Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL063W | 6.13 | 4.31E-10 | PUS2 | Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification |
YIL138C | 5.89 | 1.92E-9 | TPM2 | Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication |
YHR140W_p | 5.45 | 2.46E-8 | YHR140W_p | Putative integral membrane protein of unknown function |
YJR031C | 5.15 | 1.31E-7 | GEA1 | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication |
YLR262C | 4.71 | 1.21E-6 | YPT6 | Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 |
YLL006W | 4.58 | 2.32E-6 | MMM1 | ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth |
YBR103W | 4.45 | 4.37E-6 | SIF2 | WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus |
YKL106C-A_p | 4.24 | 1.11E-5 | YKL106C-A_p | Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi |
YLR304C | 4.10 | 2.04E-5 | ACO1 | Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy |
YJR020W_d | 3.80 | 7.10E-5 | YJR020W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YEL017W | 3.70 | 1.06E-4 | GTT3 | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery |
YGL124C | 3.66 | 1.28E-4 | MON1 | Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate |
YHL003C | 3.51 | 2.24E-4 | LAG1 | Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress |
YBR159W | 3.50 | 2.29E-4 | IFA38 | Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides |
YOR172W | 3.49 | 2.41E-4 | YRM1 | Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes |