3532-0190

3-hydroxy-4-methyl-7,8,9,10-tetrahydrobenzo[c]chromen-6-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1397
Screen concentration 20.1 μM
Source ChemDiv (Drug-like library)
PubChem CID 5322280
SMILES CC1=C(C=CC2=C1OC(=O)C3=C2CCCC3)O
Standardized SMILES Cc1c(O)ccc2C3=C(CCCC3)C(=O)Oc12
Molecular weight 230.2592
ALogP 3.58
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.74
% growth inhibition (Hom. pool) 4.21


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5322280
Download HIP data (tab-delimited text)  (excel)
Gene:MCM3(YEL032W)|FD-Score:3.26|P-value:5.63E-4|Clearance:0.22||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Gene:TIF34(YMR146C)|FD-Score:4.52|P-value:3.11E-6|Clearance:1.26||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:YTH1(YPR107C)|FD-Score:5.63|P-value:8.87E-9|Clearance:1.26||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:MCM3(YEL032W)|FD-Score:3.26|P-value:5.63E-4|Clearance:0.22||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Gene:TIF34(YMR146C)|FD-Score:4.52|P-value:3.11E-6|Clearance:1.26||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:YTH1(YPR107C)|FD-Score:5.63|P-value:8.87E-9|Clearance:1.26||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5322280
Download HOP data (tab-delimited text)  (excel)
Gene:AAT2(YLR027C)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:ACE2(YLR131C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AMA1(YGR225W)|FD-Score:-3.46|P-value:2.71E-4||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:ARL1(YBR164C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:AVT6(YER119C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:GAL4(YPL248C)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Gene:IDH2(YOR136W)|FD-Score:4.33|P-value:7.43E-6||SGD DESC:Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated Gene:IML3(YBR107C)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 Gene:MSN1(YOL116W)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:PEP7(YDR323C)|FD-Score:3.93|P-value:4.26E-5||SGD DESC:Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Gene:PIN3(YPR154W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT6(YGR199W)|FD-Score:-3.2|P-value:6.85E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases Gene:SET3(YKR029C)|FD-Score:-5.91|P-value:1.69E-9||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SRC1(YML034W)|FD-Score:3.89|P-value:5.07E-5||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:SSN2(YDR443C)|FD-Score:4.98|P-value:3.24E-7||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:VPS5(YOR069W)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:YBR238C(YBR238C)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YGR121W-A(YGR121W-A_p)|FD-Score:4.86|P-value:5.99E-7||SGD DESC:Putative protein of unknown function Gene:YKR104W(YKR104W)|FD-Score:4.04|P-value:2.72E-5||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YOL114C(YOL114C_p)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene Gene:YOR1(YGR281W)|FD-Score:5.67|P-value:7.29E-9||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) Gene:YOR338W(YOR338W_p)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication Gene:AAT2(YLR027C)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:ACE2(YLR131C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:AMA1(YGR225W)|FD-Score:-3.46|P-value:2.71E-4||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:ARL1(YBR164C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Gene:AVT6(YER119C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:GAL4(YPL248C)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Gene:IDH2(YOR136W)|FD-Score:4.33|P-value:7.43E-6||SGD DESC:Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated Gene:IML3(YBR107C)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 Gene:MSN1(YOL116W)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:PEP7(YDR323C)|FD-Score:3.93|P-value:4.26E-5||SGD DESC:Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Gene:PIN3(YPR154W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT6(YGR199W)|FD-Score:-3.2|P-value:6.85E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases Gene:SET3(YKR029C)|FD-Score:-5.91|P-value:1.69E-9||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SRC1(YML034W)|FD-Score:3.89|P-value:5.07E-5||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:SSN2(YDR443C)|FD-Score:4.98|P-value:3.24E-7||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation Gene:VPS5(YOR069W)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:YBR238C(YBR238C)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YGR121W-A(YGR121W-A_p)|FD-Score:4.86|P-value:5.99E-7||SGD DESC:Putative protein of unknown function Gene:YKR104W(YKR104W)|FD-Score:4.04|P-value:2.72E-5||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YOL114C(YOL114C_p)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene Gene:YOR1(YGR281W)|FD-Score:5.67|P-value:7.29E-9||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) Gene:YOR338W(YOR338W_p)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR107C5.638.87E-91.26YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YMR146C4.523.11E-61.26TIF34eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
YEL032W3.265.63E-40.22MCM3Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBR202W3.040.001190.08MCM7Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
YHR088W2.960.001560.03RPF1Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YMR218C2.920.001740.06TRS130One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
YOR250C2.860.002130.05CLP1Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
YGR158C2.800.002520.04MTR3Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
YKL180W2.760.002890.02RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YML127W2.740.003070.02RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YDR449C2.720.003250.16UTP6Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR045C2.560.005180.03RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YNL110C2.540.005570.01NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YGL008C2.530.005720.00PMA1Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
YGR116W2.520.005790.06SPT6Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR281W5.677.29E-9YOR1Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)
YDR443C4.983.24E-7SSN2Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
YGR121W-A_p4.865.99E-7YGR121W-A_pPutative protein of unknown function
YOR136W4.337.43E-6IDH2Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
YBR238C4.042.65E-5YBR238CMitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YKR104W4.042.72E-5YKR104WPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YDR323C3.934.26E-5PEP7Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
YML034W3.895.07E-5SRC1Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
YOL114C_p3.701.09E-4YOL114C_pPutative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
YPR154W3.512.25E-4PIN3Protein that induces appearance of [PIN+] prion when overproduced
YER119C3.462.72E-4AVT6Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication
YPR198W3.442.92E-4SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YBR107C3.413.22E-4IML3Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
YLR027C3.403.34E-4AAT2Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YPL248C3.363.85E-4GAL4DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p

GO enrichment analysis for SGTC_1397
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1751.35E-41SGTC_30641327-0027 10.0 μMChemDiv (Drug-like library)160004550.056338
0.1661.10E-37SGTC_30591327-0034 3.0 μMChemDiv (Drug-like library)159985800.0869565
0.1391.48E-26SGTC_30631327-0034 4.0 μMChemDiv (Drug-like library)159985800.0869565
0.1331.47E-24SGTC_30601327-0027 12.5 μMChemDiv (Drug-like library)160004550.056338
0.1288.13E-23SGTC_9841492-0255 2.9 μMChemDiv (Drug-like library)15851980.047619SWF1 & branched chain AA biosynthesis
0.1262.35E-22SGTC_24295902844 64.4 μMMiscellaneous19277900.118644
0.1101.91E-17SGTC_1070358-0022 2.7 μMChemDiv (Drug-like library)5211060.148936SWF1 & branched chain AA biosynthesis
0.1032.49E-15SGTC_5860957-0265 8.2 μMChemDiv (Drug-like library)67523090.126582cell wall
0.1024.37E-15SGTC_12550566-0045 221.0 μMChemDiv (Drug-like library)27884690.0806452excess fatty acid
0.0984.25E-14SGTC_117lucigenin 22.1 μMChemDiv (Drug-like library)651000.0869565redox potentiating
0.0971.13E-13SGTC_216k038-0035 28.4 μMChemDiv (Drug-like library)44442310.0645161ubiquinone biosynthesis & proteasome
0.0944.72E-13SGTC_1968st069590 43.6 μMTimTec (Natural product derivative library)63840660.0769231
0.0912.16E-12SGTC_396dithiazanine 1.2 μMMiscellaneous105780.0519481
0.0912.44E-12SGTC_546peri-Naphthalide 147.0 μMChemDiv (Drug-like library)2238240.183673DNA damage response
0.0903.62E-12SGTC_200k038-0079 37.5 μMChemDiv (Drug-like library)34366830.0606061ubiquinone biosynthesis & proteasome

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_21425622915118.52 μM0.476195322196Chembridge (Fragment library)202.2062.63513
SGTC_1816st05195791.6 μM0.355556674121TimTec (Natural product derivative library)218.248463.26203
SGTC_1600coumarin 10671.1 μM0.352941100336TimTec (Pure natural product library)281.348964.10103
SGTC_1977st07072065.3 μM0.327273682188TimTec (Natural product derivative library)306.312064.30904
SGTC_25787,8-dihydroxyflavone64.44 μM0.281880Microsource (Natural product library)254.23752.65224
SGTC_18903',4',7',8'-tetrahydroxyflavone14.9 μM0.27451688798TimTec (Natural product derivative library)286.23632.16846
SGTC_7234182-0001115 μM0.269231744821ChemDiv (Drug-like library)218.248463.27203
SGTC_1892st0584117.36 μM0.2678573934738TimTec (Natural product derivative library)365.60584.99513
SGTC_22607964312200 μM0.265306231951Chembridge (Fragment library)213.2753.13502
SGTC_25534-methylesculetin85.09 μM0.260875319502Microsource (Natural product library)192.168121.86224