0976-0073

N-[2-(4-methylphenyl)-2-oxoethyl]benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1289
Screen concentration 69.1 μM
Source ChemDiv (Drug-like library)
PubChem CID 3391136
SMILES CC1=CC=C(C=C1)C(=O)CNC(=O)C2=CC=CC=C2
Standardized SMILES Cc1ccc(cc1)C(=O)CNC(=O)c2ccccc2
Molecular weight 253.2958
ALogP 2.78
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.77
% growth inhibition (Hom. pool) 5.97


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3391136
Download HIP data (tab-delimited text)  (excel)
Gene:CCT3(YJL014W)|FD-Score:4.89|P-value:5.15E-7|Clearance:0.65||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:GPI18(YBR004C)|FD-Score:3.2|P-value:6.90E-4|Clearance:0.04||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:HEM3(YDL205C)|FD-Score:-3.87|P-value:5.34E-5|Clearance:0||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:ILV5(YLR355C)|FD-Score:3.16|P-value:8.02E-4|Clearance:0.03||SGD DESC:Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids Gene:MCD1(YDL003W)|FD-Score:4.09|P-value:2.14E-5|Clearance:0.65||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:PRP45(YAL032C)|FD-Score:3.13|P-value:8.82E-4|Clearance:0.05||SGD DESC:Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene Gene:RPL32(YBL092W)|FD-Score:-3.82|P-value:6.70E-5|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:SEC4(YFL005W)|FD-Score:4.03|P-value:2.80E-5|Clearance:0.65||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:UBC1(YDR177W)|FD-Score:3.38|P-value:3.62E-4|Clearance:0.18||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:UTP22(YGR090W)|FD-Score:4.37|P-value:6.17E-6|Clearance:0.65||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:CCT3(YJL014W)|FD-Score:4.89|P-value:5.15E-7|Clearance:0.65||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:GPI18(YBR004C)|FD-Score:3.2|P-value:6.90E-4|Clearance:0.04||SGD DESC:Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria Gene:HEM3(YDL205C)|FD-Score:-3.87|P-value:5.34E-5|Clearance:0||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:ILV5(YLR355C)|FD-Score:3.16|P-value:8.02E-4|Clearance:0.03||SGD DESC:Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids Gene:MCD1(YDL003W)|FD-Score:4.09|P-value:2.14E-5|Clearance:0.65||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:PRP45(YAL032C)|FD-Score:3.13|P-value:8.82E-4|Clearance:0.05||SGD DESC:Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene Gene:RPL32(YBL092W)|FD-Score:-3.82|P-value:6.70E-5|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:SEC4(YFL005W)|FD-Score:4.03|P-value:2.80E-5|Clearance:0.65||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:UBC1(YDR177W)|FD-Score:3.38|P-value:3.62E-4|Clearance:0.18||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:UTP22(YGR090W)|FD-Score:4.37|P-value:6.17E-6|Clearance:0.65||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3391136
Download HOP data (tab-delimited text)  (excel)
Gene:AAC1(YMR056C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:AEP1(YMR064W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase Gene:ARG7(YMR062C)|FD-Score:-3.35|P-value:3.97E-4||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:BFR1(YOR198C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:COQ5(YML110C)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:DDR2(YOL052C-A)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication Gene:DIE2(YGR227W)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 Gene:ECM14(YHR132C)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly Gene:EGT2(YNL327W)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner Gene:ERG28(YER044C)|FD-Score:-4.32|P-value:7.81E-6||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:EST2(YLR318W)|FD-Score:5.41|P-value:3.19E-8||SGD DESC:Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia Gene:FKS3(YMR306W)|FD-Score:3.88|P-value:5.22E-5||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FTR1(YER145C)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress Gene:HAL9(YOL089C)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication Gene:HMT1(YBR034C)|FD-Score:-3.29|P-value:5.02E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IRC3(YDR332W)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:LNP1(YHR192W_p)|FD-Score:-3.19|P-value:7.18E-4||SGD DESC:Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS Gene:MEF1(YLR069C)|FD-Score:3.11|P-value:9.43E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MHF2(YDL160C-A)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRP21(YBL090W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MRPL51(YPR100W)|FD-Score:5.21|P-value:9.20E-8||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL8(YJL063C)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS35(YGR165W)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MRPS5(YBR251W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:3.86|P-value:5.63E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSR1(YHR091C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTG1(YMR097C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:PAL1(YDR348C)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:PBP2(YBR233W)|FD-Score:5.05|P-value:2.23E-7||SGD DESC:RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress Gene:PET54(YGR222W)|FD-Score:4.34|P-value:7.01E-6||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PHR1(YOR386W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p Gene:PSR1(YLL010C)|FD-Score:3.25|P-value:5.80E-4||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PTC1(YDL006W)|FD-Score:4.28|P-value:9.32E-6||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RPL19A(YBR084C-A)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication Gene:RPL22B(YFL034C-A)|FD-Score:3.75|P-value:8.94E-5||SGD DESC:Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication Gene:RPL24B(YGR148C)|FD-Score:-3.23|P-value:6.26E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPL37A(YLR185W)|FD-Score:3.72|P-value:9.93E-5||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RPL43B(YJR094W-A)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPS1A(YLR441C)|FD-Score:3.31|P-value:4.63E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RSM24(YDR175C)|FD-Score:5.85|P-value:2.50E-9||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SGM1(YJR134C)|FD-Score:3.82|P-value:6.66E-5||SGD DESC:Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus Gene:UIP3(YAR027W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:YCL074W(YCL074W)|FD-Score:4.25|P-value:1.06E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YGL149W(YGL149W_d)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Gene:YGR011W(YGR011W_d)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR042W(YGR042W_p)|FD-Score:4.61|P-value:1.99E-6||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YLR072W(YLR072W_p)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene Gene:YLR415C(YLR415C_p)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Putative protein of unknown function; YLR415C is not an essential gene Gene:YMR31(YFR049W)|FD-Score:3.09|P-value:9.96E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YMR316C-A(YMR316C-A_p)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W Gene:YOL019W-A(YOL019W-A_p)|FD-Score:4.19|P-value:1.42E-5||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YOL099C(YOL099C_d)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes Gene:YOR111W(YOR111W_p)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:Putative protein of unknown function Gene:YPR071W(YPR071W_p)|FD-Score:3.97|P-value:3.62E-5||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:AAC1(YMR056C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:AEP1(YMR064W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase Gene:ARG7(YMR062C)|FD-Score:-3.35|P-value:3.97E-4||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:BFR1(YOR198C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:COQ5(YML110C)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:DDR2(YOL052C-A)|FD-Score:3.49|P-value:2.46E-4||SGD DESC:Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication Gene:DIE2(YGR227W)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 Gene:ECM14(YHR132C)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly Gene:EGT2(YNL327W)|FD-Score:3.28|P-value:5.28E-4||SGD DESC:Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner Gene:ERG28(YER044C)|FD-Score:-4.32|P-value:7.81E-6||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:EST2(YLR318W)|FD-Score:5.41|P-value:3.19E-8||SGD DESC:Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia Gene:FKS3(YMR306W)|FD-Score:3.88|P-value:5.22E-5||SGD DESC:Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FTR1(YER145C)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress Gene:HAL9(YOL089C)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication Gene:HMT1(YBR034C)|FD-Score:-3.29|P-value:5.02E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IRC3(YDR332W)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:LNP1(YHR192W_p)|FD-Score:-3.19|P-value:7.18E-4||SGD DESC:Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS Gene:MEF1(YLR069C)|FD-Score:3.11|P-value:9.43E-4||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MHF2(YDL160C-A)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRP21(YBL090W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MRPL51(YPR100W)|FD-Score:5.21|P-value:9.20E-8||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL8(YJL063C)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS35(YGR165W)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MRPS5(YBR251W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:3.86|P-value:5.63E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSR1(YHR091C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MTG1(YMR097C)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:PAL1(YDR348C)|FD-Score:-3.44|P-value:2.90E-4||SGD DESC:Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:PBP2(YBR233W)|FD-Score:5.05|P-value:2.23E-7||SGD DESC:RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress Gene:PET54(YGR222W)|FD-Score:4.34|P-value:7.01E-6||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PHR1(YOR386W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p Gene:PSR1(YLL010C)|FD-Score:3.25|P-value:5.80E-4||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PTC1(YDL006W)|FD-Score:4.28|P-value:9.32E-6||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RPL19A(YBR084C-A)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication Gene:RPL22B(YFL034C-A)|FD-Score:3.75|P-value:8.94E-5||SGD DESC:Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication Gene:RPL24B(YGR148C)|FD-Score:-3.23|P-value:6.26E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPL37A(YLR185W)|FD-Score:3.72|P-value:9.93E-5||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:RPL43B(YJR094W-A)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPS1A(YLR441C)|FD-Score:3.31|P-value:4.63E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RSM24(YDR175C)|FD-Score:5.85|P-value:2.50E-9||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SGM1(YJR134C)|FD-Score:3.82|P-value:6.66E-5||SGD DESC:Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus Gene:UIP3(YAR027W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:YCL074W(YCL074W)|FD-Score:4.25|P-value:1.06E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YGL149W(YGL149W_d)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Gene:YGR011W(YGR011W_d)|FD-Score:3.12|P-value:9.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR042W(YGR042W_p)|FD-Score:4.61|P-value:1.99E-6||SGD DESC:Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress Gene:YLR072W(YLR072W_p)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene Gene:YLR415C(YLR415C_p)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Putative protein of unknown function; YLR415C is not an essential gene Gene:YMR31(YFR049W)|FD-Score:3.09|P-value:9.96E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YMR316C-A(YMR316C-A_p)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W Gene:YOL019W-A(YOL019W-A_p)|FD-Score:4.19|P-value:1.42E-5||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YOL099C(YOL099C_d)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes Gene:YOR111W(YOR111W_p)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:Putative protein of unknown function Gene:YPR071W(YPR071W_p)|FD-Score:3.97|P-value:3.62E-5||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL014W4.895.15E-70.65CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YGR090W4.376.17E-60.65UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YDL003W4.092.14E-50.65MCD1Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YFL005W4.032.80E-50.65SEC4Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YDR177W3.383.62E-40.18UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YBR004C3.206.90E-40.04GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YLR355C3.168.02E-40.03ILV5Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
YAL032C3.138.82E-40.05PRP45Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
YDR166C3.080.001050.02SEC5Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
YGR095C3.050.001140.02RRP46Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
YDR168W3.030.001220.09CDC37Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
YKL152C2.950.001610.03GPM1Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YOR149C2.910.001780.02SMP3Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YGR048W2.900.001890.10UFD1Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
YNL258C2.800.002550.05DSL1Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR175C5.852.50E-9RSM24Mitochondrial ribosomal protein of the small subunit
YLR318W5.413.19E-8EST2Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
YPR100W5.219.20E-8MRPL51Mitochondrial ribosomal protein of the large subunit
YBR233W5.052.23E-7PBP2RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress
YBL090W4.691.35E-6MRP21Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YGR042W_p4.611.99E-6YGR042W_pProtein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
YGR222W4.347.01E-6PET54Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
YDL006W4.289.32E-6PTC1Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
YCL074W4.251.06E-5YCL074WPseudogene: encodes fragment of Ty Pol protein
YOL019W-A_p4.191.42E-5YOL019W-A_pIdentified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR316C-A_p3.983.50E-5YMR316C-A_pProtein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W
YPR071W_p3.973.62E-5YPR071W_pPutative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
YJL063C3.934.17E-5MRPL8Mitochondrial ribosomal protein of the large subunit
YMR306W3.885.22E-5FKS3Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR188W3.865.63E-5MSB1Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress

GO enrichment analysis for SGTC_1289
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1071.35E-16SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.145455mitochondrial stress
0.0904.22E-12SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.0588235TRP & mitochondrial translation
0.0881.40E-11SGTC_1742st038235 28.9 μMTimTec (Natural product derivative library)5641030.132353mitochondrial stress
0.0823.02E-10SGTC_630099-0242 26.7 μMChemDiv (Drug-like library)38985020.0784314mitochondrial stress
0.0781.65E-9SGTC_6293448-6466 76.7 μMChemDiv (Drug-like library)5737440.178571
0.0782.35E-9SGTC_2361509-0011 5.3 μMChemDiv (Drug-like library)31072800.0677966
0.0773.35E-9SGTC_275trichlorophene 5.7 μMMiscellaneous626160.0816327mitochondrial stress
0.0741.26E-8SGTC_3101273-0058 1.1 μMChemDiv (Drug-like library)27342320.0588235mitochondrial stress
0.0663.69E-7SGTC_2745rifampicin 24.3 μMMiscellaneous251414280.0598291
0.0664.29E-7SGTC_6010986-0029 62.9 μMChemDiv (Drug-like library)247479810.226415calcium & mitochondrial duress
0.0664.47E-7SGTC_23916285546 200.0 μMChembridge (Fragment library)8460830.192308
0.0656.28E-7SGTC_11413253-0389 52.6 μMChemDiv (Drug-like library)54020310.16129
0.0621.65E-6SGTC_12850929-0069 65.5 μMChemDiv (Drug-like library)12062370.05
0.0621.74E-6SGTC_28pentachloropyridine N-oxide 1.6 μMChemDiv (Drug-like library)1402500.0243902TSC3-RPN4
0.0621.76E-6SGTC_6790422-0091 41.4 μMChemDiv (Drug-like library)6273840.0784314Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3260913710949.47 μM0.5517478346Chembridge (Drug-like library)255.311683.1561260S ribosome export
SGTC_12420402-010360.1 μM0.421053432868ChemDiv (Drug-like library)191.269482.3102
SGTC_29087930301100 μM0.4102562223178Chembridge (Drug-like library)387.431143.00533
SGTC_3310913022944.14 μM0.3877557761258Chembridge (Drug-like library)289.756743.8212Golgi
SGTC_3125912753449.47 μM0.3829791639235Chembridge (Drug-like library)283.364844.12812
SGTC_1210557-049561.34 μM0.3753104427ChemDiv (Drug-like library)436.481884.25923calcium & mitochondrial duress
SGTC_5700987-006562.6 μM0.3753104428ChemDiv (Drug-like library)436.481884.2592360S ribosome export
SGTC_15091326-113180 μM0.375768313ChemDiv (Drug-like library)239.312283.09402
SGTC_10553448-067286 μM0.369565748378ChemDiv (Drug-like library)302.369723.92412
SGTC_3091911637249.47 μM0.3617169793Chembridge (Drug-like library)285.337662.95313