Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR074C | 8.25 | 7.78E-17 | TKL1 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
YHR161C | 6.34 | 1.16E-10 | YAP1801 | Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication |
YCR024C-A | 4.71 | 1.26E-6 | PMP1 | Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication |
YNL155W_p | 4.70 | 1.31E-6 | YNL155W_p | Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress |
YLR073C | 4.67 | 1.51E-6 | RFU1 | Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes |
YPR004C | 4.64 | 1.76E-6 | AIM45 | Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response |
YIL105C | 4.54 | 2.82E-6 | SLM1 | Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication |
YDR125C | 4.49 | 3.50E-6 | ECM18 | Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication |
YOL114C_p | 4.49 | 3.53E-6 | YOL114C_p | Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene |
YPL140C | 4.36 | 6.52E-6 | MKK2 | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication |
YDR253C | 4.32 | 7.85E-6 | MET32 | Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication |
YNR071C_p | 4.24 | 1.10E-5 | YNR071C_p | Putative aldose 1-epimerase |
YJR047C | 4.21 | 1.25E-5 | ANB1 | Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication |
YOR124C | 4.11 | 1.94E-5 | UBP2 | Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity |
YNL032W | 4.10 | 2.10E-5 | SIW14 | Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm |