Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBR002C | 8.05 | 4.02E-16 | 0.53 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YLR033W | 7.62 | 1.24E-14 | 0.53 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YCR052W | 7.60 | 1.47E-14 | 0.53 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YMR290W-A_d | 7.50 | 3.20E-14 | 0.53 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YPR107C | 7.16 | 3.97E-13 | 0.53 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YER133W | 6.63 | 1.62E-11 | 0.26 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YEL035C_p | 6.38 | 9.10E-11 | 0.50 | UTR5_p | Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions |
YEL034W | 5.87 | 2.14E-9 | 0.22 | HYP2 | Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication |
YJL086C_d | 5.65 | 8.07E-9 | 0.07 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |
YGR114C_d | 5.58 | 1.19E-8 | 0.05 | YGR114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 |
YGR029W | 5.53 | 1.57E-8 | 0.21 | ERV1 | Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) |
YLR060W | 5.32 | 5.08E-8 | 0.07 | FRS1 | Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control |
YML127W | 5.25 | 7.42E-8 | 0.45 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YOL144W | 4.81 | 7.66E-7 | 0.03 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YKL058W | 4.78 | 8.89E-7 | 0.03 | TOA2 | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress |