1237-0019

8-methylindeno[1,2-b]quinoxalin-11-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1315
Screen concentration 3.7 μM
Source ChemDiv (Drug-like library)
PubChem CID 825140
SMILES CC1=CC2=C(C=C1)N=C3C4=CC=CC=C4C(=O)C3=N2
Standardized SMILES Cc1ccc2nc3c4ccccc4C(=O)c3nc2c1
Molecular weight 246.2634
ALogP 3.73
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11
% growth inhibition (Hom. pool) 4.05


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 825140
Download HIP data (tab-delimited text)  (excel)
Gene:DBP2(YNL112W)|FD-Score:4.48|P-value:3.66E-6|Clearance:0.07||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:FMN1(YDR236C)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.01||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:GLE1(YDL207W)|FD-Score:3.56|P-value:1.88E-4|Clearance:0.12||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:HEM12(YDR047W)|FD-Score:4.07|P-value:2.36E-5|Clearance:0.08||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:HEM3(YDL205C)|FD-Score:3.44|P-value:2.94E-4|Clearance:0.02||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:LSG1(YGL099W)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.16||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM1(YMR043W)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.06||SGD DESC:Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes Gene:NAF1(YNL124W)|FD-Score:3.99|P-value:3.37E-5|Clearance:0.43||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NMD3(YHR170W)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.11||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PKC1(YBL105C)|FD-Score:4.07|P-value:2.34E-5|Clearance:0||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE3(YJL001W)|FD-Score:-3.16|P-value:7.85E-4|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:RIM2(YBR192W)|FD-Score:7.03|P-value:1.06E-12|Clearance:2.54||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPS20(YHL015W)|FD-Score:-3.26|P-value:5.57E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 Gene:RSP5(YER125W)|FD-Score:4.42|P-value:5.04E-6|Clearance:0.18||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SFT1(YKL006C-A)|FD-Score:3.3|P-value:4.91E-4|Clearance:0.16||SGD DESC:Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment Gene:DBP2(YNL112W)|FD-Score:4.48|P-value:3.66E-6|Clearance:0.07||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:FMN1(YDR236C)|FD-Score:3.31|P-value:4.66E-4|Clearance:0.01||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:GLE1(YDL207W)|FD-Score:3.56|P-value:1.88E-4|Clearance:0.12||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:HEM12(YDR047W)|FD-Score:4.07|P-value:2.36E-5|Clearance:0.08||SGD DESC:Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda Gene:HEM3(YDL205C)|FD-Score:3.44|P-value:2.94E-4|Clearance:0.02||SGD DESC:Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme Gene:LSG1(YGL099W)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.16||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM1(YMR043W)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.06||SGD DESC:Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes Gene:NAF1(YNL124W)|FD-Score:3.99|P-value:3.37E-5|Clearance:0.43||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NMD3(YHR170W)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.11||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PKC1(YBL105C)|FD-Score:4.07|P-value:2.34E-5|Clearance:0||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRE3(YJL001W)|FD-Score:-3.16|P-value:7.85E-4|Clearance:0||SGD DESC:Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides Gene:RIM2(YBR192W)|FD-Score:7.03|P-value:1.06E-12|Clearance:2.54||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPS20(YHL015W)|FD-Score:-3.26|P-value:5.57E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 Gene:RSP5(YER125W)|FD-Score:4.42|P-value:5.04E-6|Clearance:0.18||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SFT1(YKL006C-A)|FD-Score:3.3|P-value:4.91E-4|Clearance:0.16||SGD DESC:Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 825140
Download HOP data (tab-delimited text)  (excel)
Gene:ACO1(YLR304C)|FD-Score:4.1|P-value:2.04E-5||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ADE6(YGR061C)|FD-Score:3.11|P-value:9.34E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ARX1(YDR101C)|FD-Score:-3.77|P-value:8.32E-5||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex Gene:BNA6(YFR047C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:CKA2(YOR061W)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching Gene:CKI1(YLR133W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CSM1(YCR086W)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation Gene:CSR2(YPR030W)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication Gene:CTS2(YDR371W_p)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect Gene:DHH1(YDL160C)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:EBS1(YDR206W)|FD-Score:-4.36|P-value:6.40E-6||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:GAS4(YOL132W)|FD-Score:-3.95|P-value:3.85E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GEA1(YJR031C)|FD-Score:5.15|P-value:1.31E-7||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GTT3(YEL017W)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:IES1(YFL013C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:IFA38(YBR159W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides Gene:IPT1(YDR072C)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin Gene:IRS4(YKR019C)|FD-Score:-3.1|P-value:9.83E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LAG1(YHL003C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress Gene:LEU4(YNL104C)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication Gene:MMM1(YLL006W)|FD-Score:4.58|P-value:2.32E-6||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MON1(YGL124C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MPP6(YNR024W)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes Gene:PHD1(YKL043W)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication Gene:PUS2(YGL063W)|FD-Score:6.13|P-value:4.31E-10||SGD DESC:Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification Gene:RIM8(YGL045W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL40B(YKR094C)|FD-Score:-3.32|P-value:4.45E-4||SGD DESC:Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication Gene:RUP1(YOR138C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SIF2(YBR103W)|FD-Score:4.45|P-value:4.37E-6||SGD DESC:WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus Gene:SMP1(YBR182C)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication Gene:TMA7(YLR262C-A)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress Gene:TPM2(YIL138C)|FD-Score:5.89|P-value:1.92E-9||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TUF1(YOR187W)|FD-Score:-4.1|P-value:2.09E-5||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:WHI3(YNL197C)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication Gene:WWM1(YFL010C)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YBL071C-B(YBL071C-B_p)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR442W(YDR442W_d)|FD-Score:-3.17|P-value:7.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER188W(YER188W_d)|FD-Score:-4.35|P-value:6.87E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YHR140W(YHR140W_p)|FD-Score:5.45|P-value:2.46E-8||SGD DESC:Putative integral membrane protein of unknown function Gene:YJR020W(YJR020W_d)|FD-Score:3.8|P-value:7.10E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YLR173W(YLR173W_p)|FD-Score:-3.1|P-value:9.77E-4||SGD DESC:Putative protein of unknown function Gene:YMR155W(YMR155W_p)|FD-Score:3.29|P-value:5.03E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR254C(YMR254C_d)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR040W(YNR040W_p)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR292C(YOR292C_p)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene Gene:YPL014W(YPL014W_p)|FD-Score:-3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YPR015C(YPR015C_p)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:YPT6(YLR262C)|FD-Score:4.71|P-value:1.21E-6||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YRM1(YOR172W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:ACO1(YLR304C)|FD-Score:4.1|P-value:2.04E-5||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ADE6(YGR061C)|FD-Score:3.11|P-value:9.34E-4||SGD DESC:Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:ARX1(YDR101C)|FD-Score:-3.77|P-value:8.32E-5||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex Gene:BNA6(YFR047C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:CKA2(YOR061W)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching Gene:CKI1(YLR133W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CSM1(YCR086W)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation Gene:CSR2(YPR030W)|FD-Score:-3.75|P-value:9.02E-5||SGD DESC:Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication Gene:CTS2(YDR371W_p)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect Gene:DHH1(YDL160C)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:EBS1(YDR206W)|FD-Score:-4.36|P-value:6.40E-6||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:GAS4(YOL132W)|FD-Score:-3.95|P-value:3.85E-5||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GEA1(YJR031C)|FD-Score:5.15|P-value:1.31E-7||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GTT3(YEL017W)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery Gene:IES1(YFL013C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:IFA38(YBR159W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides Gene:IPT1(YDR072C)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin Gene:IRS4(YKR019C)|FD-Score:-3.1|P-value:9.83E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:LAG1(YHL003C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress Gene:LEU4(YNL104C)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication Gene:MMM1(YLL006W)|FD-Score:4.58|P-value:2.32E-6||SGD DESC:ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MON1(YGL124C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MPP6(YNR024W)|FD-Score:3.4|P-value:3.42E-4||SGD DESC:Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes Gene:PHD1(YKL043W)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication Gene:PUS2(YGL063W)|FD-Score:6.13|P-value:4.31E-10||SGD DESC:Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification Gene:RIM8(YGL045W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL40B(YKR094C)|FD-Score:-3.32|P-value:4.45E-4||SGD DESC:Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication Gene:RUP1(YOR138C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SIF2(YBR103W)|FD-Score:4.45|P-value:4.37E-6||SGD DESC:WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus Gene:SMP1(YBR182C)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication Gene:TMA7(YLR262C-A)|FD-Score:3.14|P-value:8.48E-4||SGD DESC:Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress Gene:TPM2(YIL138C)|FD-Score:5.89|P-value:1.92E-9||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TUF1(YOR187W)|FD-Score:-4.1|P-value:2.09E-5||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:WHI3(YNL197C)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication Gene:WWM1(YFL010C)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YBL071C-B(YBL071C-B_p)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR442W(YDR442W_d)|FD-Score:-3.17|P-value:7.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER188W(YER188W_d)|FD-Score:-4.35|P-value:6.87E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YHR140W(YHR140W_p)|FD-Score:5.45|P-value:2.46E-8||SGD DESC:Putative integral membrane protein of unknown function Gene:YJR020W(YJR020W_d)|FD-Score:3.8|P-value:7.10E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL106C-A(YKL106C-A_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi Gene:YLR173W(YLR173W_p)|FD-Score:-3.1|P-value:9.77E-4||SGD DESC:Putative protein of unknown function Gene:YMR155W(YMR155W_p)|FD-Score:3.29|P-value:5.03E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR254C(YMR254C_d)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNR040W(YNR040W_p)|FD-Score:3.28|P-value:5.16E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR292C(YOR292C_p)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene Gene:YPL014W(YPL014W_p)|FD-Score:-3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YPR015C(YPR015C_p)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:YPT6(YLR262C)|FD-Score:4.71|P-value:1.21E-6||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YRM1(YOR172W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR192W7.031.06E-122.54RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YNL112W4.483.66E-60.07DBP2ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
YER125W4.425.04E-60.18RSP5E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
YGL099W4.231.16E-50.16LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YBL105C4.072.34E-50.00PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YDR047W4.072.36E-50.08HEM12Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YNL124W3.993.37E-50.43NAF1RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YDL207W3.561.88E-40.12GLE1Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
YDL205C3.442.94E-40.02HEM3Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
YHR170W3.423.12E-40.11NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YDR236C3.314.66E-40.01FMN1Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
YKL006C-A3.304.91E-40.16SFT1Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
YMR043W3.148.53E-40.06MCM1Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YDR339C3.080.001046.66E-4FCF1Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
YDR082W3.080.001040.07STN1Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL063W6.134.31E-10PUS2Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
YIL138C5.891.92E-9TPM2Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
YHR140W_p5.452.46E-8YHR140W_pPutative integral membrane protein of unknown function
YJR031C5.151.31E-7GEA1Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
YLR262C4.711.21E-6YPT6Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YLL006W4.582.32E-6MMM1ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YBR103W4.454.37E-6SIF2WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
YKL106C-A_p4.241.11E-5YKL106C-A_pPutative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
YLR304C4.102.04E-5ACO1Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YJR020W_d3.807.10E-5YJR020W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL017W3.701.06E-4GTT3Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YGL124C3.661.28E-4MON1Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
YHL003C3.512.24E-4LAG1Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
YBR159W3.502.29E-4IFA38Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YOR172W3.492.41E-4YRM1Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes

GO enrichment analysis for SGTC_1315
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1824.21E-45SGTC_623k072-0108 16.9 μMChemDiv (Drug-like library)53828030.140351heme biosynthesis & mitochondrial translocase
0.1824.74E-45SGTC_1113artemisinin 1.2 μMTimTec (Natural product library)22400.0625heme biosynthesis & mitochondrial translocase
0.1454.30E-29SGTC_7301436-0052 41.2 μMChemDiv (Drug-like library)7687640.0983607mitochondrial processes
0.1323.49E-24SGTC_2519cryptotanshinone 88.0 μMMicrosource (Natural product library)1602540.123077heme biosynthesis & mitochondrial translocase
0.1316.93E-24SGTC_8420271-0008 11.1 μMChemDiv (Drug-like library)12217090.212766heme biosynthesis & mitochondrial translocase
0.1231.93E-21SGTC_10441222-0021 1.8 μMChemDiv (Drug-like library)43067030.0952381heme biosynthesis & mitochondrial translocase
0.1232.45E-21SGTC_208k072-0098 12.4 μMChemDiv (Drug-like library)59489010.107143heme biosynthesis & mitochondrial translocase
0.1171.60E-19SGTC_15526-methylflavone 10.6 μMTimTec (Pure natural product library)6890130.291667superoxide
0.1172.41E-19SGTC_1098clofazimine 15.1 μMNIH Clinical Collection27940.0958904heme biosynthesis & mitochondrial translocase
0.1166.33E-19SGTC_10258-0098 57.4 μMChemDiv (Drug-like library)67900320.0895522heme biosynthesis & mitochondrial translocase
0.1111.12E-17SGTC_6023130-1533 38.1 μMChemDiv (Drug-like library)7209410.218182
0.1111.52E-17SGTC_24755812728 15.0 μMMiscellaneous7761600.196429mitochondrial processes
0.1111.71E-17SGTC_29289011484 9.8 μMChembridge (Drug-like library)29947510.0923077heme biosynthesis & mitochondrial translocase
0.1094.29E-17SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.17241460S ribosome export
0.1095.99E-17SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.12820560S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1036k216-021533.5 μM0.666667622330ChemDiv (Drug-like library)266.681883.90803mitochondrial response to ROS
SGTC_1930st07463434.3 μM0.5684253TimTec (Natural product derivative library)245.275344.02302RNA pol III & RNase P/MRP
SGTC_2681menadione3.18 μM0.3421054055Miscellaneous172.180022.20402superoxide
SGTC_394menadione8.33 μM0.3421054055Miscellaneous172.180022.20402superoxide
SGTC_8380109-020371.4 μM0.340909759422ChemDiv (Drug-like library)208.258483.75611
SGTC_13601598-002239.8 μM0.319149761525ChemDiv (Drug-like library)248.322345.07712ERG2
SGTC_1309pyrazolanthrone13.4 μM0.3181828515ChemDiv (Drug-like library)220.226122.99412
SGTC_20405100729123 μM0.31707311840Chembridge (Fragment library)161.157381.15612
SGTC_20124023501200 μM0.3095243477460Chembridge (Fragment library)175.183961.36202
SGTC_770828-028612.52 μM0.294118745345ChemDiv (Drug-like library)264.275383.23803TSC3-RPN4
SGTC_11700310-012764.8 μM0.294118774975ChemDiv (Drug-like library)251.236862.98804