| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YLR091W | 7.07 | 7.83E-13 | GEP5 | Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine |
| YDR405W | 6.82 | 4.40E-12 | MRP20 | Mitochondrial ribosomal protein of the large subunit |
| YDL151C_d | 6.30 | 1.51E-10 | BUD30_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
| YLR262C | 5.67 | 6.99E-9 | YPT6 | Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 |
| YDR136C_d | 5.30 | 5.88E-8 | VPS61_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect |
| YIL140W | 5.19 | 1.03E-7 | AXL2 | Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate |
| YPL086C | 5.15 | 1.28E-7 | ELP3 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin |
| YOR200W_d | 5.06 | 2.11E-7 | YOR200W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c |
| YJR144W | 4.56 | 2.54E-6 | MGM101 | Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage |
| YBL080C | 4.56 | 2.55E-6 | PET112 | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog |
| YGR219W_d | 4.56 | 2.62E-6 | YGR219W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C |
| YIL047C | 4.51 | 3.21E-6 | SYG1 | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency |
| YOR018W | 4.49 | 3.51E-6 | ROD1 | Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication |
| YDL192W | 4.45 | 4.30E-6 | ARF1 | ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication |
| YGR014W | 4.44 | 4.60E-6 | MSB2 | Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate |
