Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR074C | 7.49 | 3.55E-14 | TKL1 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
YIR024C | 5.86 | 2.33E-9 | YIR024C | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect |
YDR306C_p | 5.26 | 7.36E-8 | YDR306C_p | F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain |
YBR194W | 4.60 | 2.09E-6 | AIM4 | Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress |
YOR334W | 4.57 | 2.43E-6 | MRS2 | Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns |
YGR039W_d | 4.57 | 2.49E-6 | YGR039W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 |
YBR183W | 4.53 | 2.92E-6 | YPC1 | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication |
YMR052C-A_d | 4.50 | 3.46E-6 | YMR052C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL120W_d | 4.20 | 1.31E-5 | YJL120W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
YMR038C | 4.12 | 1.90E-5 | CCS1 | Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress |
YNL319W_d | 4.09 | 2.17E-5 | YNL319W_d | Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 |
YDR129C | 4.00 | 3.11E-5 | SAC6 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YBL095W_p | 3.81 | 7.00E-5 | YBL095W_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YDL115C | 3.76 | 8.45E-5 | IWR1 | RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress |
YJR104C | 3.70 | 1.10E-4 | SOD1 | Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid |