1187-1599

4-[1-(4-ethoxyphenyl)cyclohexyl]phenol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1307
Screen concentration 12.2 μM
Source ChemDiv (Drug-like library)
PubChem CID 1538471
SMILES CCOC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)O
Standardized SMILES CCOc1ccc(cc1)C2(CCCCC2)c3ccc(O)cc3
Molecular weight 296.4034
ALogP 5.35
H-bond donor count 1
H-bond acceptor count 2
Response signature PDR1

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.36
% growth inhibition (Hom. pool) 7.87


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1538471
Download HIP data (tab-delimited text)  (excel)
Gene:BIG1(YHR101C)|FD-Score:3.8|P-value:7.11E-5|Clearance:0.16||SGD DESC:Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan Gene:CCT3(YJL014W)|FD-Score:5.93|P-value:1.54E-9|Clearance:1.41||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CCT4(YDL143W)|FD-Score:3.35|P-value:4.10E-4|Clearance:0.07||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NBP35(YGL091C)|FD-Score:3.28|P-value:5.28E-4|Clearance:0.19||SGD DESC:Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases Gene:NIC96(YFR002W)|FD-Score:4.51|P-value:3.17E-6|Clearance:0.26||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:PBN1(YCL052C)|FD-Score:-4.98|P-value:3.14E-7|Clearance:0||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:RLP24(YLR009W)|FD-Score:3.64|P-value:1.34E-4|Clearance:0.08||SGD DESC:Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp Gene:RPC82(YPR190C)|FD-Score:3.48|P-value:2.53E-4|Clearance:0.11||SGD DESC:RNA polymerase III subunit C82 Gene:SUI2(YJR007W)|FD-Score:4.25|P-value:1.05E-5|Clearance:0.45||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:YJL086C(YJL086C_d)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YPL142C(YPL142C_d)|FD-Score:3.56|P-value:1.82E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Gene:BIG1(YHR101C)|FD-Score:3.8|P-value:7.11E-5|Clearance:0.16||SGD DESC:Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan Gene:CCT3(YJL014W)|FD-Score:5.93|P-value:1.54E-9|Clearance:1.41||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CCT4(YDL143W)|FD-Score:3.35|P-value:4.10E-4|Clearance:0.07||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:NBP35(YGL091C)|FD-Score:3.28|P-value:5.28E-4|Clearance:0.19||SGD DESC:Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases Gene:NIC96(YFR002W)|FD-Score:4.51|P-value:3.17E-6|Clearance:0.26||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:PBN1(YCL052C)|FD-Score:-4.98|P-value:3.14E-7|Clearance:0||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:RLP24(YLR009W)|FD-Score:3.64|P-value:1.34E-4|Clearance:0.08||SGD DESC:Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp Gene:RPC82(YPR190C)|FD-Score:3.48|P-value:2.53E-4|Clearance:0.11||SGD DESC:RNA polymerase III subunit C82 Gene:SUI2(YJR007W)|FD-Score:4.25|P-value:1.05E-5|Clearance:0.45||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:YJL086C(YJL086C_d)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YPL142C(YPL142C_d)|FD-Score:3.56|P-value:1.82E-4|Clearance:0.09||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1538471
Download HOP data (tab-delimited text)  (excel)
Gene:AIM4(YBR194W)|FD-Score:4.27|P-value:9.81E-6||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:ARG1(YOL058W)|FD-Score:5.27|P-value:6.98E-8||SGD DESC:Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate Gene:ARO1(YDR127W)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARR3(YPR201W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:BDS1(YOL164W)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources Gene:BNI4(YNL233W)|FD-Score:3.21|P-value:6.70E-4||SGD DESC:Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p Gene:BUL1(YMR275C)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:BUL2(YML111W)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication Gene:CEM1(YER061C)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CMC1(YKL137W)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif Gene:COA1(YIL157C)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:DSS4(YPR017C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:GOS1(YHL031C)|FD-Score:5.4|P-value:3.37E-8||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:KAR4(YCL055W)|FD-Score:-3.42|P-value:3.19E-4||SGD DESC:Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone Gene:MAK32(YCR019W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MFM1(YPL060W)|FD-Score:9.15|P-value:2.94E-20||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MSI1(YBR195C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase Gene:MTM1(YGR257C)|FD-Score:3.86|P-value:5.56E-5||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:PBS2(YJL128C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PDR1(YGL013C)|FD-Score:7.38|P-value:8.02E-14||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PHO8(YDR481C)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN Gene:PPR1(YLR014C)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:PTR2(YKR093W)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:QCR7(YDR529C)|FD-Score:3.77|P-value:8.27E-5||SGD DESC:Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly Gene:RAD10(YML095C)|FD-Score:-3.69|P-value:1.10E-4||SGD DESC:Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein Gene:RKM5(YLR137W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species Gene:RPN4(YDL020C)|FD-Score:5.62|P-value:9.69E-9||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SDS3(YIL084C)|FD-Score:-3.27|P-value:5.46E-4||SGD DESC:Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes Gene:SEG2(YKL105C_p)|FD-Score:-3.16|P-value:7.84E-4||SGD DESC:Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes Gene:SNF5(YBR289W)|FD-Score:-5.88|P-value:2.01E-9||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions Gene:SOM1(YEL059C-A)|FD-Score:3.85|P-value:5.83E-5||SGD DESC:Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs Gene:SRO77(YBL106C)|FD-Score:5.43|P-value:2.82E-8||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SSH4(YKL124W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases Gene:SUR4(YLR372W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:TIM11(YDR322C-A)|FD-Score:-3.12|P-value:9.11E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:TPK2(YPL203W)|FD-Score:4.34|P-value:7.19E-6||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase Gene:UPC2(YDR213W)|FD-Score:-3.43|P-value:2.98E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YBR064W(YBR064W_d)|FD-Score:-3.83|P-value:6.41E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Gene:YBR259W(YBR259W_p)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCK2(YNL154C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YKL106C-A(YKL106C-A_p)|FD-Score:-4.3|P-value:8.40E-6||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YKR051W(YKR051W_p)|FD-Score:-3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function Gene:YLR124W(YLR124W_d)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL118C(YOL118C_d)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR059C(YPR059C_d)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:ZIP2(YGL249W)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:AIM4(YBR194W)|FD-Score:4.27|P-value:9.81E-6||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:ARG1(YOL058W)|FD-Score:5.27|P-value:6.98E-8||SGD DESC:Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate Gene:ARO1(YDR127W)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARR3(YPR201W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:BDS1(YOL164W)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources Gene:BNI4(YNL233W)|FD-Score:3.21|P-value:6.70E-4||SGD DESC:Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p Gene:BUL1(YMR275C)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:BUL2(YML111W)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication Gene:CEM1(YER061C)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CMC1(YKL137W)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif Gene:COA1(YIL157C)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:DSS4(YPR017C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:GOS1(YHL031C)|FD-Score:5.4|P-value:3.37E-8||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:KAR4(YCL055W)|FD-Score:-3.42|P-value:3.19E-4||SGD DESC:Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone Gene:MAK32(YCR019W)|FD-Score:-3.18|P-value:7.26E-4||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MFM1(YPL060W)|FD-Score:9.15|P-value:2.94E-20||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MSI1(YBR195C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase Gene:MTM1(YGR257C)|FD-Score:3.86|P-value:5.56E-5||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:PBS2(YJL128C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PDR1(YGL013C)|FD-Score:7.38|P-value:8.02E-14||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PHO8(YDR481C)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN Gene:PPR1(YLR014C)|FD-Score:3.32|P-value:4.49E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:PTR2(YKR093W)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:QCR7(YDR529C)|FD-Score:3.77|P-value:8.27E-5||SGD DESC:Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly Gene:RAD10(YML095C)|FD-Score:-3.69|P-value:1.10E-4||SGD DESC:Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein Gene:RKM5(YLR137W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species Gene:RPN4(YDL020C)|FD-Score:5.62|P-value:9.69E-9||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SDS3(YIL084C)|FD-Score:-3.27|P-value:5.46E-4||SGD DESC:Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes Gene:SEG2(YKL105C_p)|FD-Score:-3.16|P-value:7.84E-4||SGD DESC:Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes Gene:SNF5(YBR289W)|FD-Score:-5.88|P-value:2.01E-9||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions Gene:SOM1(YEL059C-A)|FD-Score:3.85|P-value:5.83E-5||SGD DESC:Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs Gene:SRO77(YBL106C)|FD-Score:5.43|P-value:2.82E-8||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:SSH4(YKL124W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases Gene:SUR4(YLR372W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:TIM11(YDR322C-A)|FD-Score:-3.12|P-value:9.11E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:TPK2(YPL203W)|FD-Score:4.34|P-value:7.19E-6||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase Gene:UPC2(YDR213W)|FD-Score:-3.43|P-value:2.98E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YBR064W(YBR064W_d)|FD-Score:-3.83|P-value:6.41E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Gene:YBR259W(YBR259W_p)|FD-Score:3.17|P-value:7.54E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YCK2(YNL154C)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YKL106C-A(YKL106C-A_p)|FD-Score:-4.3|P-value:8.40E-6||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YKR051W(YKR051W_p)|FD-Score:-3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function Gene:YLR124W(YLR124W_d)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL118C(YOL118C_d)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR059C(YPR059C_d)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Gene:ZIP2(YGL249W)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL014W5.931.54E-91.41CCT3Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YFR002W4.513.17E-60.26NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YJR007W4.251.05E-50.45SUI2Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
YHR101C3.807.11E-50.16BIG1Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
YLR009W3.641.34E-40.08RLP24Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
YPL142C_d3.561.82E-40.09YPL142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YPR190C3.482.53E-40.11RPC82RNA polymerase III subunit C82
YJL086C_d3.363.84E-40.02YJL086C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
YDL143W3.354.10E-40.07CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YGL091C3.285.28E-40.19NBP35Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YPL010W3.090.001010.07RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YMR211W3.010.001290.02DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YGL137W2.990.001370.03SEC27Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YDL152W_d2.970.001490.02YDL152W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YOL077C2.950.001600.10BRX1Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL060W9.152.94E-20MFM1Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
YGL013C7.388.02E-14PDR1Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
YKR093W5.813.09E-9PTR2Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDL020C5.629.69E-9RPN4Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
YBL106C5.432.82E-8SRO77Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
YHL031C5.403.37E-8GOS1v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YOL058W5.276.98E-8ARG1Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YPL203W4.347.19E-6TPK2cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase
YBR194W4.279.81E-6AIM4Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
YNL154C4.221.21E-5YCK2Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
YOL118C_d4.042.67E-5YOL118C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR257C3.865.56E-5MTM1Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YEL059C-A3.855.83E-5SOM1Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
YDR529C3.778.27E-5QCR7Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YKL124W3.721.01E-4SSH4Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases

GO enrichment analysis for SGTC_1307
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1831.92E-45SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.0864198PDR1
0.1817.01E-45SGTC_12430416-0003 5.7 μMChemDiv (Drug-like library)21419770.555556PDR1
0.1797.65E-44SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.0581395PDR1
0.1554.37E-33SGTC_295k015-0027 31.0 μMChemDiv (Drug-like library)38874240.0769231PDR1
0.1511.66E-31SGTC_12770873-0036 22.0 μMChemDiv (Drug-like library)59657350.147541PDR1
0.1478.59E-30SGTC_32419133421 49.5 μMChembridge (Drug-like library)170182210.0617284PDR1
0.1461.17E-29SGTC_2508celastrol 40.5 μMMicrosource (Natural product library)1227240.103896PDR1
0.1351.62E-25SGTC_1139k015-0024 46.9 μMChemDiv (Drug-like library)27666520.0625PDR1
0.1262.75E-22SGTC_30259087895 49.5 μMChembridge (Drug-like library)171736410.0526316PDR1
0.1254.81E-22SGTC_489paxilline 115.0 μMICCB bioactive library1050080.0952381PDR1
0.1232.21E-21SGTC_250brefeldin a 552.2 μMICCB bioactive library64361870.0909091PDR1
0.1171.42E-19SGTC_26682',4'-dihydroxychalcone 15.1 μMTimTec (Pure natural product library)53572180.153846
0.1163.28E-19SGTC_32799140807 49.5 μMChembridge (Drug-like library)455957180.0727273
0.1164.10E-19SGTC_683panaxydol 45.0 μMMiscellaneous52832800.0615385sphingolipid biosynthesis & PDR1
0.1157.90E-19SGTC_1563474-0145 5.6 μMChemDiv (Drug-like library)22654710.111111endomembrane recycling

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_12440416-001552.5 μM0.61290396201ChemDiv (Drug-like library)254.323624.31922ERG2
SGTC_9571187-156114.1 μM0.5714291538454ChemDiv (Drug-like library)252.35085.01711
SGTC_12430416-00035.65 μM0.5555562141977ChemDiv (Drug-like library)286.795865.68111PDR1
SGTC_8530419-030621 μM0.52381762713ChemDiv (Drug-like library)268.35024.54512
SGTC_6491123-0311367 μM0.346939693629ChemDiv (Drug-like library)241.28513.51613endomembrane recycling
SGTC_7064262-005746.9 μM0.340909883298ChemDiv (Drug-like library)338.48644.71903fatty acid desaturase (OLE1)
SGTC_15956-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin67.5 μM0.333333688788TimTec (Pure natural product library)296.317243.91514
SGTC_26092,3,4-trihydroxy-4'-ethoxybenzophenone70 μM0.3333336708739Microsource (Natural product library)274.268662.8435redox potentiating
SGTC_8124251-0442148 μM0.3191495723007ChemDiv (Drug-like library)205.2532.42713
SGTC_25272',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone63.64 μM0.3137266728940Microsource (Natural product library)288.295243.06625