1486-1359

1-methyl-3-[(3-methylphenyl)carbamoyl]-1-methylsulfonylurea

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1340
Screen concentration 257.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 4309068
SMILES CC1=CC(=CC=C1)NC(=O)NC(=O)N(C)S(=O)(=O)C
Standardized SMILES CN(C(=O)NC(=O)Nc1cccc(C)c1)S(=O)(=O)C
Molecular weight 285.3195
ALogP 0.99
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 26.67
% growth inhibition (Hom. pool) 8.03


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4309068
Download HIP data (tab-delimited text)  (excel)
Gene:CDC34(YDR054C)|FD-Score:3.24|P-value:5.97E-4|Clearance:0.01||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CHS2(YBR038W)|FD-Score:-3.14|P-value:8.50E-4|Clearance:0||SGD DESC:Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis Gene:FCP1(YMR277W)|FD-Score:3.69|P-value:1.12E-4|Clearance:0.27||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:GLE1(YDL207W)|FD-Score:4.45|P-value:4.22E-6|Clearance:0.27||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:NUT2(YPR168W)|FD-Score:3.24|P-value:5.97E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress Gene:PKC1(YBL105C)|FD-Score:7.25|P-value:2.05E-13|Clearance:2.4||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRP28(YDR243C)|FD-Score:3.35|P-value:3.98E-4|Clearance:0.02||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:RAT1(YOR048C)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.03||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RER2(YBR002C)|FD-Score:-5.51|P-value:1.78E-8|Clearance:0||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPC82(YPR190C)|FD-Score:3.73|P-value:9.53E-5|Clearance:0.04||SGD DESC:RNA polymerase III subunit C82 Gene:RPR2(YIR015W)|FD-Score:4.19|P-value:1.42E-5|Clearance:0.45||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RPS5(YJR123W)|FD-Score:3.41|P-value:3.19E-4|Clearance:0.05||SGD DESC:Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 Gene:SDA1(YGR245C)|FD-Score:-3.25|P-value:5.68E-4|Clearance:0||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SPT15(YER148W)|FD-Score:4.85|P-value:6.15E-7|Clearance:0.4||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:UBA2(YDR390C)|FD-Score:-3.43|P-value:3.03E-4|Clearance:0||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:UTP7(YER082C)|FD-Score:-3.92|P-value:4.52E-5|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VHT1(YGR065C)|FD-Score:3.23|P-value:6.18E-4|Clearance:0.07||SGD DESC:High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin Gene:YJL015C(YJL015C_d)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W Gene:YLR198C(YLR198C_d)|FD-Score:3.34|P-value:4.21E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YLR339C(YLR339C_d)|FD-Score:3.16|P-value:7.86E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 Gene:CDC34(YDR054C)|FD-Score:3.24|P-value:5.97E-4|Clearance:0.01||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CHS2(YBR038W)|FD-Score:-3.14|P-value:8.50E-4|Clearance:0||SGD DESC:Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis Gene:FCP1(YMR277W)|FD-Score:3.69|P-value:1.12E-4|Clearance:0.27||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:GLE1(YDL207W)|FD-Score:4.45|P-value:4.22E-6|Clearance:0.27||SGD DESC:Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export Gene:NUT2(YPR168W)|FD-Score:3.24|P-value:5.97E-4|Clearance:0||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress Gene:PKC1(YBL105C)|FD-Score:7.25|P-value:2.05E-13|Clearance:2.4||SGD DESC:Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) Gene:PRP28(YDR243C)|FD-Score:3.35|P-value:3.98E-4|Clearance:0.02||SGD DESC:RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site Gene:RAT1(YOR048C)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.03||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RER2(YBR002C)|FD-Score:-5.51|P-value:1.78E-8|Clearance:0||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPC82(YPR190C)|FD-Score:3.73|P-value:9.53E-5|Clearance:0.04||SGD DESC:RNA polymerase III subunit C82 Gene:RPR2(YIR015W)|FD-Score:4.19|P-value:1.42E-5|Clearance:0.45||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RPS5(YJR123W)|FD-Score:3.41|P-value:3.19E-4|Clearance:0.05||SGD DESC:Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 Gene:SDA1(YGR245C)|FD-Score:-3.25|P-value:5.68E-4|Clearance:0||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SPT15(YER148W)|FD-Score:4.85|P-value:6.15E-7|Clearance:0.4||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:UBA2(YDR390C)|FD-Score:-3.43|P-value:3.03E-4|Clearance:0||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:UTP7(YER082C)|FD-Score:-3.92|P-value:4.52E-5|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VHT1(YGR065C)|FD-Score:3.23|P-value:6.18E-4|Clearance:0.07||SGD DESC:High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin Gene:YJL015C(YJL015C_d)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W Gene:YLR198C(YLR198C_d)|FD-Score:3.34|P-value:4.21E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YLR339C(YLR339C_d)|FD-Score:3.16|P-value:7.86E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4309068
Download HOP data (tab-delimited text)  (excel)
Gene:AIM26(YKL037W)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ASN2(YGR124W)|FD-Score:3.11|P-value:9.25E-4||SGD DESC:Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication Gene:BRE5(YNR051C)|FD-Score:3.82|P-value:6.68E-5||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:BUB2(YMR055C)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CAJ1(YER048C)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly Gene:CBS1(YDL069C)|FD-Score:-3.91|P-value:4.63E-5||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CMS1(YLR003C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:CUE1(YMR264W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:CUS2(YNL286W)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Gene:DDR2(YOL052C-A)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication Gene:DIG1(YPL049C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DLD2(YDL178W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:EFG1(YGR271C-A)|FD-Score:5.47|P-value:2.21E-8||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:ENT2(YLR206W)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Gene:ERP5(YHR110W)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:FAR11(YNL127W)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FYV12(YOR183W_p)|FD-Score:3.3|P-value:4.89E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:HAL1(YPR005C)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HBT1(YDL223C)|FD-Score:6.37|P-value:9.41E-11||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HOG1(YLR113W)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress Gene:HXT10(YFL011W)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:ICP55(YER078C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:INM2(YDR287W)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:IRC25(YLR021W)|FD-Score:-3.75|P-value:8.85E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:LIN1(YHR156C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication Gene:MBB1(YJL199C_d)|FD-Score:4.56|P-value:2.50E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:MEP3(YPR138C)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease Gene:MIP6(YHR015W)|FD-Score:4.3|P-value:8.64E-6||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:OST5(YGL226C-A)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PET127(YOR017W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane Gene:PHO23(YNL097C)|FD-Score:4.26|P-value:1.03E-5||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:POR1(YNL055C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PPT2(YPL148C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:PUS9(YDL036C)|FD-Score:-3.29|P-value:5.04E-4||SGD DESC:Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence Gene:RIM15(YFL033C)|FD-Score:4.21|P-value:1.25E-5||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RMD6(YEL072W)|FD-Score:-3.24|P-value:6.07E-4||SGD DESC:Protein required for sporulation Gene:RRG7(YOR305W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene Gene:RTC4(YNL254C)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:SAP30(YMR263W)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance Gene:SBH1(YER087C-B)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p Gene:SCJ1(YMR214W)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SCP160(YJL080C)|FD-Score:6.33|P-value:1.21E-10||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SCW11(YGL028C)|FD-Score:-3.98|P-value:3.48E-5||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SGE1(YPR198W)|FD-Score:3.9|P-value:4.79E-5||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SPA2(YLL021W)|FD-Score:5.08|P-value:1.84E-7||SGD DESC:Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate Gene:SSB1(YDL229W)|FD-Score:4.37|P-value:6.25E-6||SGD DESC:Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication Gene:TDH1(YJL052W)|FD-Score:-3.28|P-value:5.19E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TRM8(YDL201W)|FD-Score:4.61|P-value:2.02E-6||SGD DESC:Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:TRP5(YGL026C)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:TSC3(YBR058C-A)|FD-Score:-4.02|P-value:2.86E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TSR3(YOR006C)|FD-Score:6.17|P-value:3.43E-10||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YBL044W(YBL044W_p)|FD-Score:-3.12|P-value:9.11E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YBL086C(YBL086C_p)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YBL100W-C(YBL100W-C_p)|FD-Score:-4.04|P-value:2.65E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR072C-A(YBR072C-A_p)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR196C-B(YBR196C-B_p)|FD-Score:4.22|P-value:1.25E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YBR300C(YBR300C_d)|FD-Score:4.38|P-value:6.00E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YCL075W(YCL075W)|FD-Score:3.14|P-value:8.39E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YCR099C(YCR099C_p)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Putative protein of unknown function Gene:YDL162C(YDL162C_d)|FD-Score:-3.11|P-value:9.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Gene:YFL042C(YFL042C_p)|FD-Score:-3.1|P-value:9.82E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGL042C(YGL042C_d)|FD-Score:-5.74|P-value:4.65E-9||SGD DESC:Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Gene:YGL072C(YGL072C_d)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Gene:YHK8(YHR048W_p)|FD-Score:-3.43|P-value:2.98E-4||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YJU3(YKL094W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family Gene:YLR012C(YLR012C_p)|FD-Score:5.43|P-value:2.74E-8||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML002W(YML002W_p)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Putative protein of unknown function; expression induced by heat and by calcium shortage Gene:YML101C-A(YML101C-A_d)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:3.75|P-value:8.97E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR317W(YMR317W_p)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene Gene:YOP1(YPR028W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress Gene:YPL041C(YPL041C_p)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length Gene:YVH1(YIR026C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases Gene:ZRG8(YER033C)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency Gene:AIM26(YKL037W)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ASN2(YGR124W)|FD-Score:3.11|P-value:9.25E-4||SGD DESC:Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication Gene:BRE5(YNR051C)|FD-Score:3.82|P-value:6.68E-5||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:BUB2(YMR055C)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CAJ1(YER048C)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly Gene:CBS1(YDL069C)|FD-Score:-3.91|P-value:4.63E-5||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CMS1(YLR003C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:CUE1(YMR264W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:CUS2(YNL286W)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Gene:DDR2(YOL052C-A)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication Gene:DIG1(YPL049C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DLD2(YDL178W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:EFG1(YGR271C-A)|FD-Score:5.47|P-value:2.21E-8||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:ENT2(YLR206W)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Gene:ERP5(YHR110W)|FD-Score:3.98|P-value:3.50E-5||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:FAR11(YNL127W)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FYV12(YOR183W_p)|FD-Score:3.3|P-value:4.89E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:HAL1(YPR005C)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HBT1(YDL223C)|FD-Score:6.37|P-value:9.41E-11||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:HOG1(YLR113W)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress Gene:HXT10(YFL011W)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:ICP55(YER078C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:INM2(YDR287W)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:IRC25(YLR021W)|FD-Score:-3.75|P-value:8.85E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:LIN1(YHR156C)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication Gene:MBB1(YJL199C_d)|FD-Score:4.56|P-value:2.50E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:MEP3(YPR138C)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease Gene:MIP6(YHR015W)|FD-Score:4.3|P-value:8.64E-6||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:OST5(YGL226C-A)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:PET127(YOR017W)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane Gene:PHO23(YNL097C)|FD-Score:4.26|P-value:1.03E-5||SGD DESC:Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 Gene:POR1(YNL055C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PPT2(YPL148C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:PUS9(YDL036C)|FD-Score:-3.29|P-value:5.04E-4||SGD DESC:Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence Gene:RIM15(YFL033C)|FD-Score:4.21|P-value:1.25E-5||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RMD6(YEL072W)|FD-Score:-3.24|P-value:6.07E-4||SGD DESC:Protein required for sporulation Gene:RRG7(YOR305W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene Gene:RTC4(YNL254C)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:SAP30(YMR263W)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance Gene:SBH1(YER087C-B)|FD-Score:3.63|P-value:1.39E-4||SGD DESC:Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p Gene:SCJ1(YMR214W)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SCP160(YJL080C)|FD-Score:6.33|P-value:1.21E-10||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SCW11(YGL028C)|FD-Score:-3.98|P-value:3.48E-5||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SGE1(YPR198W)|FD-Score:3.9|P-value:4.79E-5||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SPA2(YLL021W)|FD-Score:5.08|P-value:1.84E-7||SGD DESC:Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate Gene:SSB1(YDL229W)|FD-Score:4.37|P-value:6.25E-6||SGD DESC:Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication Gene:TDH1(YJL052W)|FD-Score:-3.28|P-value:5.19E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:TRM8(YDL201W)|FD-Score:4.61|P-value:2.02E-6||SGD DESC:Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:TRP5(YGL026C)|FD-Score:-3.29|P-value:5.09E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:TSC3(YBR058C-A)|FD-Score:-4.02|P-value:2.86E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TSR3(YOR006C)|FD-Score:6.17|P-value:3.43E-10||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YBL044W(YBL044W_p)|FD-Score:-3.12|P-value:9.11E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YBL086C(YBL086C_p)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YBL100W-C(YBL100W-C_p)|FD-Score:-4.04|P-value:2.65E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBR072C-A(YBR072C-A_p)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR196C-B(YBR196C-B_p)|FD-Score:4.22|P-value:1.25E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YBR300C(YBR300C_d)|FD-Score:4.38|P-value:6.00E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Gene:YCL075W(YCL075W)|FD-Score:3.14|P-value:8.39E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YCR099C(YCR099C_p)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Putative protein of unknown function Gene:YDL162C(YDL162C_d)|FD-Score:-3.11|P-value:9.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Gene:YFL042C(YFL042C_p)|FD-Score:-3.1|P-value:9.82E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGL042C(YGL042C_d)|FD-Score:-5.74|P-value:4.65E-9||SGD DESC:Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Gene:YGL072C(YGL072C_d)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Gene:YHK8(YHR048W_p)|FD-Score:-3.43|P-value:2.98E-4||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YJU3(YKL094W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family Gene:YLR012C(YLR012C_p)|FD-Score:5.43|P-value:2.74E-8||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML002W(YML002W_p)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Putative protein of unknown function; expression induced by heat and by calcium shortage Gene:YML101C-A(YML101C-A_d)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:3.75|P-value:8.97E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR317W(YMR317W_p)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene Gene:YOP1(YPR028W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress Gene:YPL041C(YPL041C_p)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length Gene:YVH1(YIR026C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases Gene:ZRG8(YER033C)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBL105C7.252.05E-132.40PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YER148W4.856.15E-70.40SPT15TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YDL207W4.454.22E-60.27GLE1Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
YIR015W4.191.42E-50.45RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YPR190C3.739.53E-50.04RPC82RNA polymerase III subunit C82
YMR277W3.691.12E-40.28FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YJR123W3.413.19E-40.05RPS5Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
YJL015C_d3.373.82E-40.01YJL015C_dDubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
YDR243C3.353.98E-40.01PRP28RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YLR198C_d3.344.21E-40.07YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YOR048C3.275.33E-40.03RAT1Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YPR168W3.245.97E-41.35E-4NUT2Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
YDR054C3.245.97E-40.01CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
YGR065C3.236.18E-40.07VHT1High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YLR339C_d3.167.86E-40.13YLR339C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL223C6.379.41E-11HBT1Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YJL080C6.331.21E-10SCP160Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YOR006C6.173.43E-10TSR3Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
YGR271C-A5.472.21E-8EFG1Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YLR012C_p5.432.74E-8YLR012C_pPutative protein of unknown function; YLR012C is not an essential gene
YLL021W5.081.84E-7SPA2Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YDL201W4.612.02E-6TRM8Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
YJL199C_d4.562.50E-6MBB1_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YBR300C_d4.386.00E-6YBR300C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YDL229W4.376.25E-6SSB1Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
YHR015W4.308.64E-6MIP6Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication
YNL097C4.261.03E-5PHO23Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
YGL072C_d4.221.22E-5YGL072C_dDubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YBR196C-B_p4.221.25E-5YBR196C-B_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YFL033C4.211.25E-5RIM15Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase

GO enrichment analysis for SGTC_1340
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0848.30E-11SGTC_1793st048256 72.2 μMTimTec (Natural product derivative library)6720220.108108
0.0707.85E-8SGTC_32489135562 49.5 μMChembridge (Drug-like library)176507010.128571
0.0699.77E-8SGTC_13381486-1223 76.0 μMChemDiv (Drug-like library)34445260.40625
0.0663.78E-7SGTC_2129girgensonine 121.1 μMChembridge (Fragment library)4426380.0491803heme biosynthesis & mitochondrial translocase
0.0631.41E-6SGTC_30409091894 49.5 μMChembridge (Drug-like library)252369660.128571DNA intercalators
0.0621.90E-6SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.106061
0.0612.45E-6SGTC_1749st037932 54.2 μMTimTec (Natural product derivative library)5944970.0789474
0.0586.91E-6SGTC_13031160-0052 261.0 μMChemDiv (Drug-like library)35624760.121212
0.0571.07E-5SGTC_14934348-0038 111.0 μMChemDiv (Drug-like library)8004240.0746269RSC complex & mRNA processing
0.0561.44E-5SGTC_264promethazine 12.5 mMMiscellaneous60140.12069DNA intercalators
0.0561.61E-5SGTC_8540422-0053 192.0 μMChemDiv (Drug-like library)35967280.125PDR1
0.0561.64E-5SGTC_29689090663 33.4 μMChembridge (Drug-like library)252368110.19697
0.0552.57E-5SGTC_24755812728 15.0 μMMiscellaneous7761600.216667mitochondrial processes
0.0542.97E-5SGTC_2626ethyl orsellinate 100.0 μMMicrosource (Natural product library)756530.140351
0.0535.08E-5SGTC_13341486-0610 236.0 μMChemDiv (Drug-like library)37423390.03896160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13411486-1360280 μM0.73976547ChemDiv (Drug-like library)285.31950.99324
SGTC_1801486-1293102.78 μM0.4482764140536ChemDiv (Drug-like library)491.482815.57427
SGTC_13421486-1464234 μM0.4339623253938ChemDiv (Drug-like library)341.425822.77824
SGTC_1761486-132872.83 μM0.41269822310231ChemDiv (Drug-like library)511.901295.75327
SGTC_13381486-122376 μM0.406253444526ChemDiv (Drug-like library)483.503875.3727
SGTC_13391486-132122.7 μM0.4035093469382ChemDiv (Drug-like library)443.903324.8124ERG2
SGTC_21505556613200 μM0.392157743190Chembridge (Fragment library)213.235241.22813
SGTC_20134024628200 μM0.3877555230760Chembridge (Fragment library)226.273762.35422
SGTC_3411486-1430230 μM0.3818182054753ChemDiv (Drug-like library)347.817722.524
SGTC_13371486-101140.3 μM0.37931X1337ChemDiv (Drug-like library)443.903314.8142