1079-1439

1,2,4-trichloro-8-nitrophenoxazin-3-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1299
Screen concentration 3.7 μM
Source ChemDiv (Drug-like library)
PubChem CID 323161
SMILES C1=CC2=C(C=C1[N+](=O)[O-])N=C3C(=C(C(=O)C(=C3Cl)Cl)Cl)O2
Standardized SMILES [O-][N+](=O)c1ccc2OC3=C(Cl)C(=O)C(=C(Cl)C3=Nc2c1)Cl
Molecular weight 345.5222
ALogP 2.96
H-bond donor count 0
H-bond acceptor count 5
Response signature TSC3-RPN4

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.12
% growth inhibition (Hom. pool) 1.02


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 323161
Download HIP data (tab-delimited text)  (excel)
Gene:ARC40(YBR234C)|FD-Score:-4.09|P-value:2.17E-5|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:EPL1(YFL024C)|FD-Score:3.9|P-value:4.83E-5|Clearance:0.16||SGD DESC:Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb Gene:ERG11(YHR007C)|FD-Score:3.1|P-value:9.75E-4|Clearance:0.01||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLC7(YER133W)|FD-Score:3.11|P-value:9.41E-4|Clearance:0.01||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GRS1(YBR121C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.02||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:MAS2(YHR024C)|FD-Score:3.09|P-value:9.91E-4|Clearance:0.1||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MRD1(YPR112C)|FD-Score:-3.31|P-value:4.66E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:MTR10(YOR160W)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.25||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NAR1(YNL240C)|FD-Score:-3.75|P-value:9.00E-5|Clearance:0||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PTI1(YGR156W)|FD-Score:3.44|P-value:2.94E-4|Clearance:0.06||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RPA43(YOR340C)|FD-Score:4.18|P-value:1.44E-5|Clearance:0.28||SGD DESC:RNA polymerase I subunit A43 Gene:RPB10(YOR210W)|FD-Score:5.29|P-value:5.97E-8|Clearance:1.11||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC40(YPR110C)|FD-Score:3.66|P-value:1.28E-4|Clearance:0.03||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPN12(YFR052W)|FD-Score:-3.19|P-value:7.10E-4|Clearance:0||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:UBA1(YKL210W)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.19||SGD DESC:Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress Gene:VRG4(YGL225W)|FD-Score:3.73|P-value:9.42E-5|Clearance:0.08||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:ARC40(YBR234C)|FD-Score:-4.09|P-value:2.17E-5|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:EPL1(YFL024C)|FD-Score:3.9|P-value:4.83E-5|Clearance:0.16||SGD DESC:Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb Gene:ERG11(YHR007C)|FD-Score:3.1|P-value:9.75E-4|Clearance:0.01||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLC7(YER133W)|FD-Score:3.11|P-value:9.41E-4|Clearance:0.01||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GRS1(YBR121C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.02||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:MAS2(YHR024C)|FD-Score:3.09|P-value:9.91E-4|Clearance:0.1||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MRD1(YPR112C)|FD-Score:-3.31|P-value:4.66E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:MTR10(YOR160W)|FD-Score:3.38|P-value:3.68E-4|Clearance:0.25||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NAR1(YNL240C)|FD-Score:-3.75|P-value:9.00E-5|Clearance:0||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PTI1(YGR156W)|FD-Score:3.44|P-value:2.94E-4|Clearance:0.06||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RPA43(YOR340C)|FD-Score:4.18|P-value:1.44E-5|Clearance:0.28||SGD DESC:RNA polymerase I subunit A43 Gene:RPB10(YOR210W)|FD-Score:5.29|P-value:5.97E-8|Clearance:1.11||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC40(YPR110C)|FD-Score:3.66|P-value:1.28E-4|Clearance:0.03||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPN12(YFR052W)|FD-Score:-3.19|P-value:7.10E-4|Clearance:0||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:UBA1(YKL210W)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.19||SGD DESC:Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress Gene:VRG4(YGL225W)|FD-Score:3.73|P-value:9.42E-5|Clearance:0.08||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 323161
Download HOP data (tab-delimited text)  (excel)
Gene:AGP1(YCL025C)|FD-Score:3.23|P-value:6.10E-4||SGD DESC:Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication Gene:ARL3(YPL051W)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ARO1(YDR127W)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ASC1(YMR116C)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation Gene:ATP5(YDR298C)|FD-Score:-3.43|P-value:3.04E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:COR1(YBL045C)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain Gene:DCC1(YCL016C)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:EFT1(YOR133W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:ELM1(YKL048C)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:EMP24(YGL200C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:ERV14(YGL054C)|FD-Score:3.1|P-value:9.57E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FCY1(YPR062W)|FD-Score:3.32|P-value:4.47E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:GAL3(YDR009W)|FD-Score:-4|P-value:3.16E-5||SGD DESC:Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication Gene:GRH1(YDR517W)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:HBT1(YDL223C)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HIM1(YDR317W)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Protein of unknown function involved in DNA repair Gene:KSP1(YHR082C)|FD-Score:-3.24|P-value:5.94E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LIP2(YLR239C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups Gene:MAP2(YBL091C)|FD-Score:5.72|P-value:5.28E-9||SGD DESC:Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p Gene:MF(ALPHA)2(YGL089C)|FD-Score:4.49|P-value:3.58E-6||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 Gene:MIR1(YJR077C)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated Gene:MPM1(YJL066C)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MSL1(YIR009W)|FD-Score:4.74|P-value:1.05E-6||SGD DESC:U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members Gene:MXR1(YER042W)|FD-Score:-3.86|P-value:5.62E-5||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NPL4(YBR170C)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) Gene:PHO8(YDR481C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN Gene:PRO2(YOR323C)|FD-Score:4.31|P-value:8.14E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RNR3(YIL066C)|FD-Score:3.39|P-value:3.43E-4||SGD DESC:Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits Gene:RPN10(YHR200W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein Gene:RTC6(YPL183W-A)|FD-Score:-3.11|P-value:9.48E-4||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SCD6(YPR129W)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SFT2(YBL102W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SHY1(YGR112W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome Gene:SIS2(YKR072C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SNX4(YJL036W)|FD-Score:3.12|P-value:9.02E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SOL4(YGR248W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:SVF1(YDR346C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance Gene:TAT1(YBR069C)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TAT2(YOL020W)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TBS1(YBR150C)|FD-Score:4.9|P-value:4.72E-7||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication Gene:THR1(YHR025W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TSC3(YBR058C-A)|FD-Score:33.9|P-value:6.30E-253||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VPS61(YDR136C_d)|FD-Score:-3.84|P-value:6.22E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:VPS69(YPR087W_d)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Gene:YAL018C(YAL018C_p)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Putative protein of unknown function Gene:YAL037C-A(YAL037C-A_p)|FD-Score:3.1|P-value:9.79E-4||SGD DESC:Putative protein of unknown function Gene:YBR259W(YBR259W_p)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCR085W(YCR085W_d)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR101C(YCR101C_p)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YGL177W(YGL177W_d)|FD-Score:4.14|P-value:1.75E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL024C(YIL024C_p)|FD-Score:4.54|P-value:2.82E-6||SGD DESC:Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p Gene:YIR035C(YIR035C_p)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Putative cytoplasmic short-chain dehydrogenase/reductase Gene:YJL070C(YJL070C_p)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YLL007C(YLL007C_p)|FD-Score:3.95|P-value:3.90E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR282C(YLR282C_d)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YMR209C(YMR209C_p)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene Gene:YOR296W(YOR296W_p)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene Gene:YOR376W-A(YOR376W-A_p)|FD-Score:-3.09|P-value:9.99E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPR012W(YPR012W_d)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Gene:AGP1(YCL025C)|FD-Score:3.23|P-value:6.10E-4||SGD DESC:Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication Gene:ARL3(YPL051W)|FD-Score:3.72|P-value:9.84E-5||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ARO1(YDR127W)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ASC1(YMR116C)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation Gene:ATP5(YDR298C)|FD-Score:-3.43|P-value:3.04E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:COR1(YBL045C)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain Gene:DCC1(YCL016C)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:EFT1(YOR133W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:ELM1(YKL048C)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:EMP24(YGL200C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles Gene:ERV14(YGL054C)|FD-Score:3.1|P-value:9.57E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FCY1(YPR062W)|FD-Score:3.32|P-value:4.47E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:GAL3(YDR009W)|FD-Score:-4|P-value:3.16E-5||SGD DESC:Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication Gene:GRH1(YDR517W)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:HBT1(YDL223C)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HIM1(YDR317W)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Protein of unknown function involved in DNA repair Gene:KSP1(YHR082C)|FD-Score:-3.24|P-value:5.94E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LIP2(YLR239C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups Gene:MAP2(YBL091C)|FD-Score:5.72|P-value:5.28E-9||SGD DESC:Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p Gene:MF(ALPHA)2(YGL089C)|FD-Score:4.49|P-value:3.58E-6||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 Gene:MIR1(YJR077C)|FD-Score:3.63|P-value:1.40E-4||SGD DESC:Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated Gene:MPM1(YJL066C)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MSL1(YIR009W)|FD-Score:4.74|P-value:1.05E-6||SGD DESC:U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members Gene:MXR1(YER042W)|FD-Score:-3.86|P-value:5.62E-5||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NPL4(YBR170C)|FD-Score:3.55|P-value:1.94E-4||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) Gene:PHO8(YDR481C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN Gene:PRO2(YOR323C)|FD-Score:4.31|P-value:8.14E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RNR3(YIL066C)|FD-Score:3.39|P-value:3.43E-4||SGD DESC:Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits Gene:RPN10(YHR200W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein Gene:RTC6(YPL183W-A)|FD-Score:-3.11|P-value:9.48E-4||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SCD6(YPR129W)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SFT2(YBL102W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SHY1(YGR112W)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome Gene:SIS2(YKR072C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SNX4(YJL036W)|FD-Score:3.12|P-value:9.02E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SOL4(YGR248W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:SVF1(YDR346C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance Gene:TAT1(YBR069C)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TAT2(YOL020W)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TBS1(YBR150C)|FD-Score:4.9|P-value:4.72E-7||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication Gene:THR1(YHR025W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TSC3(YBR058C-A)|FD-Score:33.9|P-value:6.30E-253||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VPS61(YDR136C_d)|FD-Score:-3.84|P-value:6.22E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:VPS69(YPR087W_d)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Gene:YAL018C(YAL018C_p)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Putative protein of unknown function Gene:YAL037C-A(YAL037C-A_p)|FD-Score:3.1|P-value:9.79E-4||SGD DESC:Putative protein of unknown function Gene:YBR259W(YBR259W_p)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCR085W(YCR085W_d)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR101C(YCR101C_p)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YGL177W(YGL177W_d)|FD-Score:4.14|P-value:1.75E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL024C(YIL024C_p)|FD-Score:4.54|P-value:2.82E-6||SGD DESC:Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p Gene:YIR035C(YIR035C_p)|FD-Score:-3.5|P-value:2.30E-4||SGD DESC:Putative cytoplasmic short-chain dehydrogenase/reductase Gene:YJL070C(YJL070C_p)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YLL007C(YLL007C_p)|FD-Score:3.95|P-value:3.90E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR282C(YLR282C_d)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YMR209C(YMR209C_p)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene Gene:YOR296W(YOR296W_p)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene Gene:YOR376W-A(YOR376W-A_p)|FD-Score:-3.09|P-value:9.99E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPR012W(YPR012W_d)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR210W5.295.97E-81.11RPB10RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
YOR340C4.181.44E-50.28RPA43RNA polymerase I subunit A43
YFL024C3.904.83E-50.17EPL1Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
YGL225W3.739.42E-50.08VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YPR110C3.661.28E-40.03RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YKL210W3.631.42E-40.19UBA1Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
YGR156W3.442.94E-40.06PTI1Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YOR160W3.383.68E-40.24MTR10Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YBR121C3.138.74E-40.02GRS1Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
YER133W3.119.41E-40.01GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YHR007C3.109.75E-40.01ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YHR024C3.099.91E-40.10MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YKR068C2.990.001390.06BET3Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
YMR208W2.940.001660.13ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YLR314C2.810.002500.04CDC3Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR058C-A33.906.30E-253TSC3Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YBL091C5.725.28E-9MAP2Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
YBR150C4.904.72E-7TBS1Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
YIR009W4.741.05E-6MSL1U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
YIL024C_p4.542.82E-6YIL024C_pPutative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YGL089C4.493.58E-6MF(ALPHA)2Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YOR323C4.318.14E-6PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YGR248W4.181.46E-5SOL46-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
YJL066C4.171.53E-5MPM1Mitochondrial intermembrane space protein of unknown function
YGL177W_d4.141.75E-5YGL177W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL007C_p3.953.90E-5YLL007C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene
YPL051W3.729.84E-5ARL3GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
YHR025W3.671.20E-4THR1Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YDR317W3.671.24E-4HIM1Protein of unknown function involved in DNA repair
YMR209C_p3.651.34E-4YMR209C_pPutative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene

GO enrichment analysis for SGTC_1299
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.6100SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.0294118TSC3-RPN4
0.5910SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.101266TSC3-RPN4
0.5840SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 μMTimTec (Natural product derivative library)7563770.176471TSC3-RPN4
0.5700SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.0588235TSC3-RPN4
0.5540SGTC_520329-0193 875.0 nMChemDiv (Drug-like library)37392920.209677TSC3-RPN4
0.5140SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.107692TSC3-RPN4
0.5080SGTC_1919st067113 52.3 μMTimTec (Natural product derivative library)12682430.125TSC3-RPN4
0.5010SGTC_8850865-0106 16.8 μMChemDiv (Drug-like library)27933800.114754TSC3-RPN4
0.4880SGTC_320928-0142 34.1 μMChemDiv (Drug-like library)22442420.0833333TSC3-RPN4
0.4810SGTC_9851493-0307 8.7 μMChemDiv (Drug-like library)32782740.0769231TSC3-RPN4
0.4720SGTC_22186965428 193.0 μMChembridge (Fragment library)6756840.0289855TSC3-RPN4
0.4650SGTC_11730443-0020 122.0 μMChemDiv (Drug-like library)53312950.057971TSC3-RPN4
0.4591.20E-305SGTC_1813st051246 8.6 μMTimTec (Natural product derivative library)52919590.206897TSC3-RPN4
0.4562.11E-300SGTC_1662st014054 52.0 μMTimTec (Natural product derivative library)28387770.111111TSC3-RPN4
0.4495.35E-291SGTC_7901575-0012 79.1 μMChemDiv (Drug-like library)3787410.0769231TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1360097-0015404.48 μM0.344861337ChemDiv (Drug-like library)494.448642.62701160S ribosome export
SGTC_3710195-00067.36 μM0.3333333928593ChemDiv (Drug-like library)253.209682.70204
SGTC_7450469-0705296 μM0.3050853486736ChemDiv (Drug-like library)238.153741.86706mitochondrial processes
SGTC_1028k015-00294.8 μM0.2903234588309ChemDiv (Drug-like library)351.141023.68304
SGTC_2361509-00115.31 μM0.2807023107280ChemDiv (Drug-like library)295.20662.5906
SGTC_3861509-00113.07 μM0.2807023107280ChemDiv (Drug-like library)295.20662.5906
SGTC_1457k015-003257.3 μM0.2727274302660ChemDiv (Drug-like library)334.6864233.22405
SGTC_1920st07572845.7 μM0.2676063400306TimTec (Natural product derivative library)314.292763.2615
SGTC_12480469-068758.6 μM0.2666674017482ChemDiv (Drug-like library)284.223722.88805
SGTC_5961155-0152116 μM0.264151280313ChemDiv (Drug-like library)176.172022.16312TRP & mitochondrial translation
SGTC_7930488-0545106 μM0.259259292548ChemDiv (Drug-like library)237.212042.24105