Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR007W | 9.10 | 4.44E-20 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YGL026C | 7.93 | 1.08E-15 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YOL119C | 6.67 | 1.24E-11 | MCH4 | Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport |
YDR127W | 6.02 | 8.74E-10 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YDR008C_d | 5.73 | 5.16E-9 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR354W | 5.30 | 5.66E-8 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YDR159W | 4.99 | 3.03E-7 | SAC3 | Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) |
YOL076W | 4.70 | 1.30E-6 | MDM20 | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly |
YLL032C | 4.69 | 1.36E-6 | YLL032C | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene |
YOR201C | 4.62 | 1.91E-6 | MRM1 | Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA |
YKR026C | 4.54 | 2.78E-6 | GCN3 | Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression |
YAL044C | 4.53 | 2.92E-6 | GCV3 | H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF |
YJR154W_p | 4.49 | 3.55E-6 | YJR154W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YBR021W | 4.42 | 4.94E-6 | FUR4 | Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation |
YHR135C | 4.41 | 5.17E-6 | YCK1 | Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication |