Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR084C | 7.25 | 2.04E-13 | RAX2 | N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p |
YIL032C_d | 5.65 | 7.87E-9 | YIL032C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YMR021C | 4.89 | 5.02E-7 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
YPR171W | 4.73 | 1.10E-6 | BSP1 | Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton |
YDR424C | 4.71 | 1.22E-6 | DYN2 | Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex |
YPL267W | 4.71 | 1.25E-6 | ACM1 | Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein |
YDR329C | 4.57 | 2.47E-6 | PEX3 | Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p |
YMR086W | 4.52 | 3.08E-6 | SEG1 | Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes |
YAL020C | 4.36 | 6.39E-6 | ATS1 | Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle |
YGR070W | 4.26 | 1.04E-5 | ROM1 | GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP |
YLR036C_p | 4.25 | 1.07E-5 | YLR036C_p | Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein |
YGL071W | 4.06 | 2.44E-5 | AFT1 | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YMR026C | 4.05 | 2.51E-5 | PEX12 | C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder |
YBR007C_p | 4.04 | 2.65E-5 | DSF2_p | Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YBR001C | 4.04 | 2.67E-5 | NTH2 | Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication |