Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YKL112W | 5.14 | 1.40E-7 | 0.35 | ABF1 | DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair |
YPL255W | 4.90 | 4.71E-7 | 0.35 | BBP1 | Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p |
YHR166C | 4.77 | 9.17E-7 | 0.35 | CDC23 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YDL064W | 4.48 | 3.68E-6 | 0.35 | UBC9 | SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) |
YLR076C_d | 4.14 | 1.76E-5 | 0.14 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YBR196C | 4.00 | 3.22E-5 | 0.18 | PGI1 | Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation |
YNL103W | 3.81 | 6.93E-5 | 0.24 | MET4 | Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p |
YER148W | 3.57 | 1.76E-4 | 0.06 | SPT15 | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
YMR093W | 3.51 | 2.23E-4 | 0.17 | UTP15 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YMR298W | 3.34 | 4.18E-4 | 0.01 | LIP1 | Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis |
YNL026W | 3.33 | 4.32E-4 | 0.08 | SAM50 | Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 |
YMR117C | 3.25 | 5.80E-4 | 0.01 | SPC24 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
YOR117W | 3.24 | 6.01E-4 | 0.10 | RPT5 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 |
YMR301C | 3.13 | 8.60E-4 | 0.08 | ATM1 | Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol |
YGR186W | 3.06 | 0.00112 | 0.08 | TFG1 | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 |