Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR140W | 10.20 | 1.28E-24 | MTQ2 | S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC |
YPR198W | 6.94 | 1.95E-12 | SGE1 | Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations |
YOR365C_p | 6.23 | 2.34E-10 | YOR365C_p | Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication |
YOL065C | 5.92 | 1.65E-9 | INP54 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins |
YOR238W_p | 5.53 | 1.62E-8 | YOR238W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YMR216C | 5.35 | 4.35E-8 | SKY1 | SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 |
YJR031C | 5.32 | 5.11E-8 | GEA1 | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication |
YPL144W | 5.27 | 6.75E-8 | POC4 | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
YHR121W | 5.12 | 1.49E-7 | LSM12 | Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress |
YPL049C | 5.01 | 2.78E-7 | DIG1 | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
YOR300W_d | 4.90 | 4.75E-7 | YOR300W_d | Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 |
YLL045C | 4.68 | 1.44E-6 | RPL8B | Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication |
YPL267W | 4.47 | 3.88E-6 | ACM1 | Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein |
YPR197C_d | 4.43 | 4.71E-6 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YMR252C_p | 4.33 | 7.59E-6 | YMR252C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene |