Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL025C | 7.51 | 2.88E-14 | SSN8 | Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance |
YCR092C | 5.58 | 1.18E-8 | MSH3 | Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability |
YML067C | 4.99 | 3.00E-7 | ERV41 | Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein |
YOR089C | 4.87 | 5.49E-7 | VPS21 | Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication |
YGL224C | 4.83 | 6.93E-7 | SDT1 | Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives |
YDR490C | 4.82 | 7.02E-7 | PKH1 | Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p |
YOR070C | 4.82 | 7.25E-7 | GYP1 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
YBR151W | 4.70 | 1.29E-6 | APD1 | Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus |
YOR276W | 4.68 | 1.43E-6 | CAF20 | Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E |
YJR130C | 4.66 | 1.56E-6 | STR2 | Cystathionine gamma-synthase, converts cysteine into cystathionine |
YGL083W | 4.31 | 8.05E-6 | SCY1 | Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase |
YFL013C | 4.29 | 8.98E-6 | IES1 | Subunit of the INO80 chromatin remodeling complex |
YMR082C_d | 4.26 | 1.02E-5 | YMR082C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPR017C | 4.03 | 2.78E-5 | DSS4 | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
YDR094W_d | 4.02 | 2.85E-5 | YDR094W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 |