1000-1494

(1-methylbenzimidazol-2-yl)-(2-nitrophenyl)methanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1294
Screen concentration 117.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 712797
SMILES CN1C2=CC=CC=C2N=C1C(=O)C3=CC=CC=C3[N+](=O)[O-]
Standardized SMILES Cn1c(nc2ccccc12)C(=O)c3ccccc3[N+](=O)[O-]
Molecular weight 281.2661
ALogP 3.26
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 22.7
% growth inhibition (Hom. pool) 10.78


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 712797
Download HIP data (tab-delimited text)  (excel)
Gene:DIS3(YOL021C)|FD-Score:3.39|P-value:3.46E-4|Clearance:0.06||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.06||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLE1(YDL207W)|FD-Score:44.6|P-value:0|Clearance:25.76||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:NUP57(YGR119C)|FD-Score:6.4|P-value:7.54E-11|Clearance:0.36||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PAB1(YER165W)|FD-Score:6.05|P-value:7.29E-10|Clearance:1.12||SGD DESC:Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G Gene:PKC1(YBL105C)|FD-Score:-4.49|P-value:3.53E-6|Clearance:0||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE8(YML092C)|FD-Score:4.93|P-value:4.20E-7|Clearance:1.06||SGD DESC:Alpha 2 subunit of the 20S proteasome Gene:SPC105(YGL093W)|FD-Score:18.8|P-value:3.26E-79|Clearance:6.31||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:WRS1(YOL097C)|FD-Score:3.87|P-value:5.45E-5|Clearance:0.48||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA Gene:YJL009W(YJL009W_d)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.2||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YTH1(YPR107C)|FD-Score:12.5|P-value:3.91E-36|Clearance:6.09||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:DIS3(YOL021C)|FD-Score:3.39|P-value:3.46E-4|Clearance:0.06||SGD DESC:Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.06||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLE1(YDL207W)|FD-Score:44.6|P-value:0|Clearance:25.76||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:NUP57(YGR119C)|FD-Score:6.4|P-value:7.54E-11|Clearance:0.36||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:PAB1(YER165W)|FD-Score:6.05|P-value:7.29E-10|Clearance:1.12||SGD DESC:Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G Gene:PKC1(YBL105C)|FD-Score:-4.49|P-value:3.53E-6|Clearance:0||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE8(YML092C)|FD-Score:4.93|P-value:4.20E-7|Clearance:1.06||SGD DESC:Alpha 2 subunit of the 20S proteasome Gene:SPC105(YGL093W)|FD-Score:18.8|P-value:3.26E-79|Clearance:6.31||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:WRS1(YOL097C)|FD-Score:3.87|P-value:5.45E-5|Clearance:0.48||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA Gene:YJL009W(YJL009W_d)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.2||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YTH1(YPR107C)|FD-Score:12.5|P-value:3.91E-36|Clearance:6.09||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 712797
Download HOP data (tab-delimited text)  (excel)
Gene:AAH1(YNL141W)|FD-Score:-3.72|P-value:9.82E-5||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:AIM1(YAL046C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALD3(YMR169C)|FD-Score:-3.31|P-value:4.64E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose Gene:ALG8(YOR067C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:ARO1(YDR127W)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATP11(YNL315C)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:BFR1(YOR198C)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:BOI1(YBL085W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:BUD3(YCL014W)|FD-Score:26.8|P-value:2.12E-158||SGD DESC:Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Gene:COS1(YNL336W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CTA1(YDR256C)|FD-Score:-3.51|P-value:2.26E-4||SGD DESC:Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation Gene:DIG1(YPL049C)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:EAF7(YNL136W)|FD-Score:10.8|P-value:1.04E-27||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:EMI1(YDR512C)|FD-Score:6.1|P-value:5.20E-10||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:FBP26(YJL155C)|FD-Score:14.2|P-value:8.40E-46||SGD DESC:Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress Gene:FRA1(YLL029W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation Gene:FYV10(YIL097W)|FD-Score:10.3|P-value:5.50E-25||SGD DESC:Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin Gene:GCV1(YDR019C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:GIM5(YML094W)|FD-Score:4.65|P-value:1.65E-6||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GIP1(YBR045C)|FD-Score:3.72|P-value:1.00E-4||SGD DESC:Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p Gene:HOS1(YPR068C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:HPR1(YDR138W)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:IRC25(YLR021W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:LDB16(YCL005W)|FD-Score:4.01|P-value:2.99E-5||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MDR1(YGR100W)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:MET31(YPL038W)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication Gene:MSA1(YOR066W)|FD-Score:8.02|P-value:5.16E-16||SGD DESC:Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation Gene:NCS6(YGL211W)|FD-Score:3.8|P-value:7.35E-5||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:OYE2(YHR179W)|FD-Score:7.21|P-value:2.89E-13||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:RGA2(YDR379W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p Gene:RNH203(YLR154C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RPL2A(YFR031C-A)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:SHE4(YOR035C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SNF5(YBR289W)|FD-Score:-4.69|P-value:1.34E-6||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions Gene:SPO20(YMR017W)|FD-Score:-3.45|P-value:2.79E-4||SGD DESC:Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog Gene:STF2(YGR008C)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TEP1(YNL128W)|FD-Score:8.4|P-value:2.32E-17||SGD DESC:PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 Gene:TRK1(YJL129C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:TRP5(YGL026C)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:URA10(YMR271C)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication Gene:URE2(YNL229C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion Gene:VAC17(YCL063W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p Gene:VHC1(YBR235W_p)|FD-Score:4.05|P-value:2.61E-5||SGD DESC:Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family Gene:VPS61(YDR136C_d)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:YBL055C(YBL055C)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR056W(YBR056W_p)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YDL183C(YDL183C)|FD-Score:12.9|P-value:4.09E-38||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR455C(YDR455C_d)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YDR509W(YDR509W_d)|FD-Score:3.94|P-value:4.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR524C-B(YDR524C-B_p)|FD-Score:3.92|P-value:4.40E-5||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YDR537C(YDR537C_d)|FD-Score:21.3|P-value:3.64E-101||SGD DESC:Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Gene:YEN1(YER041W)|FD-Score:18|P-value:4.61E-73||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YFH7(YFR007W)|FD-Score:27.8|P-value:7.69E-170||SGD DESC:Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases Gene:YGL159W(YGL159W_p)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YHR131C(YHR131C_p)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study Gene:YIL089W(YIL089W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking Gene:YJL193W(YJL193W_p)|FD-Score:12.9|P-value:1.32E-38||SGD DESC:Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect Gene:YJR129C(YJR129C_p)|FD-Score:21.8|P-value:4.94E-106||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YJR149W(YJR149W_p)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YNL319W(YNL319W_d)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Gene:YOR277C(YOR277C_d)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPR027C(YPR027C_p)|FD-Score:4.16|P-value:1.61E-5||SGD DESC:Putative protein of unknown function Gene:YPR097W(YPR097W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR146C(YPR146C_d)|FD-Score:11.8|P-value:2.81E-32||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR174C(YPR174C_p)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication Gene:YPR197C(YPR197C_d)|FD-Score:12.5|P-value:3.18E-36||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:AAH1(YNL141W)|FD-Score:-3.72|P-value:9.82E-5||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:AIM1(YAL046C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALD3(YMR169C)|FD-Score:-3.31|P-value:4.64E-4||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose Gene:ALG8(YOR067C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:ARO1(YDR127W)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATP11(YNL315C)|FD-Score:3.38|P-value:3.62E-4||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:BFR1(YOR198C)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity Gene:BOI1(YBL085W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:BUD3(YCL014W)|FD-Score:26.8|P-value:2.12E-158||SGD DESC:Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Gene:COS1(YNL336W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CTA1(YDR256C)|FD-Score:-3.51|P-value:2.26E-4||SGD DESC:Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation Gene:DIG1(YPL049C)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:EAF7(YNL136W)|FD-Score:10.8|P-value:1.04E-27||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:EMI1(YDR512C)|FD-Score:6.1|P-value:5.20E-10||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:FBP26(YJL155C)|FD-Score:14.2|P-value:8.40E-46||SGD DESC:Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress Gene:FRA1(YLL029W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation Gene:FYV10(YIL097W)|FD-Score:10.3|P-value:5.50E-25||SGD DESC:Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin Gene:GCV1(YDR019C)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:GIM5(YML094W)|FD-Score:4.65|P-value:1.65E-6||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GIP1(YBR045C)|FD-Score:3.72|P-value:1.00E-4||SGD DESC:Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p Gene:HOS1(YPR068C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:HPR1(YDR138W)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:IRC25(YLR021W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:LDB16(YCL005W)|FD-Score:4.01|P-value:2.99E-5||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MDR1(YGR100W)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:MET31(YPL038W)|FD-Score:-3.69|P-value:1.14E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication Gene:MSA1(YOR066W)|FD-Score:8.02|P-value:5.16E-16||SGD DESC:Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation Gene:NCS6(YGL211W)|FD-Score:3.8|P-value:7.35E-5||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:OYE2(YHR179W)|FD-Score:7.21|P-value:2.89E-13||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:RGA2(YDR379W)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p Gene:RNH203(YLR154C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:RPL2A(YFR031C-A)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:SHE4(YOR035C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SNF5(YBR289W)|FD-Score:-4.69|P-value:1.34E-6||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions Gene:SPO20(YMR017W)|FD-Score:-3.45|P-value:2.79E-4||SGD DESC:Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog Gene:STF2(YGR008C)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress Gene:TEP1(YNL128W)|FD-Score:8.4|P-value:2.32E-17||SGD DESC:PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 Gene:TRK1(YJL129C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:TRP5(YGL026C)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:URA10(YMR271C)|FD-Score:-3.25|P-value:5.87E-4||SGD DESC:Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication Gene:URE2(YNL229C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion Gene:VAC17(YCL063W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p Gene:VHC1(YBR235W_p)|FD-Score:4.05|P-value:2.61E-5||SGD DESC:Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family Gene:VPS61(YDR136C_d)|FD-Score:4.13|P-value:1.83E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:YBL055C(YBL055C)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR056W(YBR056W_p)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YDL183C(YDL183C)|FD-Score:12.9|P-value:4.09E-38||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR455C(YDR455C_d)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YDR509W(YDR509W_d)|FD-Score:3.94|P-value:4.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR524C-B(YDR524C-B_p)|FD-Score:3.92|P-value:4.40E-5||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YDR537C(YDR537C_d)|FD-Score:21.3|P-value:3.64E-101||SGD DESC:Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Gene:YEN1(YER041W)|FD-Score:18|P-value:4.61E-73||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YFH7(YFR007W)|FD-Score:27.8|P-value:7.69E-170||SGD DESC:Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases Gene:YGL159W(YGL159W_p)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YHR131C(YHR131C_p)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study Gene:YIL089W(YIL089W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking Gene:YJL193W(YJL193W_p)|FD-Score:12.9|P-value:1.32E-38||SGD DESC:Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect Gene:YJR129C(YJR129C_p)|FD-Score:21.8|P-value:4.94E-106||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YJR149W(YJR149W_p)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YNL319W(YNL319W_d)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Gene:YOR277C(YOR277C_d)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPR027C(YPR027C_p)|FD-Score:4.16|P-value:1.61E-5||SGD DESC:Putative protein of unknown function Gene:YPR097W(YPR097W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR146C(YPR146C_d)|FD-Score:11.8|P-value:2.81E-32||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR174C(YPR174C_p)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication Gene:YPR197C(YPR197C_d)|FD-Score:12.5|P-value:3.18E-36||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL207W44.60025.80GLE1Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
YGL093W18.803.26E-796.31SPC105Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
YPR107C12.503.91E-366.09YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YGR119C6.407.54E-110.36NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YER165W6.057.29E-101.12PAB1Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
YML092C4.934.20E-71.06PRE8Alpha 2 subunit of the 20S proteasome
YOL097C3.875.45E-50.48WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YOL021C3.393.46E-40.06DIS3Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
YJL009W_d3.334.28E-40.20YJL009W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YHR007C3.138.74E-40.06ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YMR314W3.070.001080.06PRE5Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YGL122C3.000.001340.00NAB2Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
YOR319W3.000.001350.18HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YFR002W2.820.002420.06NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YNL132W2.760.002880.05KRE33Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFR007W27.807.69E-170YFH7Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
YCL014W26.802.12E-158BUD3Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YJR129C_p21.804.94E-106YJR129C_pPutative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR537C_d21.303.64E-101YDR537C_dDubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
YER041W18.004.61E-73YEN1Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
YJL155C14.208.40E-46FBP26Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
YJL193W_p12.901.32E-38YJL193W_pPutative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YDL183C12.904.09E-38YDL183CMitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
YPR197C_d12.503.18E-36YPR197C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR146C_d11.802.81E-32YPR146C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL136W10.801.04E-27EAF7Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
YIL097W10.305.50E-25FYV10Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
YNL128W8.402.32E-17TEP1PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
YOR066W8.025.16E-16MSA1Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
YHR179W7.212.89E-13OYE2Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_1294
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.3592.84E-179SGTC_1070358-0022 2.7 μMChemDiv (Drug-like library)5211060.0909091SWF1 & branched chain AA biosynthesis
0.3443.68E-164SGTC_30591327-0034 3.0 μMChemDiv (Drug-like library)159985800.157143
0.3238.63E-143SGTC_30601327-0027 12.5 μMChemDiv (Drug-like library)160004550.191176
0.3232.17E-143SGTC_794k038-0031 316.0 μMChemDiv (Drug-like library)66242420.0533333ubiquinone biosynthesis & proteasome
0.3209.76E-141SGTC_24295902844 64.4 μMMiscellaneous19277900.0909091
0.3144.91E-134SGTC_30631327-0034 4.0 μMChemDiv (Drug-like library)159985800.157143
0.2873.89E-112SGTC_340k038-0059 454.0 μMChemDiv (Drug-like library)237334240.0405405ubiquinone biosynthesis & proteasome
0.2691.42E-98SGTC_1420335-0849 62.7 μMChemDiv (Drug-like library)38890430.140845ubiquinone biosynthesis & proteasome
0.2523.25E-86SGTC_860417-1630 471.9 μMChemDiv (Drug-like library)36348670.0506329ubiquinone biosynthesis & proteasome
0.2436.88E-80SGTC_158k038-0087 26.4 μMChemDiv (Drug-like library)X1580.0675676ubiquinone biosynthesis & proteasome
0.2413.20E-78SGTC_30641327-0027 10.0 μMChemDiv (Drug-like library)160004550.191176
0.2302.03E-71SGTC_1370438-0332 85.4 μMChemDiv (Drug-like library)20633930.0517241ubiquinone biosynthesis & proteasome
0.2069.73E-58SGTC_64000l-0018 272.1 μMChemDiv (Drug-like library)68111190.0481928ubiquinone biosynthesis & proteasome
0.1939.70E-51SGTC_294k038-0071 157.0 μMChemDiv (Drug-like library)241528260.0555556ubiquinone biosynthesis & proteasome
0.1891.36E-48SGTC_1030844-0104 51.8 μMChemDiv (Drug-like library)53758040.15ERAD & cell cycle

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_13511496-000346.5 μM0.3518523891978ChemDiv (Drug-like library)330.212642.908
SGTC_2427554505542.75 μM0.3090915372858Miscellaneous250.298463.71113
SGTC_3288911969036.22 μM0.29508217595618Chembridge (Drug-like library)295.378843.00702
SGTC_12730849-009614.1 μM0.2857145286025ChemDiv (Drug-like library)216.235882.82302RPP1 & pyrimidine depletion
SGTC_1764st04450293.5 μM0.2857148407TimTec (Natural product derivative library)214.223.27413
SGTC_8470342-02745.54 μM0.2818097ChemDiv (Drug-like library)218.165641.28204
SGTC_1091telmisartan47.6 μM0.27848165999Miscellaneous514.61697.79914
SGTC_7223534-0461190 μM0.274194658262ChemDiv (Drug-like library)293.362963.9512PDR1
SGTC_3051682-259520.8 μM0.272727226033ChemDiv (Drug-like library)260.311584.35114RNA processing & uracil transport
SGTC_3017908068149.47 μM0.26984116451914Chembridge (Drug-like library)307.389543.14702