Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YMR290W-A_d | 6.30 | 1.53E-10 | 1.38 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YER094C | 4.92 | 4.41E-7 | 0.15 | PUP3 | Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
YOR224C | 4.77 | 9.39E-7 | 0.07 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YKL018W | 4.69 | 1.35E-6 | 0.33 | SWD2 | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination |
YPL093W | 4.37 | 6.31E-6 | 0.01 | NOG1 | Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins |
YLL036C | 4.35 | 6.70E-6 | 0.04 | PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain |
YDL004W | 4.31 | 8.20E-6 | 0.05 | ATP16 | Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated |
YKL004W | 4.26 | 1.04E-5 | 0.18 | AUR1 | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
YNR016C | 4.08 | 2.28E-5 | 0.45 | ACC1 | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
YBR254C | 3.63 | 1.41E-4 | 0.03 | TRS20 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder |
YPR105C | 3.61 | 1.56E-4 | 0.04 | COG4 | Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YDL196W_d | 3.56 | 1.82E-4 | 0.25 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YKR038C | 3.32 | 4.53E-4 | 0.08 | KAE1 | Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription |
YAR007C | 3.24 | 6.02E-4 | 0.02 | RFA1 | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
YML010W | 3.22 | 6.36E-4 | 0.08 | SPT5 | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair |