1222-0010

6-octoxypyridine-3-carboxylic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1314
Screen concentration 41.1 μM
Source ChemDiv (Drug-like library)
PubChem CID 3526027
SMILES CCCCCCCCOC1=NC=C(C=C1)C(=O)O
Standardized SMILES CCCCCCCCOc1ccc(cn1)C(=O)O
Molecular weight 251.3214
ALogP 3.99
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 13.72
% growth inhibition (Hom. pool) 10.8


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3526027
Download HIP data (tab-delimited text)  (excel)
Gene:ERG1(YGR175C)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.07||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:LCB2(YDR062W)|FD-Score:3.45|P-value:2.78E-4|Clearance:0.01||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:MAS1(YLR163C)|FD-Score:-3.8|P-value:7.24E-5|Clearance:0||SGD DESC:Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NAM9(YNL137C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.17||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:RPL3(YOR063W)|FD-Score:4.01|P-value:3.03E-5|Clearance:0.41||SGD DESC:Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus Gene:RRP36(YOR287C)|FD-Score:-3.39|P-value:3.45E-4|Clearance:0||SGD DESC:Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit Gene:SEC1(YDR164C)|FD-Score:3.53|P-value:2.06E-4|Clearance:0.08||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SPC29(YPL124W)|FD-Score:3.27|P-value:5.42E-4|Clearance:0.07||SGD DESC:Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication Gene:SUI2(YJR007W)|FD-Score:-3.51|P-value:2.27E-4|Clearance:0||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:VRG4(YGL225W)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.17||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:ERG1(YGR175C)|FD-Score:3.6|P-value:1.60E-4|Clearance:0.07||SGD DESC:Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Gene:LCB2(YDR062W)|FD-Score:3.45|P-value:2.78E-4|Clearance:0.01||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:MAS1(YLR163C)|FD-Score:-3.8|P-value:7.24E-5|Clearance:0||SGD DESC:Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:NAM9(YNL137C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.17||SGD DESC:Mitochondrial ribosomal component of the small subunit Gene:RPL3(YOR063W)|FD-Score:4.01|P-value:3.03E-5|Clearance:0.41||SGD DESC:Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus Gene:RRP36(YOR287C)|FD-Score:-3.39|P-value:3.45E-4|Clearance:0||SGD DESC:Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit Gene:SEC1(YDR164C)|FD-Score:3.53|P-value:2.06E-4|Clearance:0.08||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SPC29(YPL124W)|FD-Score:3.27|P-value:5.42E-4|Clearance:0.07||SGD DESC:Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication Gene:SUI2(YJR007W)|FD-Score:-3.51|P-value:2.27E-4|Clearance:0||SGD DESC:Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress Gene:VRG4(YGL225W)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.17||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3526027
Download HOP data (tab-delimited text)  (excel)
Gene:AMD1(YML035C)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ARG2(YJL071W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p Gene:ATG15(YCR068W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:ATG16(YMR159C)|FD-Score:3.85|P-value:5.93E-5||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:BNR1(YIL159W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:BRP1(YGL007W_d)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD32(YGR262C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CBP2(YHL038C)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Gene:CCE1(YKL011C)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA Gene:CDC73(YLR418C)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:DIA3(YDL024C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DYN3(YMR299C)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration Gene:ECM31(YBR176W)|FD-Score:-3.82|P-value:6.59E-5||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:EMI1(YDR512C)|FD-Score:-3.73|P-value:9.55E-5||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:ENV7(YPL236C)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) Gene:FET4(YMR319C)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FUR4(YBR021W)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:HES1(YOR237W)|FD-Score:-3.28|P-value:5.14E-4||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HST2(YPL015C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:HTD2(YHR067W)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology Gene:LCB3(YJL134W)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:LEM3(YNL323W)|FD-Score:3.91|P-value:4.68E-5||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MLH2(YLR035C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p Gene:MMM1(YLL006W)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MMS1(YPR164W)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay Gene:MRP49(YKL167C)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:PAI3(YMR174C)|FD-Score:-4.31|P-value:8.13E-6||SGD DESC:Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact Gene:PAU23(YLR037C)|FD-Score:4.27|P-value:9.85E-6||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PAU7(YAR020C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PAU8(YAL068C)|FD-Score:-3.88|P-value:5.21E-5||SGD DESC:Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions Gene:PMD1(YER132C)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions Gene:PTR2(YKR093W)|FD-Score:3.94|P-value:4.01E-5||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:REG1(YDR028C)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:RLM1(YPL089C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-5.67|P-value:7.07E-9||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SAK1(YER129W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SNT309(YPR101W)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:STE50(YCL032W)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:SUC2(YIL162W)|FD-Score:4.65|P-value:1.65E-6||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:TOS4(YLR183C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:TPM2(YIL138C)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TRK1(YJL129C)|FD-Score:-3.96|P-value:3.81E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:URA10(YMR271C)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication Gene:VMS1(YDR049W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans Gene:YBR027C(YBR027C_d)|FD-Score:5.76|P-value:4.12E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL034C(YGL034C_d)|FD-Score:-3.9|P-value:4.76E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR142W(YJR142W_p)|FD-Score:4.5|P-value:3.34E-6||SGD DESC:Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member Gene:YKL162C-A(YKL162C-A_d)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKR078W(YKR078W)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YLR177W(YLR177W_p)|FD-Score:4.71|P-value:1.22E-6||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR285C-A(YLR285C-A_p)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YNL097C-B(YNL097C-B_p)|FD-Score:3.8|P-value:7.20E-5||SGD DESC:Putative protein of unknown function Gene:YNL226W(YNL226W_d)|FD-Score:6.42|P-value:7.01E-11||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YNL319W(YNL319W_d)|FD-Score:-3.22|P-value:6.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Gene:YOL037C(YOL037C_d)|FD-Score:3.82|P-value:6.57E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Gene:YOR277C(YOR277C_d)|FD-Score:5.93|P-value:1.53E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPR064W(YPR064W_d)|FD-Score:-3.62|P-value:1.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YRO2(YBR054W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication Gene:AMD1(YML035C)|FD-Score:-3.64|P-value:1.38E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ARG2(YJL071W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p Gene:ATG15(YCR068W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:ATG16(YMR159C)|FD-Score:3.85|P-value:5.93E-5||SGD DESC:Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:BNR1(YIL159W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:BRP1(YGL007W_d)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD32(YGR262C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CBP2(YHL038C)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Gene:CCE1(YKL011C)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA Gene:CDC73(YLR418C)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:DIA3(YDL024C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth Gene:DYN3(YMR299C)|FD-Score:3.37|P-value:3.71E-4||SGD DESC:Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration Gene:ECM31(YBR176W)|FD-Score:-3.82|P-value:6.59E-5||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:EMI1(YDR512C)|FD-Score:-3.73|P-value:9.55E-5||SGD DESC:Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs Gene:ENV7(YPL236C)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) Gene:FET4(YMR319C)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FUR4(YBR021W)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:HES1(YOR237W)|FD-Score:-3.28|P-value:5.14E-4||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HST2(YPL015C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:HTD2(YHR067W)|FD-Score:-3.1|P-value:9.79E-4||SGD DESC:Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology Gene:LCB3(YJL134W)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:LEM3(YNL323W)|FD-Score:3.91|P-value:4.68E-5||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MLH2(YLR035C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p Gene:MMM1(YLL006W)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MMS1(YPR164W)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay Gene:MRP49(YKL167C)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:PAI3(YMR174C)|FD-Score:-4.31|P-value:8.13E-6||SGD DESC:Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact Gene:PAU23(YLR037C)|FD-Score:4.27|P-value:9.85E-6||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PAU7(YAR020C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PAU8(YAL068C)|FD-Score:-3.88|P-value:5.21E-5||SGD DESC:Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions Gene:PMD1(YER132C)|FD-Score:-3.97|P-value:3.55E-5||SGD DESC:Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions Gene:PTR2(YKR093W)|FD-Score:3.94|P-value:4.01E-5||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:REG1(YDR028C)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:RLM1(YPL089C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-5.67|P-value:7.07E-9||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SAK1(YER129W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SNT309(YPR101W)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:STE50(YCL032W)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction Gene:SUC2(YIL162W)|FD-Score:4.65|P-value:1.65E-6||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:TOS4(YLR183C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:TPM2(YIL138C)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TRK1(YJL129C)|FD-Score:-3.96|P-value:3.81E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication Gene:URA10(YMR271C)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication Gene:VMS1(YDR049W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans Gene:YBR027C(YBR027C_d)|FD-Score:5.76|P-value:4.12E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGL034C(YGL034C_d)|FD-Score:-3.9|P-value:4.76E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR142W(YJR142W_p)|FD-Score:4.5|P-value:3.34E-6||SGD DESC:Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member Gene:YKL162C-A(YKL162C-A_d)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKR078W(YKR078W)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YLR177W(YLR177W_p)|FD-Score:4.71|P-value:1.22E-6||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR285C-A(YLR285C-A_p)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YNL097C-B(YNL097C-B_p)|FD-Score:3.8|P-value:7.20E-5||SGD DESC:Putative protein of unknown function Gene:YNL226W(YNL226W_d)|FD-Score:6.42|P-value:7.01E-11||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YNL319W(YNL319W_d)|FD-Score:-3.22|P-value:6.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Gene:YOL037C(YOL037C_d)|FD-Score:3.82|P-value:6.57E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Gene:YOR277C(YOR277C_d)|FD-Score:5.93|P-value:1.53E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPR064W(YPR064W_d)|FD-Score:-3.62|P-value:1.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YRO2(YBR054W)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR063W4.013.03E-50.41RPL3Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
YGR175C3.601.60E-40.07ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YDR164C3.532.06E-40.08SEC1Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
YDR062W3.452.78E-40.01LCB2Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YNL137C3.442.92E-40.17NAM9Mitochondrial ribosomal component of the small subunit
YPL124W3.275.42E-40.07SPC29Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
YGL225W3.206.97E-40.17VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YDR045C3.020.001260.06RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YKR083C2.960.001530.12DAD2Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YPR019W2.840.002220.02MCM4Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
YPR178W2.820.002370.01PRP4Splicing factor, component of the U4/U6-U5 snRNP complex
YLR229C2.810.002440.06CDC42Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YOR020C2.750.002970.06HSP10Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YLR272C2.690.003600.06YCS4Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
YOR218C_d2.620.004340.01YOR218C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL226W_d6.427.01E-11YNL226W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
YOR277C_d5.931.53E-9YOR277C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YBR027C_d5.764.12E-9YBR027C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR177W_p4.711.22E-6YLR177W_pPutative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
YIL162W4.651.65E-6SUC2Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YJR142W_p4.503.34E-6YJR142W_pPutative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
YPR101W4.454.29E-6SNT309Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YLR037C4.279.85E-6PAU23Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
YKR093W3.944.01E-5PTR2Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YNL323W3.914.68E-5LEM3Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YLL006W3.894.95E-5MMM1ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YMR159C3.855.93E-5ATG16Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YOL037C_d3.826.57E-5YOL037C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
YNL097C-B_p3.807.20E-5YNL097C-B_pPutative protein of unknown function
YAR020C3.671.19E-4PAU7Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme

GO enrichment analysis for SGTC_1314
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0921.23E-12SGTC_23519026858 72.3 μMChembridge (Fragment library)14093000.0806452RNA processing & uracil transport
0.0841.21E-10SGTC_13051181-0477 144.0 μMChemDiv (Drug-like library)62520860.123077
0.0831.57E-10SGTC_23939031399 185.9 μMChembridge (Fragment library)15266230.0983607RNA processing & uracil transport
0.0814.28E-10SGTC_22216807166 181.1 μMChembridge (Fragment library)6749250.0923077
0.0764.21E-9SGTC_13181280-3875 124.0 μMChemDiv (Drug-like library)3732450.0612245
0.0764.45E-9SGTC_8910929-0073 133.0 μMChemDiv (Drug-like library)56036320.0606061
0.0741.53E-8SGTC_1950st077106 7.2 μMTimTec (Natural product derivative library)138318640.0952381RNA processing & uracil transport
0.0731.58E-8SGTC_1814st052110 31.5 μMTimTec (Natural product derivative library)6741630.125RNA processing & uracil transport
0.0731.82E-8SGTC_20825219693 150.0 μMChembridge (Fragment library)28346490.0625RNA processing & uracil transport
0.0722.99E-8SGTC_398bronopol 33.3 μMMiscellaneous24500.0612245RNA processing & uracil transport
0.0723.69E-8SGTC_12961068-0102 11.9 μMChemDiv (Drug-like library)7670530.163934
0.0707.27E-8SGTC_1817st052116 64.4 μMTimTec (Natural product derivative library)43613980.136364RNA processing & uracil transport
0.0681.97E-7SGTC_9231900-2434 73.3 μMChemDiv (Drug-like library)59105700.0657895RNA processing & uracil transport
0.0663.90E-7SGTC_397arbidol 50.0 μMMiscellaneous1314100.135802cell wall
0.0631.05E-6SGTC_32019113999 49.5 μMChembridge (Drug-like library)166492240.130435

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1290088-0017176.64 μM0.489362182446ChemDiv (Drug-like library)278.343483.63914
SGTC_2248tofa1.1 μM0.478261115175Miscellaneous324.454986.85314sphingolipid biosynthesis & PDR1
SGTC_2416tofa880 nM0.478261115175Miscellaneous324.454986.85314sphingolipid biosynthesis & PDR1
SGTC_980074-0023107.66 μM0.4565223563821ChemDiv (Drug-like library)278.343484.63114Golgi
SGTC_820054-0107293.76 μM0.423104697ChemDiv (Drug-like library)340.412866.11514
SGTC_269exalamide29 μM0.3958333316Miscellaneous221.295463.05612ergosterol biosynthesis
SGTC_1121fusaric acid630.51 nM0.3829793442TimTec (Natural product library)179.215722.59213
SGTC_2680butyl paraben22.24 μM0.3695657184Microsource (Natural product library)194.227062.77213amide catabolism
SGTC_790052-000794.09 μM0.3673472801472ChemDiv (Drug-like library)276.370664.63813
SGTC_9581222-000733 μM0.367312461ChemDiv (Drug-like library)246.344685.14112
SGTC_9591222-0044107 μM0.346083612ChemDiv (Drug-like library)232.31814.68512