1326-2144

5-(1,4-dioxaspiro[4.5]decan-3-yl)spiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclohexane]-6-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1321
Screen concentration 215.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 3513030
SMILES C1CCC2(CC1)OCC(O2)C3C(C4C(O3)OC5(O4)CCCCC5)O
Standardized SMILES OC1C(OC2OC3(CCCCC3)OC12)C4COC5(CCCCC5)O4
Molecular weight 340.4113
ALogP 1.74
H-bond donor count 1
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.2
% growth inhibition (Hom. pool) 2.09


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3513030
Download HIP data (tab-delimited text)  (excel)
Gene:BBP1(YPL255W)|FD-Score:3.35|P-value:4.07E-4|Clearance:0.31||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:BMS1(YPL217C)|FD-Score:-3.32|P-value:4.46E-4|Clearance:0||SGD DESC:GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p Gene:CDC1(YDR182W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.09||SGD DESC:Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution Gene:CWC2(YDL209C)|FD-Score:3.81|P-value:6.84E-5|Clearance:0.33||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 Gene:ESF2(YNR054C)|FD-Score:-3.19|P-value:7.01E-4|Clearance:0||SGD DESC:Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome Gene:KAR1(YNL188W)|FD-Score:4.39|P-value:5.54E-6|Clearance:0.43||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:RRP9(YPR137W)|FD-Score:3.39|P-value:3.45E-4|Clearance:0.02||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SDA1(YGR245C)|FD-Score:3.37|P-value:3.73E-4|Clearance:0.02||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:UBC1(YDR177W)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.43||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:UTP7(YER082C)|FD-Score:4.41|P-value:5.08E-6|Clearance:0.43||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:BBP1(YPL255W)|FD-Score:3.35|P-value:4.07E-4|Clearance:0.31||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:BMS1(YPL217C)|FD-Score:-3.32|P-value:4.46E-4|Clearance:0||SGD DESC:GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p Gene:CDC1(YDR182W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.09||SGD DESC:Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution Gene:CWC2(YDL209C)|FD-Score:3.81|P-value:6.84E-5|Clearance:0.33||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 Gene:ESF2(YNR054C)|FD-Score:-3.19|P-value:7.01E-4|Clearance:0||SGD DESC:Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome Gene:KAR1(YNL188W)|FD-Score:4.39|P-value:5.54E-6|Clearance:0.43||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:RRP9(YPR137W)|FD-Score:3.39|P-value:3.45E-4|Clearance:0.02||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SDA1(YGR245C)|FD-Score:3.37|P-value:3.73E-4|Clearance:0.02||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:UBC1(YDR177W)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.43||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:UTP7(YER082C)|FD-Score:4.41|P-value:5.08E-6|Clearance:0.43||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3513030
Download HOP data (tab-delimited text)  (excel)
Gene:AIM7(YDR063W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss Gene:CAP2(YIL034C)|FD-Score:4.62|P-value:1.89E-6||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:DSE4(YNR067C)|FD-Score:-3.73|P-value:9.56E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:EFG1(YGR271C-A)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FES1(YBR101C)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:GIT1(YCR098C)|FD-Score:6.1|P-value:5.25E-10||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GLN3(YER040W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:GTT1(YIR038C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p Gene:HAC1(YFL031W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:HCR1(YLR192C)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Gene:HXT8(YJL214W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:IMG2(YCR071C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IXR1(YKL032C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:MDM34(YGL219C)|FD-Score:5.24|P-value:7.87E-8||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MET32(YDR253C)|FD-Score:3.9|P-value:4.81E-5||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MFM1(YPL060W)|FD-Score:4.38|P-value:5.95E-6||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MON1(YGL124C)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MRP21(YBL090W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MRPS17(YMR188C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NHP6B(YBR089C-A)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication Gene:PRR2(YDL214C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance Gene:REI1(YBR267W)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RRD2(YPL152W)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress Gene:RRF1(YHR038W)|FD-Score:4.52|P-value:3.06E-6||SGD DESC:Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria Gene:RRT12(YCR045C)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:RTG1(YOL067C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SCD6(YPR129W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SHB17(YKR043C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SPS100(YHR139C)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SSK1(YLR006C)|FD-Score:-3.68|P-value:1.19E-4||SGD DESC:Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate Gene:STL1(YDR536W)|FD-Score:-3.19|P-value:7.00E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TMA46(YOR091W)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:UTR2(YEL040W)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck Gene:VID30(YGL227W)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm Gene:VPS62(YGR141W)|FD-Score:-4.09|P-value:2.19E-5||SGD DESC:Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins Gene:VTA1(YLR181C)|FD-Score:3.11|P-value:9.22E-4||SGD DESC:Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain Gene:YBR137W(YBR137W)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene Gene:YCR051W(YCR051W_p)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDR524W-C(YDR524W-C_p)|FD-Score:-3.31|P-value:4.66E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YER186C(YER186C_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function Gene:YHR177W(YHR177W_p)|FD-Score:3.29|P-value:4.92E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:YKL033W-A(YKL033W-A_p)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Putative protein of unknown function; similar to uncharacterized proteins from other fungi Gene:YNL203C(YNL203C_d)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOP1(YPR028W)|FD-Score:4.29|P-value:8.97E-6||SGD DESC:Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress Gene:YPL102C(YPL102C_d)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Gene:AIM7(YDR063W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss Gene:CAP2(YIL034C)|FD-Score:4.62|P-value:1.89E-6||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:DSE4(YNR067C)|FD-Score:-3.73|P-value:9.56E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:EFG1(YGR271C-A)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FES1(YBR101C)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:GIT1(YCR098C)|FD-Score:6.1|P-value:5.25E-10||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GLN3(YER040W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:GTT1(YIR038C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p Gene:HAC1(YFL031W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:HCR1(YLR192C)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Gene:HXT8(YJL214W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:IMG2(YCR071C)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:IXR1(YKL032C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:MDM34(YGL219C)|FD-Score:5.24|P-value:7.87E-8||SGD DESC:Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth Gene:MET32(YDR253C)|FD-Score:3.9|P-value:4.81E-5||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MFM1(YPL060W)|FD-Score:4.38|P-value:5.95E-6||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:MON1(YGL124C)|FD-Score:4.05|P-value:2.59E-5||SGD DESC:Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate Gene:MRP21(YBL090W)|FD-Score:3.87|P-value:5.49E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences Gene:MRPS17(YMR188C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NHP6B(YBR089C-A)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication Gene:PRR2(YDL214C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance Gene:REI1(YBR267W)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RRD2(YPL152W)|FD-Score:-3.33|P-value:4.36E-4||SGD DESC:Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress Gene:RRF1(YHR038W)|FD-Score:4.52|P-value:3.06E-6||SGD DESC:Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria Gene:RRT12(YCR045C)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:RTG1(YOL067C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SCD6(YPR129W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SHB17(YKR043C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SPS100(YHR139C)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:SSK1(YLR006C)|FD-Score:-3.68|P-value:1.19E-4||SGD DESC:Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate Gene:STL1(YDR536W)|FD-Score:-3.19|P-value:7.00E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TMA46(YOR091W)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:UTR2(YEL040W)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck Gene:VID30(YGL227W)|FD-Score:-3.23|P-value:6.10E-4||SGD DESC:Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm Gene:VPS62(YGR141W)|FD-Score:-4.09|P-value:2.19E-5||SGD DESC:Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins Gene:VTA1(YLR181C)|FD-Score:3.11|P-value:9.22E-4||SGD DESC:Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain Gene:YBR137W(YBR137W)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene Gene:YCR051W(YCR051W_p)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDR524W-C(YDR524W-C_p)|FD-Score:-3.31|P-value:4.66E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YER186C(YER186C_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function Gene:YHR177W(YHR177W_p)|FD-Score:3.29|P-value:4.92E-4||SGD DESC:Putative protein of unknown function; overexpression causes a cell cycle delay or arrest Gene:YKL033W-A(YKL033W-A_p)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Putative protein of unknown function; similar to uncharacterized proteins from other fungi Gene:YNL203C(YNL203C_d)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOP1(YPR028W)|FD-Score:4.29|P-value:8.97E-6||SGD DESC:Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress Gene:YPL102C(YPL102C_d)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER082C4.415.08E-60.42UTP7Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL188W4.395.54E-60.42KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YDR177W4.241.12E-50.42UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YDL209C3.816.84E-50.33CWC2Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
YDR182W3.492.46E-40.09CDC1Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
YPR137W3.393.45E-40.02RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YGR245C3.373.73E-40.02SDA1Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YPL255W3.354.07E-40.31BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YPL209C3.030.001200.15IPL1Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
YIL118W2.890.001950.06RHO3Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YBR110W2.830.002330.02ALG1Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
YDL217C2.810.002470.05TIM22Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
YBL084C2.760.002911.55E-4CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YOR075W2.760.002910.04UFE1t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
YBR087W2.720.003270.06RFC5Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR098C6.105.25E-10GIT1Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YGL219C5.247.87E-8MDM34Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YIL034C4.621.89E-6CAP2Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
YHR038W4.523.06E-6RRF1Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YPL060W4.385.95E-6MFM1Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
YPR028W4.298.97E-6YOP1Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
YDL214C4.251.08E-5PRR2Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
YCR045C4.201.34E-5RRT12Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
YGL124C4.052.59E-5MON1Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
YDR253C3.904.81E-5MET32Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
YBL090W3.875.49E-5MRP21Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YBR101C3.855.81E-5FES1Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
YNL203C_d3.691.13E-4YNL203C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR188C3.651.32E-4MRPS17Mitochondrial ribosomal protein of the small subunit
YIR038C3.651.33E-4GTT1ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p

GO enrichment analysis for SGTC_1321
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0765.29E-9SGTC_1841st054148 70.0 μMTimTec (Natural product derivative library)6754420.0133333
0.0682.01E-7SGTC_1938st074717 56.4 μMTimTec (Natural product derivative library)172509790.0675676
0.0641.05E-6SGTC_9093448-9333 149.0 μMChemDiv (Drug-like library)33440740.0694444
0.0603.96E-6SGTC_9923909-8734 162.0 μMChemDiv (Drug-like library)4288319NA
0.0552.12E-5SGTC_28949048625 32.5 μMChembridge (Drug-like library)40928610.0597015
0.0552.58E-5SGTC_9061165-0455 526.0 μMChemDiv (Drug-like library)3252859NA
0.0526.66E-5SGTC_8890919-1524 82.7 μMChemDiv (Drug-like library)39054520.0136986
0.0518.17E-5SGTC_7891309-1135 70.6 μMChemDiv (Drug-like library)3092424NAERG2
0.0501.40E-4SGTC_6751309-0189 238.0 μMChemDiv (Drug-like library)42465300.0246914
0.0491.60E-4SGTC_10134112-3890 241.0 μMChemDiv (Drug-like library)7051710.038961TSC3-RPN4
0.0482.49E-4SGTC_21545570129 200.0 μMChembridge (Fragment library)673366NA
0.0472.80E-4SGTC_9953931-2021 34.6 μMChemDiv (Drug-like library)7301430.025974RPP1 & pyrimidine depletion
0.0472.96E-4SGTC_13621611-0397 101.0 μMChemDiv (Drug-like library)27816NA
0.0464.41E-4SGTC_8151582-0027 36.9 μMChemDiv (Drug-like library)31282060.0133333
0.0455.54E-4SGTC_2643anethole 100.0 μMMicrosource (Natural product library)637563NA

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13903413-2614145 μM0.3260873421432ChemDiv (Drug-like library)309.48674.59303fatty acid desaturase (OLE1)
SGTC_14173966-032790.4 μM0.245902651118ChemDiv (Drug-like library)316.35171.32314
SGTC_22107115885190.39 μM0.162927039Chembridge (Fragment library)227.687362.28523cell wall signaling
SGTC_9571187-156114.1 μM0.141538454ChemDiv (Drug-like library)252.35085.01711
SGTC_12430416-00035.65 μM0.1372552141977ChemDiv (Drug-like library)286.795865.68111PDR1
SGTC_1690st02350241.2 μM0.13333324207482TimTec (Natural product derivative library)485.721866.56126calcium & mitochondrial duress
SGTC_12440416-001552.5 μM0.13043596201ChemDiv (Drug-like library)254.323624.31922ERG2
SGTC_25422-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene100 μM0.1272735024745Microsource (Natural product library)238.365742.49912
SGTC_266formosanin C406 nM0.1238173597Miscellaneous1015.184780.311020sphingolipid biosynthesis & PDR1
SGTC_13071187-159912.2 μM0.1228071538471ChemDiv (Drug-like library)296.403365.3512PDR1