Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR058C-A | 22.30 | 5.25E-110 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YPL120W | 7.26 | 1.92E-13 | VPS30 | Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 |
YPR100W | 6.48 | 4.48E-11 | MRPL51 | Mitochondrial ribosomal protein of the large subunit |
YML061C | 5.54 | 1.48E-8 | PIF1 | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
YER087W | 5.18 | 1.13E-7 | AIM10 | Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
YPL057C | 5.10 | 1.72E-7 | SUR1 | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication |
YBL027W | 4.98 | 3.22E-7 | RPL19B | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication |
YIL047C | 4.76 | 9.51E-7 | SYG1 | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency |
YPR074C | 4.46 | 4.02E-6 | TKL1 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
YDL032W_d | 4.40 | 5.50E-6 | YDL032W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene |
YAR047C_d | 4.25 | 1.05E-5 | YAR047C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YPL176C | 4.16 | 1.58E-5 | TRE1 | Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication |
YIL067C_p | 4.14 | 1.74E-5 | YIL067C_p | Uncharacterized protein of unknown function |
YLL057C | 4.14 | 1.75E-5 | JLP1 | Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation |
YBR069C | 4.10 | 2.07E-5 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |