| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBR114W | 6.81 | 5.04E-12 | RAD16 | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex |
| YPR068C | 5.93 | 1.55E-9 | HOS1 | Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex |
| YJL082W | 5.48 | 2.07E-8 | IML2 | Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication |
| YDR424C | 5.33 | 5.00E-8 | DYN2 | Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex |
| YPR017C | 5.30 | 5.87E-8 | DSS4 | Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol |
| YLR134W | 5.26 | 7.14E-8 | PDC5 | Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism |
| YMR247C | 5.24 | 7.89E-8 | RKR1 | RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice |
| YIL096C_p | 5.20 | 1.02E-7 | YIL096C_p | Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis |
| YPR012W_d | 4.86 | 5.85E-7 | YPR012W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene |
| YDR147W | 4.82 | 7.11E-7 | EKI1 | Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication |
| YOR177C | 4.64 | 1.73E-6 | MPC54 | Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate |
| YOR100C | 4.40 | 5.53E-6 | CRC1 | Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
| YIR036C_p | 4.39 | 5.58E-6 | IRC24_p | Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci |
| YMR175W-A_p | 4.33 | 7.53E-6 | YMR175W-A_p | Putative protein of unknown function |
| YDR445C_d | 4.25 | 1.09E-5 | YDR445C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
