1488-0192

6-[(4-chlorophenyl)sulfanylmethyl]imidazo[2,1-b][1,3]thiazole

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1345
Screen concentration 31.4 μM
Source ChemDiv (Drug-like library)
PubChem CID 658348
SMILES C1=CC(=CC=C1SCC2=CN3C=CSC3=N2)Cl
Standardized SMILES Clc1ccc(SCc2cn3ccsc3n2)cc1
Molecular weight 280.7963
ALogP 3.31
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.17
% growth inhibition (Hom. pool) 7.12


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 658348
Download HIP data (tab-delimited text)  (excel)
Gene:BRR2(YER172C)|FD-Score:3.31|P-value:4.74E-4|Clearance:0.15||SGD DESC:RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD Gene:COF1(YLL050C)|FD-Score:3.16|P-value:7.95E-4|Clearance:0.04||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:GNA1(YFL017C)|FD-Score:3.72|P-value:9.89E-5|Clearance:0.07||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:NOP8(YOL144W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.35||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:RPA43(YOR340C)|FD-Score:-4.57|P-value:2.44E-6|Clearance:0||SGD DESC:RNA polymerase I subunit A43 Gene:RPN12(YFR052W)|FD-Score:3.12|P-value:9.02E-4|Clearance:0.11||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:SPP381(YBR152W)|FD-Score:4.27|P-value:9.83E-6|Clearance:0.55||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:SRP54(YPR088C)|FD-Score:-5.7|P-value:5.84E-9|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:BRR2(YER172C)|FD-Score:3.31|P-value:4.74E-4|Clearance:0.15||SGD DESC:RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD Gene:COF1(YLL050C)|FD-Score:3.16|P-value:7.95E-4|Clearance:0.04||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:GNA1(YFL017C)|FD-Score:3.72|P-value:9.89E-5|Clearance:0.07||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:NOP8(YOL144W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.35||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:RPA43(YOR340C)|FD-Score:-4.57|P-value:2.44E-6|Clearance:0||SGD DESC:RNA polymerase I subunit A43 Gene:RPN12(YFR052W)|FD-Score:3.12|P-value:9.02E-4|Clearance:0.11||SGD DESC:Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress Gene:SPP381(YBR152W)|FD-Score:4.27|P-value:9.83E-6|Clearance:0.55||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:SRP54(YPR088C)|FD-Score:-5.7|P-value:5.84E-9|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 658348
Download HOP data (tab-delimited text)  (excel)
Gene:ADO1(YJR105W)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APE3(YBR286W)|FD-Score:4.44|P-value:4.48E-6||SGD DESC:Vacuolar aminopeptidase Y, processed to mature form by Prb1p Gene:BTS1(YPL069C)|FD-Score:-3.73|P-value:9.65E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CEM1(YER061C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CIT1(YNR001C)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:DBF2(YGR092W)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:ELP3(YPL086C)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:FRT1(YOR324C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:FSH1(YHR049W)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 Gene:FYV7(YLR068W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GCN4(YEL009C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:HMO1(YDR174W)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:HNT1(YDL125C)|FD-Score:3.82|P-value:6.62E-5||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:KIN82(YCR091W)|FD-Score:3.25|P-value:5.80E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:KRE1(YNL322C)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:MAC1(YMR021C)|FD-Score:-3.43|P-value:3.05E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MSC2(YDR205W)|FD-Score:4.34|P-value:7.24E-6||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids Gene:NDT80(YHR124W)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:NPR1(YNL183C)|FD-Score:4.48|P-value:3.68E-6||SGD DESC:Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex Gene:PAU7(YAR020C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PPH3(YDR075W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Gene:QCR6(YFR033C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RAD28(YDR030C)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair Gene:RCK1(YGL158W)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication Gene:RPL2A(YFR031C-A)|FD-Score:3.85|P-value:5.89E-5||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:RTS1(YOR014W)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SAT4(YCR008W)|FD-Score:6.73|P-value:8.73E-12||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SEC66(YBR171W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SEE1(YIL064W)|FD-Score:-3.74|P-value:9.15E-5||SGD DESC:Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport Gene:SLA2(YNL243W)|FD-Score:-3.41|P-value:3.29E-4||SGD DESC:Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo Gene:SLH1(YGR271W)|FD-Score:3.74|P-value:9.29E-5||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SNF2(YOR290C)|FD-Score:4.47|P-value:3.85E-6||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SPT2(YER161C)|FD-Score:7.51|P-value:2.93E-14||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:SUR2(YDR297W)|FD-Score:-3.18|P-value:7.32E-4||SGD DESC:Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis Gene:SUT1(YGL162W)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:THI2(YBR240C)|FD-Score:4.76|P-value:9.81E-7||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:TOP1(YOL006C)|FD-Score:5.44|P-value:2.66E-8||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:UBP9(YER098W)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication Gene:YBL012C(YBL012C_d)|FD-Score:6.08|P-value:6.13E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR013C(YBR013C_p)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YCL049C(YCL049C_p)|FD-Score:4.89|P-value:5.17E-7||SGD DESC:Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene Gene:YCR051W(YCR051W_p)|FD-Score:3.24|P-value:6.08E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDL026W(YDL026W_d)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR008C(YDR008C_d)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR149C(YDR149C_d)|FD-Score:3.29|P-value:4.97E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YFR020W(YFR020W_p)|FD-Score:5.11|P-value:1.59E-7||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Putative protein of unknown function Gene:YGR122W(YGR122W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YGR169C-A(YGR169C-A_p)|FD-Score:4.41|P-value:5.08E-6||SGD DESC:Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication Gene:YIL100W(YIL100W_d)|FD-Score:-4.85|P-value:6.10E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Gene:YLR053C(YLR053C_p)|FD-Score:3.31|P-value:4.63E-4||SGD DESC:Putative protein of unknown function Gene:YLR296W(YLR296W_d)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YND1(YER005W)|FD-Score:3.82|P-value:6.64E-5||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YOR296W(YOR296W_p)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene Gene:YPL109C(YPL109C_p)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPL257W(YPL257W_p)|FD-Score:3.42|P-value:3.09E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:ZDS2(YML109W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication Gene:ADO1(YJR105W)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APE3(YBR286W)|FD-Score:4.44|P-value:4.48E-6||SGD DESC:Vacuolar aminopeptidase Y, processed to mature form by Prb1p Gene:BTS1(YPL069C)|FD-Score:-3.73|P-value:9.65E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CEM1(YER061C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:CIT1(YNR001C)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:DBF2(YGR092W)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:ELP3(YPL086C)|FD-Score:-3.16|P-value:7.79E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:FRT1(YOR324C)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:FSH1(YHR049W)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 Gene:FYV7(YLR068W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin Gene:GCN4(YEL009C)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:HMO1(YDR174W)|FD-Score:-3.61|P-value:1.51E-4||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:HNT1(YDL125C)|FD-Score:3.82|P-value:6.62E-5||SGD DESC:Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress Gene:KIN82(YCR091W)|FD-Score:3.25|P-value:5.80E-4||SGD DESC:Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p Gene:KRE1(YNL322C)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:MAC1(YMR021C)|FD-Score:-3.43|P-value:3.05E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MSC2(YDR205W)|FD-Score:4.34|P-value:7.24E-6||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids Gene:NDT80(YHR124W)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:NPR1(YNL183C)|FD-Score:4.48|P-value:3.68E-6||SGD DESC:Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex Gene:PAU7(YAR020C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PPH3(YDR075W)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Gene:QCR6(YFR033C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RAD28(YDR030C)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair Gene:RCK1(YGL158W)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication Gene:RPL2A(YFR031C-A)|FD-Score:3.85|P-value:5.89E-5||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:RTS1(YOR014W)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SAT4(YCR008W)|FD-Score:6.73|P-value:8.73E-12||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SEC66(YBR171W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SEE1(YIL064W)|FD-Score:-3.74|P-value:9.15E-5||SGD DESC:Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport Gene:SLA2(YNL243W)|FD-Score:-3.41|P-value:3.29E-4||SGD DESC:Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo Gene:SLH1(YGR271W)|FD-Score:3.74|P-value:9.29E-5||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SNF2(YOR290C)|FD-Score:4.47|P-value:3.85E-6||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SPT2(YER161C)|FD-Score:7.51|P-value:2.93E-14||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:SUR2(YDR297W)|FD-Score:-3.18|P-value:7.32E-4||SGD DESC:Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis Gene:SUT1(YGL162W)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:THI2(YBR240C)|FD-Score:4.76|P-value:9.81E-7||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:TOP1(YOL006C)|FD-Score:5.44|P-value:2.66E-8||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:UBP9(YER098W)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication Gene:YBL012C(YBL012C_d)|FD-Score:6.08|P-value:6.13E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR013C(YBR013C_p)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YCL049C(YCL049C_p)|FD-Score:4.89|P-value:5.17E-7||SGD DESC:Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene Gene:YCR051W(YCR051W_p)|FD-Score:3.24|P-value:6.08E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene Gene:YDL026W(YDL026W_d)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR008C(YDR008C_d)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR149C(YDR149C_d)|FD-Score:3.29|P-value:4.97E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YFR020W(YFR020W_p)|FD-Score:5.11|P-value:1.59E-7||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.27|P-value:5.37E-4||SGD DESC:Putative protein of unknown function Gene:YGR122W(YGR122W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YGR169C-A(YGR169C-A_p)|FD-Score:4.41|P-value:5.08E-6||SGD DESC:Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication Gene:YIL100W(YIL100W_d)|FD-Score:-4.85|P-value:6.10E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Gene:YLR053C(YLR053C_p)|FD-Score:3.31|P-value:4.63E-4||SGD DESC:Putative protein of unknown function Gene:YLR296W(YLR296W_d)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YND1(YER005W)|FD-Score:3.82|P-value:6.64E-5||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YOR296W(YOR296W_p)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene Gene:YPL109C(YPL109C_p)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPL257W(YPL257W_p)|FD-Score:3.42|P-value:3.09E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:ZDS2(YML109W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR152W4.279.83E-60.55SPP381mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
YFL017C3.729.89E-50.07GNA1Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YOL144W3.651.31E-40.34NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YER172C3.314.74E-40.15BRR2RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
YLL050C3.167.95E-40.04COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YFR052W3.129.02E-40.11RPN12Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
YHR118C3.010.001290.03ORC6Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YDR228C2.980.001430.12PCF11mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
YIR011C2.860.002130.05STS1Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
YNL137C2.810.002490.00NAM9Mitochondrial ribosomal component of the small subunit
YOR103C2.800.002520.04OST2Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YDR308C2.770.002810.11SRB7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YIL104C2.660.003880.06SHQ1Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
YIL026C2.610.004570.02IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YPL131W2.590.004780.03RPL5Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER161C7.512.93E-14SPT2Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
YCR008W6.738.73E-12SAT4Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YBL012C_d6.086.13E-10YBL012C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL006C5.442.66E-8TOP1Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YFR020W_p5.111.59E-7YFR020W_pProtein of unknown function; mRNA identified as translated by ribosome profiling data
YCL049C_p4.895.17E-7YCL049C_pProtein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
YBR240C4.769.81E-7THI2Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YNL183C4.483.68E-6NPR1Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
YOR290C4.473.85E-6SNF2Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YBR286W4.444.48E-6APE3Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YGR169C-A_p4.415.08E-6YGR169C-A_pPutative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication
YDR205W4.347.24E-6MSC2Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
YBR171W4.211.30E-5SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YER061C3.993.27E-5CEM1Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YBR013C_p3.924.34E-5YBR013C_pPutative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein

GO enrichment analysis for SGTC_1345
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0937.77E-13SGTC_1906st060206 94.7 μMTimTec (Natural product derivative library)51334680.0615385
0.0912.14E-12SGTC_13541498-1681 81.0 μMChemDiv (Drug-like library)57542430.0470588
0.0857.51E-11SGTC_2667digitoxin 100.0 μMMicrosource (Natural product library)57020410.0192308
0.0791.15E-9SGTC_22456637752 200.0 μMChembridge (Fragment library)6818900.166667
0.0765.84E-9SGTC_11403229-1848 3.0 μMChemDiv (Drug-like library)28495250.0461538
0.0765.62E-9SGTC_1090132-0036 33.7 μMChemDiv (Drug-like library)672740.0434783
0.0766.21E-9SGTC_20155119600 184.0 μMChembridge (Fragment library)28287860.0454545
0.0723.45E-8SGTC_1791273-0063 6.8 μMChemDiv (Drug-like library)31081390.0588235
0.0681.88E-7SGTC_23739071805 200.0 μMChembridge (Fragment library)101490090.117647
0.0681.90E-7SGTC_305-(2-thienylidene)-Rhodanine 28.7 μMChemDiv (Drug-like library)12411320.0967742
0.0664.24E-7SGTC_13511496-0003 46.5 μMChemDiv (Drug-like library)38919780.0757576
0.0655.96E-7SGTC_267212a-hydroxy-5-deoxydehydromunduserone 100.0 μMMicrosource (Natural product library)46208980.0394737
0.0648.95E-7SGTC_2741miltefosine 3.0 μMMiscellaneous35990.015873
0.0631.10E-6SGTC_14414106-0040 13.0 μMChemDiv (Drug-like library)29041800.149254
0.0612.39E-6SGTC_22436634756 200.0 μMChembridge (Fragment library)8856760.135593

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13441488-009729.1 μM0.577778747966ChemDiv (Drug-like library)274.768543.57502
SGTC_9332914-0560114 μM0.534884463887ChemDiv (Drug-like library)234.704682.91302
SGTC_13823002-2117298 μM0.43751497314ChemDiv (Drug-like library)246.35122.7903
SGTC_7021488-019094 μM0.396226949357ChemDiv (Drug-like library)339.273844.1103amide catabolism
SGTC_11931488-012641.5 μM0.3636361384710ChemDiv (Drug-like library)354.652664.17303
SGTC_11941488-0194225 μM0.2758621391452ChemDiv (Drug-like library)355.276542.93205
SGTC_11921488-009521.4 μM0.258621915875ChemDiv (Drug-like library)333.246124.37902
SGTC_1942st07633065.2 μM0.23809524208414TimTec (Natural product derivative library)306.770642.72813
SGTC_14894065-0444182 μM0.2343752877968ChemDiv (Drug-like library)366.288065.9604
SGTC_222nsc-31034210.67 μM0.220339432556Miscellaneous268.722662.25525