3455-1037

ethyl 4,6-bis[(dimethylamino)methyl]-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1392
Screen concentration 33.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 981132
SMILES CCOC(=O)C1=C(OC2=C1C(=C(C(=C2)CN(C)C)O)CN(C)C)C3=CC=CC=C3
Standardized SMILES CCOC(=O)c1c(oc2cc(CN(C)C)c(O)c(CN(C)C)c12)c3ccccc3
Molecular weight 396.4794
ALogP 4.05
H-bond donor count 1
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.93
% growth inhibition (Hom. pool) 1.32


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 981132
Download HIP data (tab-delimited text)  (excel)
Gene:APC2(YLR127C)|FD-Score:3.21|P-value:6.75E-4|Clearance:0.03||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p Gene:APC5(YOR249C)|FD-Score:-4.64|P-value:1.74E-6|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress Gene:CDC27(YBL084C)|FD-Score:3.18|P-value:7.38E-4|Clearance:0.14||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CDC36(YDL165W)|FD-Score:3.38|P-value:3.66E-4|Clearance:0.02||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:LSG1(YGL099W)|FD-Score:7.61|P-value:1.33E-14|Clearance:4.22||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM7(YBR202W)|FD-Score:-3.42|P-value:3.16E-4|Clearance:0||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:MRD1(YPR112C)|FD-Score:3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:NSA2(YER126C)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.03||SGD DESC:Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA Gene:RPL30(YGL030W)|FD-Score:-3.55|P-value:1.95E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:SPT14(YPL175W)|FD-Score:3.4|P-value:3.39E-4|Clearance:0.02||SGD DESC:UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins Gene:UTP18(YJL069C)|FD-Score:-3.36|P-value:3.88E-4|Clearance:0||SGD DESC:Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data Gene:YBL077W(YBL077W_d)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Gene:YPR136C(YPR136C_d)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 Gene:APC2(YLR127C)|FD-Score:3.21|P-value:6.75E-4|Clearance:0.03||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p Gene:APC5(YOR249C)|FD-Score:-4.64|P-value:1.74E-6|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress Gene:CDC27(YBL084C)|FD-Score:3.18|P-value:7.38E-4|Clearance:0.14||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CDC36(YDL165W)|FD-Score:3.38|P-value:3.66E-4|Clearance:0.02||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:LSG1(YGL099W)|FD-Score:7.61|P-value:1.33E-14|Clearance:4.22||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM7(YBR202W)|FD-Score:-3.42|P-value:3.16E-4|Clearance:0||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:MRD1(YPR112C)|FD-Score:3.36|P-value:3.92E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:NSA2(YER126C)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.03||SGD DESC:Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA Gene:RPL30(YGL030W)|FD-Score:-3.55|P-value:1.95E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:SPT14(YPL175W)|FD-Score:3.4|P-value:3.39E-4|Clearance:0.02||SGD DESC:UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins Gene:UTP18(YJL069C)|FD-Score:-3.36|P-value:3.88E-4|Clearance:0||SGD DESC:Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data Gene:YBL077W(YBL077W_d)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Gene:YPR136C(YPR136C_d)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 981132
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:4.64|P-value:1.71E-6||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:AHC2(YCR082W)|FD-Score:-4.02|P-value:2.88E-5||SGD DESC:Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex Gene:ALE1(YOR175C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:APL3(YBL037W)|FD-Score:3.76|P-value:8.43E-5||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:BRE1(YDL074C)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:BRE5(YNR051C)|FD-Score:3.1|P-value:9.83E-4||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:CAN1(YEL063C)|FD-Score:4.48|P-value:3.70E-6||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:DAL7(YIR031C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DFG5(YMR238W)|FD-Score:4.09|P-value:2.20E-5||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:ELM1(YKL048C)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:FLC2(YAL053W)|FD-Score:7.88|P-value:1.68E-15||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FMO1(YHR176W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FYV6(YNL133C)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GFD1(YMR255W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GSP2(YOR185C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress Gene:HSL1(YKL101W)|FD-Score:5.32|P-value:5.16E-8||SGD DESC:Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p Gene:IMD3(YLR432W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed Gene:KTI12(YKL110C)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p Gene:LST7(YGR057C)|FD-Score:3.28|P-value:5.14E-4||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MAC1(YMR021C)|FD-Score:8.58|P-value:4.67E-18||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAE1(YKL029C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids Gene:MDG1(YNL173C)|FD-Score:3.78|P-value:7.75E-5||SGD DESC:Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations Gene:MET32(YDR253C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MNL1(YHR204W)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:MPM1(YJL066C)|FD-Score:4.03|P-value:2.77E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRPL51(YPR100W)|FD-Score:-4.36|P-value:6.57E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSY1(YPL097W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:PET54(YGR222W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PEX13(YLR191W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:RBK1(YCR036W)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative ribokinase Gene:RGT1(YKL038W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:ROM2(YLR371W)|FD-Score:-3.63|P-value:1.41E-4||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPS29A(YLR388W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RPS6A(YPL090C)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SEH1(YGL100W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:SET3(YKR029C)|FD-Score:-3.8|P-value:7.34E-5||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SNF4(YGL115W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SPS2(YDR522C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:TAT1(YBR069C)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TPO3(YPR156C)|FD-Score:-4.19|P-value:1.40E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-3.9|P-value:4.90E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP4(YDR354W)|FD-Score:-5.45|P-value:2.46E-8||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UBP11(YKR098C)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:UGA1(YGR019W)|FD-Score:-3.4|P-value:3.41E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:UGA2(YBR006W)|FD-Score:6.05|P-value:7.06E-10||SGD DESC:Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Gene:VFA1(YER128W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology Gene:VMA7(YGR020C)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YBL029W(YBL029W_p)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Non-essential protein of unknown function Gene:YCL042W(YCL042W_p)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDL034W(YDL034W_d)|FD-Score:-3.19|P-value:7.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene Gene:YDL114W(YDL114W_p)|FD-Score:-3.2|P-value:6.94E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YHK8(YHR048W_p)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YKR104W(YKR104W)|FD-Score:3.75|P-value:8.97E-5||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.97|P-value:3.56E-5||SGD DESC:Putative protein of unknown function Gene:YMR130W(YMR130W_p)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YMR130W is not an essential gene Gene:YNL108C(YNL108C_p)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication Gene:YNL115C(YNL115C_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene Gene:YPL114W(YPL114W_d)|FD-Score:3.88|P-value:5.14E-5||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Gene:YPL261C(YPL261C_d)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Gene:YPR099C(YPR099C_d)|FD-Score:-3.35|P-value:4.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Gene:ADE4(YMR300C)|FD-Score:4.64|P-value:1.71E-6||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:AHC2(YCR082W)|FD-Score:-4.02|P-value:2.88E-5||SGD DESC:Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex Gene:ALE1(YOR175C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:APL3(YBL037W)|FD-Score:3.76|P-value:8.43E-5||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:BRE1(YDL074C)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:BRE5(YNR051C)|FD-Score:3.1|P-value:9.83E-4||SGD DESC:Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A Gene:CAN1(YEL063C)|FD-Score:4.48|P-value:3.70E-6||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:DAL7(YIR031C)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:DFG5(YMR238W)|FD-Score:4.09|P-value:2.20E-5||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:ELM1(YKL048C)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:FLC2(YAL053W)|FD-Score:7.88|P-value:1.68E-15||SGD DESC:Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication Gene:FMO1(YHR176W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:FYV6(YNL133C)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GFD1(YMR255W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GSP2(YOR185C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress Gene:HSL1(YKL101W)|FD-Score:5.32|P-value:5.16E-8||SGD DESC:Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p Gene:IMD3(YLR432W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed Gene:KTI12(YKL110C)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p Gene:LST7(YGR057C)|FD-Score:3.28|P-value:5.14E-4||SGD DESC:Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface Gene:MAC1(YMR021C)|FD-Score:8.58|P-value:4.67E-18||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MAE1(YKL029C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids Gene:MDG1(YNL173C)|FD-Score:3.78|P-value:7.75E-5||SGD DESC:Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations Gene:MET32(YDR253C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication Gene:MNL1(YHR204W)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:MPM1(YJL066C)|FD-Score:4.03|P-value:2.77E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRPL51(YPR100W)|FD-Score:-4.36|P-value:6.57E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSY1(YPL097W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Mitochondrial tyrosyl-tRNA synthetase Gene:PET54(YGR222W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PEX13(YLR191W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:RBK1(YCR036W)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative ribokinase Gene:RGT1(YKL038W)|FD-Score:3.19|P-value:7.10E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:ROM2(YLR371W)|FD-Score:-3.63|P-value:1.41E-4||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPS29A(YLR388W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RPS6A(YPL090C)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SEH1(YGL100W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:SET3(YKR029C)|FD-Score:-3.8|P-value:7.34E-5||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SNF4(YGL115W)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress Gene:SPS2(YDR522C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:TAT1(YBR069C)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TPO3(YPR156C)|FD-Score:-4.19|P-value:1.40E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-3.9|P-value:4.90E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP4(YDR354W)|FD-Score:-5.45|P-value:2.46E-8||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UBP11(YKR098C)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins Gene:UGA1(YGR019W)|FD-Score:-3.4|P-value:3.41E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:UGA2(YBR006W)|FD-Score:6.05|P-value:7.06E-10||SGD DESC:Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Gene:VFA1(YER128W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology Gene:VMA7(YGR020C)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YBL029W(YBL029W_p)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Non-essential protein of unknown function Gene:YCL042W(YCL042W_p)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YDL034W(YDL034W_d)|FD-Score:-3.19|P-value:7.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene Gene:YDL114W(YDL114W_p)|FD-Score:-3.2|P-value:6.94E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YHK8(YHR048W_p)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YKR104W(YKR104W)|FD-Score:3.75|P-value:8.97E-5||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.97|P-value:3.56E-5||SGD DESC:Putative protein of unknown function Gene:YMR130W(YMR130W_p)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YMR130W is not an essential gene Gene:YNL108C(YNL108C_p)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication Gene:YNL115C(YNL115C_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene Gene:YPL114W(YPL114W_d)|FD-Score:3.88|P-value:5.14E-5||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Gene:YPL261C(YPL261C_d)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Gene:YPR099C(YPR099C_d)|FD-Score:-3.35|P-value:4.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL099W7.611.33E-144.22LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YPL175W3.403.39E-40.02SPT14UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
YDL165W3.383.66E-40.02CDC36Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YPR112C3.363.92E-40.00MRD1Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
YER126C3.363.95E-40.03NSA2Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YBL077W_d3.334.33E-40.13YBL077W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YLR127C3.216.75E-40.03APC2Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
YBL084C3.187.38E-40.14CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YKR081C3.040.001180.03RPF2Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YIL004C3.010.001320.01BET1Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YOR335C3.000.001370.04ALA1Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YOR294W2.960.001550.08RRS1Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
YHR170W2.880.002000.09NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YGL113W2.790.002620.00SLD3Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
YMR001C2.790.002630.04CDC5Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR021C8.584.67E-18MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YAL053W7.881.68E-15FLC2Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
YBR006W6.057.06E-10UGA2Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YKL101W5.325.16E-8HSL1Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YKL212W4.681.41E-6SAC1Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
YMR300C4.641.71E-6ADE4Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YEL063C4.483.70E-6CAN1Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
YPL261C_d4.111.94E-5YPL261C_dDubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YHR204W4.092.18E-5MNL1Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
YMR238W4.092.20E-5DFG5Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
YGL115W4.062.41E-5SNF4Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
YHR048W_p4.052.60E-5YHK8_pPresumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YPL090C4.042.63E-5RPS6AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
YJL066C4.032.77E-5MPM1Mitochondrial intermembrane space protein of unknown function
YMR001C-A_p3.973.56E-5YMR001C-A_pPutative protein of unknown function

GO enrichment analysis for SGTC_1392
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1448.82E-29SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.11340260S ribosome export
0.1441.09E-28SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.160S ribosome export
0.1322.93E-24SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.092105360S ribosome export
0.1189.78E-20SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.10344860S ribosome export
0.1127.95E-18SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.13636460S ribosome export
0.1071.64E-16SGTC_8660495-0101 262.0 μMChemDiv (Drug-like library)6356940.10588260S ribosome export
0.1072.23E-16SGTC_22067254556 147.0 μMChembridge (Fragment library)43989050.10256460S ribosome export
0.1048.62E-16SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.088607660S ribosome export
0.1001.32E-14SGTC_1081sertraline 6.0 μMNIH Clinical Collection630090.090909160S ribosome export
0.0992.72E-14SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.12195160S ribosome export
0.0984.22E-14SGTC_6653914-0008 307.0 μMChemDiv (Drug-like library)10695490.174419
0.0984.67E-14SGTC_2774tamoxifen 10.9 μMMiscellaneous27335260.197183
0.0961.16E-13SGTC_1619st003326 88.7 μMTimTec (Natural product derivative library)28490320.077922160S ribosome export
0.0952.13E-13SGTC_15924',5'-dihydroxyflavone 8.8 μMTimTec (Pure natural product library)6886690.11688360S ribosome export
0.0944.80E-13SGTC_1971st069429 63.5 μMTimTec (Natural product derivative library)12465220.12195160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_397arbidol50 μM0.445946131410Miscellaneous531.890725.49136cell wall
SGTC_1665st01463911.4 μM0.379747981133TimTec (Natural product derivative library)511.859565.98115NEO1
SGTC_1612st00223345.4 μM0.3466671035021TimTec (Natural product derivative library)431.322924.99304
SGTC_530973-002339.98 μM0.34375674768ChemDiv (Drug-like library)261.33943.3714RNA processing & uracil transport
SGTC_2113455-0679143.5 μM0.34375748649ChemDiv (Drug-like library)220.221282.87314
SGTC_2626ethyl orsellinate100 μM0.31666775653Microsource (Natural product library)196.199882.03624
SGTC_2506ethyl hematommate54.16 μM0.31253940691Microsource (Natural product library)224.209981.79525RPP1 & pyrimidine depletion
SGTC_1563474-01455.64 μM0.3026322265471ChemDiv (Drug-like library)419.269163.50305endomembrane recycling
SGTC_2406ethylparaben405.7 μM0.2982468434Miscellaneous166.17391.79213
SGTC_11750741-005627.6 μM0.291667765927ChemDiv (Drug-like library)318.321223.61826