Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL231W | 3.83 | 6.46E-5 | 0.34 | FAS2 | Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities |
YKR062W | 3.49 | 2.43E-4 | 0.16 | TFA2 | TFIIE small subunit, involved in RNA polymerase II transcription initiation |
YOR272W | 3.33 | 4.33E-4 | 0.28 | YTM1 | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats |
YMR005W | 3.05 | 0.00114 | 0.12 | TAF4 | TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate |
YCL041C_d | 2.93 | 0.00170 | 0.03 | YCL041C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W |
YKL172W | 2.90 | 0.00187 | 0.04 | EBP2 | Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering |
YPL082C | 2.86 | 0.00212 | 0.02 | MOT1 | Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA |
YMR308C | 2.84 | 0.00222 | 0.00 | PSE1 | Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p |
YGL068W | 2.84 | 0.00224 | 0.06 | MNP1 | Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth |
YDR002W | 2.79 | 0.00266 | 0.22 | YRB1 | Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 |
YMR049C | 2.56 | 0.00518 | 0.01 | ERB1 | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 |
YBR089W_d | 2.55 | 0.00541 | 0.01 | YBR089W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 |
YDR172W | 2.54 | 0.00552 | 0.01 | SUP35 | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
YPL252C | 2.53 | 0.00572 | 0.05 | YAH1 | Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin |
YPR108W | 2.48 | 0.00650 | 0.07 | RPN7 | Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits |