3558-0053

2,4-dichloro-5-[(2-methyl-5-morpholin-4-ylsulfonylphenyl)sulfamoyl]-N-phenylbenzamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1398
Screen concentration 112.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 4532369
SMILES CC1=C(C=C(C=C1)S(=O)(=O)N2CCOCC2)NS(=O)(=O)C3=C(C=C(C(=C3)C(=O)NC4=CC=CC=C4)Cl)Cl
Standardized SMILES Cc1ccc(cc1NS(=O)(=O)c2cc(C(=O)Nc3ccccc3)c(Cl)cc2Cl)S(=O)(=O)N4CCOCC4
Molecular weight 584.4919
ALogP 3.72
H-bond donor count 2
H-bond acceptor count 8
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.25
% growth inhibition (Hom. pool) 2.98


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4532369
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4532369
Download HOP data (tab-delimited text)  (excel)
Gene:ALE1(YOR175C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:BPT1(YLL015W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p Gene:BTS1(YPL069C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CRG1(YHR209W)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:DHH1(YDL160C)|FD-Score:4.79|P-value:8.54E-7||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:ECM33(YBR078W)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:EEB1(YPL095C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication Gene:EFT2(YDR385W)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:IRS4(YKR019C)|FD-Score:-3.39|P-value:3.53E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MEF1(YLR069C)|FD-Score:3.73|P-value:9.46E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:PHO89(YBR296C)|FD-Score:3.11|P-value:9.38E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:PSY4(YBL046W)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Gene:RPL36B(YPL249C-A)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication Gene:SMM1(YNR015W)|FD-Score:3.22|P-value:6.37E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:YAR029W(YAR029W_p)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YDR003W-A(YDR003W-A_p)|FD-Score:-3.27|P-value:5.36E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR161W(YDR161W_p)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:YEL010W(YEL010W_d)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YSC83(YHR017W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:ALE1(YOR175C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:BPT1(YLL015W)|FD-Score:3.2|P-value:6.87E-4||SGD DESC:ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p Gene:BTS1(YPL069C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CRG1(YHR209W)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:DHH1(YDL160C)|FD-Score:4.79|P-value:8.54E-7||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:ECM33(YBR078W)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:EEB1(YPL095C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication Gene:EFT2(YDR385W)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication Gene:HOP2(YGL033W)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:IRS4(YKR019C)|FD-Score:-3.39|P-value:3.53E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MEF1(YLR069C)|FD-Score:3.73|P-value:9.46E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:PHO89(YBR296C)|FD-Score:3.11|P-value:9.38E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:PSY4(YBL046W)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Gene:RPL36B(YPL249C-A)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication Gene:SMM1(YNR015W)|FD-Score:3.22|P-value:6.37E-4||SGD DESC:Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs Gene:YAR029W(YAR029W_p)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YDR003W-A(YDR003W-A_p)|FD-Score:-3.27|P-value:5.36E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR161W(YDR161W_p)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:YEL010W(YEL010W_d)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YSC83(YHR017W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKR079C2.850.002200.11TRZ1tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
YER012W2.840.002270.11PRE1Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YBR091C2.780.002730.11TIM12Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YGR172C2.670.003830.02YIP1Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
YBL050W2.640.004090.03SEC17Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
YPR019W2.610.004470.02MCM4Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
YML092C2.590.004770.03PRE8Alpha 2 subunit of the 20S proteasome
YLR339C_d2.560.005180.05YLR339C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YML130C2.510.005970.00ERO1Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
YLR088W2.510.005990.09GAA1Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
YHL015W2.430.007650.02RPS20Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
YGR278W2.410.008040.04CWC22Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
YOL069W2.370.008970.01NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YCR012W2.360.009170.03PGK13-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YLR223C2.330.009860.10IFH1Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL160C4.798.54E-7DHH1Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
YBR078W3.973.52E-5ECM33GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YLR069C3.739.46E-5MEF1Mitochondrial elongation factor involved in translational elongation
YEL010W_d3.561.87E-4YEL010W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR161W_p3.512.25E-4YDR161W_pPutative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
YAR029W_p3.492.44E-4YAR029W_pMember of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR385W3.472.57E-4EFT2Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
YGL033W3.423.17E-4HOP2Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YPL069C3.363.92E-4BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YBL046W3.295.08E-4PSY4Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
YNR015W3.226.37E-4SMM1Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YLL015W3.206.87E-4BPT1ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
YPL249C-A3.187.47E-4RPL36BRibosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
YHR209W3.177.62E-4CRG1S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
YPL095C3.138.82E-4EEB1Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1398
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1096.20E-17SGTC_2489cantharidin 73.4 μMICCB bioactive library25450.0666667cell wall signaling
0.1011.00E-14SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.139535
0.1001.43E-14SGTC_1752st044819 83.0 μMTimTec (Natural product derivative library)4412090.1
0.0921.55E-12SGTC_2415hr heat shock (37°C) + cantharidin 155.4 μMICCB bioactive library25450.0666667cell wall signaling
0.0921.43E-12SGTC_287k060-0039 29.6 μMChemDiv (Drug-like library)58619740.11236
0.0913.38E-12SGTC_32429133940 49.5 μMChembridge (Drug-like library)172484440.105263
0.0806.86E-10SGTC_6941315-0438 43.2 μMChemDiv (Drug-like library)67931540.108911
0.0772.92E-9SGTC_1764st044502 93.5 μMTimTec (Natural product derivative library)84070.150685
0.0732.04E-8SGTC_24875918373 44.0 μMMiscellaneous28762790.126316
0.0732.20E-8SGTC_1806st050005 60.3 μMTimTec (Natural product derivative library)51947650.0888889
0.0732.48E-8SGTC_482fipronil 114.0 μMICCB bioactive library33520.0736842
0.0715.65E-8SGTC_1841494-0393 24.7 μMChemDiv (Drug-like library)30906470.142857
0.0706.09E-8SGTC_1692fluoroquinolonic acid 71.0 μMTimTec (Natural product derivative library)4831800.125
0.0707.25E-8SGTC_485niflumic acid 177.0 μMMiscellaneous44880.139535
0.0708.20E-8SGTC_2961222-0039 74.9 μMChemDiv (Drug-like library)59841760.0843373

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2892904735858.44 μM0.3513516466771Chembridge (Drug-like library)379.861122.414
SGTC_2794778538227.27 μM0.3421052205081Chembridge (Drug-like library)396.45953.57225
SGTC_3086911735049.47 μM0.3205132679265Chembridge (Drug-like library)365.3760432.27207
SGTC_3285911281820.87 μM0.31707317017947Chembridge (Drug-like library)408.899043.29615cell wall
SGTC_2992907459171.43 μM0.31645617741321Chembridge (Drug-like library)374.453981.91215
SGTC_2802792581554.55 μM0.3086421262923Chembridge (Drug-like library)394.872463.07125
SGTC_12580671-004357.1 μM0.3055564298767ChemDiv (Drug-like library)296.772522.72124
SGTC_3133912773649.47 μM0.2790727243420Chembridge (Drug-like library)392.4444432.86426
SGTC_3203911354349.47 μM0.27777817018012Chembridge (Drug-like library)241.28513.08412
SGTC_2942905277762.25 μM0.2739736469503Chembridge (Drug-like library)284.1131234.14912