Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR013W | 4.90 | 4.68E-7 | 0.36 | SNU71 | Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart |
YML015C | 4.71 | 1.25E-6 | 0.36 | TAF11 | TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors |
YJL014W | 4.55 | 2.68E-6 | 0.36 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YPR190C | 4.31 | 8.03E-6 | 0.36 | RPC82 | RNA polymerase III subunit C82 |
YMR203W | 4.06 | 2.43E-5 | 0.36 | TOM40 | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore |
YBR038W | 3.70 | 1.08E-4 | 0.05 | CHS2 | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis |
YBR011C | 3.65 | 1.29E-4 | 0.00 | IPP1 | Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase |
YMR211W | 3.65 | 1.30E-4 | 0.04 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YMR281W | 3.61 | 1.53E-4 | 0.27 | GPI12 | ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp |
YJL111W | 3.34 | 4.14E-4 | 0.02 | CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
YMR301C | 3.32 | 4.45E-4 | 0.25 | ATM1 | Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol |
YHR069C | 3.07 | 0.00106 | 0.12 | RRP4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
YDR404C | 2.95 | 0.00159 | 0.02 | RPB7 | RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation |
YJL009W_d | 2.93 | 0.00167 | 0.05 | YJL009W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex |
YHR197W | 2.89 | 0.00195 | 0.05 | RIX1 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene |