Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER083C | 7.04 | 9.43E-13 | GET2 | Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division |
YJL170C | 6.65 | 1.46E-11 | ASG7 | Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor |
YOL065C | 6.28 | 1.70E-10 | INP54 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins |
YDR136C_d | 6.27 | 1.79E-10 | VPS61_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect |
YPR017C | 5.65 | 8.20E-9 | DSS4 | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
YJL004C | 5.14 | 1.39E-7 | SYS1 | Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation |
YDR439W | 5.07 | 1.95E-7 | LRS4 | Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation |
YNL053W | 5.00 | 2.91E-7 | MSG5 | Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p |
YDR108W | 4.84 | 6.44E-7 | TRS85 | Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role |
YDR140W | 4.80 | 7.99E-7 | MTQ2 | S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC |
YPL198W | 4.58 | 2.32E-6 | RPL7B | Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication |
YJR125C | 4.56 | 2.59E-6 | ENT3 | Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p |
YML087C | 4.51 | 3.19E-6 | AIM33 | Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication |
YAL022C | 4.36 | 6.46E-6 | FUN26 | Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis |
YJL162C | 4.36 | 6.47E-6 | JJJ2 | Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein |