Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR073C_d | 5.62 | 9.80E-9 | 1.44 | YGR073C_d | Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein |
YIL104C | 4.18 | 1.47E-5 | 0.20 | SHQ1 | Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones |
YJR023C_d | 3.97 | 3.54E-5 | 0.04 | YJR023C_d | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing |
YIL142W | 3.93 | 4.23E-5 | 0.31 | CCT2 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YKL182W | 3.62 | 1.48E-4 | 0.36 | FAS1 | Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities |
YPL075W | 3.25 | 5.69E-4 | 0.18 | GCR1 | Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p |
YJR112W | 3.07 | 0.00105 | 0.09 | NNF1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation |
YGR218W | 2.99 | 0.00141 | 0.07 | CRM1 | Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin |
YOR250C | 2.92 | 0.00178 | 0.18 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YDL196W_d | 2.74 | 0.00308 | 0.06 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YHR197W | 2.68 | 0.00371 | 0.08 | RIX1 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene |
YGL120C | 2.60 | 0.00465 | 0.00 | PRP43 | RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome |
YJL061W | 2.60 | 0.00467 | 0.02 | NUP82 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p) |
YJL173C | 2.58 | 0.00501 | 0.10 | RFA3 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
YIL004C | 2.48 | 0.00657 | 0.04 | BET1 | Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins |