Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL235W | 9.30 | 6.85E-21 | 3.69 | RVB2 | ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly |
YKL180W | 5.61 | 1.00E-8 | 0.33 | RPL17A | Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YML085C | 5.28 | 6.30E-8 | 0.08 | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
YMR203W | 5.21 | 9.61E-8 | 0.46 | TOM40 | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore |
YHR036W | 4.75 | 1.04E-6 | 0.03 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YGL055W | 4.72 | 1.20E-6 | 0.37 | OLE1 | Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria |
YLL018C | 4.35 | 6.83E-6 | 0.15 | DPS1 | Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation |
YKL028W | 4.20 | 1.35E-5 | 0.18 | TFA1 | TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening |
YOR319W | 4.02 | 2.92E-5 | 0.25 | HSH49 | U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) |
YBL074C | 3.77 | 8.19E-5 | 0.01 | AAR2 | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
YDR047W | 3.76 | 8.58E-5 | 0.00 | HEM12 | Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda |
YHR074W | 3.75 | 8.69E-5 | 0.16 | QNS1 | Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide |
YGR083C | 3.59 | 1.63E-4 | 0.02 | GCD2 | Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YJR006W | 3.57 | 1.76E-4 | 0.14 | POL31 | Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair |
YDR145W | 3.43 | 3.01E-4 | 0.13 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |