)|FD-Score:3.83|P-value:6.54E-5|Clearance:0.07||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p Gene:PDC2(YDR081C)|FD-Score:-3.19|P-value:7.02E-4|Clearance:0||SGD DESC:Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions Gene:PIK1(YNL267W)|FD-Score:-4.45|P-value:4.32E-6|Clearance:0||SGD DESC:Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton Gene:PRE3(YJL001W)|FD-Score:-3.88|P-value:5.12E-5|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:PSA1(YDL055C)|FD-Score:-3.47|P-value:2.60E-4|Clearance:0||SGD DESC:GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure Gene:QNS1(YHR074W)|FD-Score:8.05|P-value:4.01E-16|Clearance:1.7||SGD DESC:Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide Gene:RBA50(YDR527W)|FD-Score:3.39|P-value:3.44E-4|Clearance:0.04||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RPL25(YOL127W)|FD-Score:3.75|P-value:8.83E-5|Clearance:0.04||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:RPL32(YBL092W)|FD-Score:4.22|P-value:1.20E-5|Clearance:0.4||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:SMC5(YOL034W)|FD-Score:3.76|P-value:8.56E-5|Clearance:0.01||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SPN1(YPR133C)|FD-Score:6.35|P-value:1.06E-10|Clearance:1.7||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:TIM12(YBR091C)|FD-Score:3.67|P-value:1.22E-4|Clearance:0.15||SGD DESC:Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins Gene:YOR282W(YOR282W_d)|FD-Score:3.35|P-value:4.03E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C Gene:YTH1(YPR107C)|FD-Score:4.65|P-value:1.63E-6|Clearance:0.43||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3663794
Download HOP data (tab-delimited text)  (excel)
Gene:AHA1(YDR214W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM37(YNL100W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture Gene:ATG15(YCR068W)|FD-Score:4.18|P-value:1.47E-5||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:CAF130(YGR134W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CHK1(YBR274W)|FD-Score:-3.12|P-value:9.02E-4||SGD DESC:Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase Gene:COG5(YNL051W)|FD-Score:3.73|P-value:9.48E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR2(YHR057C)|FD-Score:3.77|P-value:8.30E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DIA3(YDL024C)|FD-Score:-4.19|P-value:1.42E-5||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DOT6(YER088C)|FD-Score:4.35|P-value:6.94E-6||SGD DESC:Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:DSK2(YMR276W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress Gene:ELG1(YOR144C)|FD-Score:3.94|P-value:4.08E-5||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:ERG28(YER044C)|FD-Score:-5.01|P-value:2.79E-7||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:FIT1(YDR534C)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:MDM12(YOL009C)|FD-Score:5.75|P-value:4.38E-9||SGD DESC:Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins Gene:MET13(YGL125W)|FD-Score:-6.07|P-value:6.48E-10||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MET3(YJR010W)|FD-Score:4.04|P-value:2.71E-5||SGD DESC:ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism Gene:MIP6(YHR015W)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:MSS18(YPR134W)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:NTG2(YOL043C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OM14(YBR230C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:OSH7(YHR001W)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability Gene:PDR17(YNL264C)|FD-Score:3.8|P-value:7.18E-5||SGD DESC:Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Gene:PEX5(YDR244W)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions Gene:PLP1(YDR183W)|FD-Score:3.31|P-value:4.62E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:RPA14(YDR156W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:RNA polymerase I subunit A14 Gene:RPL34A(YER056C-A)|FD-Score:4.99|P-value:2.95E-7||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPL7A(YGL076C)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:3.17|P-value:7.49E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAM3(YPL274W)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SHO1(YER118C)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p Gene:SIP4(YJL089W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SMM1(YNR015W)|FD-Score:3.09|P-value:9.89E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:SNF6(YHL025W)|FD-Score:-6.26|P-value:1.97E-10||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SPT10(YJL127C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SUR1(YPL057C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TRM2(YKR056W)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:TRP1(YDR007W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TVP15(YDR100W)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:UBI4(YLL039C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UBX6(YJL048C)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication Gene:VPS52(YDR484W)|FD-Score:-4.36|P-value:6.48E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:VPS72(YDR485C)|FD-Score:4.39|P-value:5.69E-6||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YAT2(YER024W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBT1(YLL048C)|FD-Score:4.35|P-value:6.66E-6||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YCR099C(YCR099C_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function Gene:YDR133C(YDR133C_d)|FD-Score:4.75|P-value:1.03E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Putative protein of unknown function Gene:YGR042W(YGR042W_p)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YIL014C-A(YIL014C-A_p)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Putative protein of unknown function Gene:YJL218W(YJL218W_p)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene Gene:YML054C-A(YML054C-A_p)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function Gene:YPL152W-A(YPL152W-A_p)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:AHA1(YDR214W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM37(YNL100W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture Gene:ATG15(YCR068W)|FD-Score:4.18|P-value:1.47E-5||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:CAF130(YGR134W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CHK1(YBR274W)|FD-Score:-3.12|P-value:9.02E-4||SGD DESC:Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase Gene:COG5(YNL051W)|FD-Score:3.73|P-value:9.48E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR2(YHR057C)|FD-Score:3.77|P-value:8.30E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DIA3(YDL024C)|FD-Score:-4.19|P-value:1.42E-5||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DOT6(YER088C)|FD-Score:4.35|P-value:6.94E-6||SGD DESC:Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:DSK2(YMR276W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress Gene:ELG1(YOR144C)|FD-Score:3.94|P-value:4.08E-5||SGD DESC:Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication Gene:ERG28(YER044C)|FD-Score:-5.01|P-value:2.79E-7||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:FIT1(YDR534C)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:MDM12(YOL009C)|FD-Score:5.75|P-value:4.38E-9||SGD DESC:Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins Gene:MET13(YGL125W)|FD-Score:-6.07|P-value:6.48E-10||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MET3(YJR010W)|FD-Score:4.04|P-value:2.71E-5||SGD DESC:ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism Gene:MIP6(YHR015W)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:MSS18(YPR134W)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:NTG2(YOL043C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OM14(YBR230C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:OSH7(YHR001W)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability Gene:PDR17(YNL264C)|FD-Score:3.8|P-value:7.18E-5||SGD DESC:Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Gene:PEX5(YDR244W)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions Gene:PLP1(YDR183W)|FD-Score:3.31|P-value:4.62E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:RPA14(YDR156W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:RNA polymerase I subunit A14 Gene:RPL34A(YER056C-A)|FD-Score:4.99|P-value:2.95E-7||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPL7A(YGL076C)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:3.17|P-value:7.49E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAM3(YPL274W)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SHO1(YER118C)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p Gene:SIP4(YJL089W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SMM1(YNR015W)|FD-Score:3.09|P-value:9.89E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:SNF6(YHL025W)|FD-Score:-6.26|P-value:1.97E-10||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions Gene:SPT10(YJL127C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SUR1(YPL057C)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TRM2(YKR056W)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:TRP1(YDR007W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TVP15(YDR100W)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:UBI4(YLL039C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:UBX6(YJL048C)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication Gene:VPS52(YDR484W)|FD-Score:-4.36|P-value:6.48E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:VPS72(YDR485C)|FD-Score:4.39|P-value:5.69E-6||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YAT2(YER024W)|FD-Score:-3.63|P-value:1.40E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBT1(YLL048C)|FD-Score:4.35|P-value:6.66E-6||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YCR099C(YCR099C_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function Gene:YDR133C(YDR133C_d)|FD-Score:4.75|P-value:1.03E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Putative protein of unknown function Gene:YGR042W(YGR042W_p)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YIL014C-A(YIL014C-A_p)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Putative protein of unknown function Gene:YJL218W(YJL218W_p)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene Gene:YML054C-A(YML054C-A_p)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function Gene:YPL152W-A(YPL152W-A_p)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR074W8.054.01E-161.70QNS1Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YDR047W7.611.32E-141.70HEM12Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YPR133C6.351.06E-101.70SPN1Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
YPR107C4.651.63E-60.43YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YBL092W4.221.20E-50.40RPL32Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
YHR118C3.836.54E-50.07ORC6Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YOL034W3.768.56E-50.01SMC5Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YOL127W3.758.83E-50.04RPL25Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
YIL083C3.711.03E-40.04CAB2Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
YBR091C3.671.22E-40.15TIM12Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YPR162C3.522.18E-40.09ORC4Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YIL142W3.423.08E-40.03CCT2Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR527W3.393.44E-40.04RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YOR282W_d3.354.03E-40.01YOR282W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
YIL003W3.344.20E-40.07CFD1Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL009C5.754.38E-9MDM12Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins
YER056C-A4.992.95E-7RPL34ARibosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
YDR133C_d4.751.03E-6YDR133C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR485C4.395.69E-6VPS72Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YLL048C4.356.66E-6YBT1Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
YER088C4.356.94E-6DOT6Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YCR068W4.181.47E-5ATG15Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YJL048C4.151.66E-5UBX6UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication
YJR010W4.042.71E-5MET3ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YER118C4.013.04E-5SHO1Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
YDR534C3.963.77E-5FIT1Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR144C3.944.08E-5ELG1Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
YHR001W3.885.17E-5OSH7Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YNL264C3.807.18E-5PDR17Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
YHR057C3.778.30E-5CPR2Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway

GO enrichment analysis for SGTC_1271
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1397.25E-27SGTC_273hydroxyurea 18.1 mMMiscellaneous36570.0243902heme biosynthesis & mitochondrial translocase
0.1293.74E-23SGTC_10258-0098 57.4 μMChemDiv (Drug-like library)67900320.121212heme biosynthesis & mitochondrial translocase
0.1164.24E-19SGTC_3324112-0506 40.9 μMChemDiv (Drug-like library)27903550.0793651
0.0872.74E-11SGTC_1040074-0074 591.0 μMChemDiv (Drug-like library)39431240.0952381
0.0841.07E-10SGTC_30641327-0027 10.0 μMChemDiv (Drug-like library)160004550.0571429
0.0831.44E-10SGTC_13742889-5571 141.0 μMChemDiv (Drug-like library)28532810.0923077RSC complex & mRNA processing
0.0791.24E-9SGTC_305-(2-thienylidene)-Rhodanine 28.7 μMChemDiv (Drug-like library)12411320.05
0.0782.14E-9SGTC_260302-0163 425.2 μMChemDiv (Drug-like library)31009150.0666667heme biosynthesis & mitochondrial translocase
0.0772.58E-9SGTC_12660828-0227 32.9 μMChemDiv (Drug-like library)39138200.0508475
0.0773.66E-9SGTC_11564092-0367 4.9 μMChemDiv (Drug-like library)13575850.0895522
0.0764.12E-9SGTC_11921488-0095 21.4 μMChemDiv (Drug-like library)9158750.0625
0.0759.80E-9SGTC_13903413-2614 145.0 μMChemDiv (Drug-like library)34214320.0535714fatty acid desaturase (OLE1)
0.0741.25E-8SGTC_8420271-0008 11.1 μMChemDiv (Drug-like library)12217090.0545455heme biosynthesis & mitochondrial translocase
0.0732.44E-8SGTC_208k072-0098 12.4 μMChemDiv (Drug-like library)59489010.0677966heme biosynthesis & mitochondrial translocase
0.0714.29E-8SGTC_11861319-0216 26.0 μMChemDiv (Drug-like library)45651360.103896

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_450kpi-003614.9 μM0.4752795021ChemDiv (Drug-like library)242.355984.48311excess fatty acid
SGTC_794k038-0031316 μM0.4693886624242ChemDiv (Drug-like library)405.529245.78604ubiquinone biosynthesis & proteasome
SGTC_670335-0847266 μM0.464552207ChemDiv (Drug-like library)375.503265.80303ubiquinone biosynthesis & proteasome
SGTC_5850kpi-0023191 μM0.464601ChemDiv (Drug-like library)272.33893.62723
SGTC_1080509-0257621.13 μM0.386364536624ChemDiv (Drug-like library)269.381323.3611
SGTC_9541189-08532.85 μM0.3404262828194ChemDiv (Drug-like library)255.39783.55111endomembrane recycling
SGTC_635k038-002824.7 μM0.3275864035102ChemDiv (Drug-like library)381.9134037.19202ubiquinone biosynthesis & proteasome
SGTC_294k038-0071157 μM0.32692324152826ChemDiv (Drug-like library)335.50566.27502ubiquinone biosynthesis & proteasome
SGTC_216k038-003528.38 μM0.3265314444231ChemDiv (Drug-like library)316.439364.68502ubiquinone biosynthesis & proteasome
SGTC_340k038-0059454 μM0.32075523733424ChemDiv (Drug-like library)400.375086.53702ubiquinone biosynthesis & proteasome