3771-8998

N-(1,3-benzodioxol-5-ylmethyl)-2-ethoxybenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1400
Screen concentration 51.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 670767
SMILES CCOC1=CC=CC=C1C(=O)NCC2=CC3=C(C=C2)OCO3
Standardized SMILES CCOc1ccccc1C(=O)NCc2ccc3OCOc3c2
Molecular weight 299.3212
ALogP 2.72
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.45
% growth inhibition (Hom. pool) 4.21


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 670767
Download HIP data (tab-delimited text)  (excel)
Gene:PRE1(YER012W)|FD-Score:3.82|P-value:6.63E-5|Clearance:0.99||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:SEC13(YLR208W)|FD-Score:4.67|P-value:1.51E-6|Clearance:0.99||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:TUB1(YML085C)|FD-Score:3.77|P-value:8.13E-5|Clearance:0.99||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication Gene:PRE1(YER012W)|FD-Score:3.82|P-value:6.63E-5|Clearance:0.99||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:SEC13(YLR208W)|FD-Score:4.67|P-value:1.51E-6|Clearance:0.99||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:TUB1(YML085C)|FD-Score:3.77|P-value:8.13E-5|Clearance:0.99||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 670767
Download HOP data (tab-delimited text)  (excel)
Gene:ALK1(YGL021W)|FD-Score:-3.53|P-value:2.08E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ATG31(YDR022C)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion Gene:CCM1(YGR150C)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport Gene:COG7(YGL005C)|FD-Score:4.08|P-value:2.24E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX10(YPL172C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:DIC1(YLR348C)|FD-Score:-3.25|P-value:5.80E-4||SGD DESC:Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix Gene:ENT2(YLR206W)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Gene:FAR3(YMR052W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:GAL4(YPL248C)|FD-Score:-3.15|P-value:8.04E-4||SGD DESC:DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Gene:GCS1(YDL226C)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:HXT10(YFL011W)|FD-Score:4.41|P-value:5.16E-6||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:LAS21(YJL062W)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MBF1(YOR298C-A)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress Gene:MEU1(YLR017W)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression Gene:MNL1(YHR204W)|FD-Score:4.47|P-value:3.86E-6||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:NAT1(YDL040C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NIP100(YPL174C)|FD-Score:4.6|P-value:2.15E-6||SGD DESC:Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) Gene:NRP1(YDL167C)|FD-Score:3.41|P-value:3.19E-4||SGD DESC:Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis Gene:NRT1(YOR071C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity Gene:NTG2(YOL043C)|FD-Score:4.52|P-value:3.12E-6||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OCA2(YNL056W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:PDA1(YER178W)|FD-Score:-3.28|P-value:5.25E-4||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:REF2(YDR195W)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes Gene:RGI2(YIL057C)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose Gene:SRO9(YCL037C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:TOS2(YGR221C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p Gene:URA7(YBL039C)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:VPS5(YOR069W)|FD-Score:4.11|P-value:1.99E-5||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:WWM1(YFL010C)|FD-Score:5.68|P-value:6.74E-9||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YBR062C(YBR062C_p)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. Gene:YBR206W(YBR206W_d)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YFL041W-A(YFL041W-A_p)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGL262W(YGL262W_p)|FD-Score:-3.77|P-value:8.08E-5||SGD DESC:Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene Gene:YML122C(YML122C_d)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL057W(YOL057W)|FD-Score:3.53|P-value:2.12E-4||SGD DESC:Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers Gene:YOR1(YGR281W)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) Gene:YPR012W(YPR012W_d)|FD-Score:3.78|P-value:7.99E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Gene:ALK1(YGL021W)|FD-Score:-3.53|P-value:2.08E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ATG31(YDR022C)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion Gene:CCM1(YGR150C)|FD-Score:4.22|P-value:1.23E-5||SGD DESC:Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport Gene:COG7(YGL005C)|FD-Score:4.08|P-value:2.24E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX10(YPL172C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:DIC1(YLR348C)|FD-Score:-3.25|P-value:5.80E-4||SGD DESC:Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix Gene:ENT2(YLR206W)|FD-Score:-3.41|P-value:3.30E-4||SGD DESC:Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Gene:FAR3(YMR052W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:GAL4(YPL248C)|FD-Score:-3.15|P-value:8.04E-4||SGD DESC:DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Gene:GCS1(YDL226C)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:HXT10(YFL011W)|FD-Score:4.41|P-value:5.16E-6||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:LAS21(YJL062W)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MBF1(YOR298C-A)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress Gene:MEU1(YLR017W)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression Gene:MNL1(YHR204W)|FD-Score:4.47|P-value:3.86E-6||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:NAT1(YDL040C)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NIP100(YPL174C)|FD-Score:4.6|P-value:2.15E-6||SGD DESC:Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) Gene:NRP1(YDL167C)|FD-Score:3.41|P-value:3.19E-4||SGD DESC:Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis Gene:NRT1(YOR071C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity Gene:NTG2(YOL043C)|FD-Score:4.52|P-value:3.12E-6||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication Gene:OCA2(YNL056W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene Gene:PDA1(YER178W)|FD-Score:-3.28|P-value:5.25E-4||SGD DESC:E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose Gene:REF2(YDR195W)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes Gene:RGI2(YIL057C)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose Gene:SRO9(YCL037C)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication Gene:TOS2(YGR221C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p Gene:URA7(YBL039C)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:VPS5(YOR069W)|FD-Score:4.11|P-value:1.99E-5||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:WWM1(YFL010C)|FD-Score:5.68|P-value:6.74E-9||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:YBR062C(YBR062C_p)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. Gene:YBR206W(YBR206W_d)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YFL041W-A(YFL041W-A_p)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGL262W(YGL262W_p)|FD-Score:-3.77|P-value:8.08E-5||SGD DESC:Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene Gene:YML122C(YML122C_d)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOL057W(YOL057W)|FD-Score:3.53|P-value:2.12E-4||SGD DESC:Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers Gene:YOR1(YGR281W)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) Gene:YPR012W(YPR012W_d)|FD-Score:3.78|P-value:7.99E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR208W4.671.51E-60.99SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YER012W3.826.63E-50.99PRE1Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YML085C3.778.13E-50.99TUB1Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
YBR140C2.780.002730.11IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YDR047W2.670.003810.22HEM12Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YER021W2.450.007210.00RPN3Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YOR261C2.450.007230.11RPN8Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
YMR309C2.340.009750.16NIP1eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YPL218W2.170.014900.01SAR1GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
YPR176C2.160.015300.03BET2Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YJR013W2.140.016300.00GPI14Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
YNL137C2.130.016400.06NAM9Mitochondrial ribosomal component of the small subunit
YGL008C2.080.019000.00PMA1Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
YBL105C2.070.019200.03PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YGL048C2.040.020800.04RPT6ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFL010C5.686.74E-9WWM1WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YPL174C4.602.15E-6NIP100Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
YOL043C4.523.12E-6NTG2DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
YHR204W4.473.86E-6MNL1Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
YFL011W4.415.16E-6HXT10Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YGR150C4.221.23E-5CCM1Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
YOR069W4.111.99E-5VPS5Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
YGL005C4.082.24E-5COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YJL062W4.022.87E-5LAS21Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
YOR298C-A3.914.63E-5MBF1Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
YDR022C3.787.69E-5ATG31Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YPR012W_d3.787.99E-5YPR012W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
YCL037C3.661.28E-4SRO9Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
YOR071C3.611.53E-4NRT1High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YMR052W3.551.90E-4FAR3Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_1400
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1521.23E-31SGTC_20255147754 141.0 μMChembridge (Fragment library)3157770.181818
0.1292.44E-23SGTC_14204'-methoxyflavone 42.0 μMChemDiv (Drug-like library)777930.149254
0.1262.54E-22SGTC_32009114385 49.5 μMChembridge (Drug-like library)170180300.19403
0.1263.02E-22SGTC_1743st037606 46.4 μMTimTec (Natural product derivative library)5901420.105263
0.1219.19E-21SGTC_2902043-6722 48.1 μMChemDiv (Drug-like library)7737580.121622
0.1201.98E-20SGTC_7864544-0069 423.0 μMChemDiv (Drug-like library)7488210.151515
0.1159.50E-19SGTC_14163966-0321 25.3 μMChemDiv (Drug-like library)5825300.125
0.1049.48E-16SGTC_30959117207 49.5 μMChembridge (Drug-like library)170152290.153846
0.1032.14E-15SGTC_9933909-8757 62.7 μMChemDiv (Drug-like library)42883240.109589
0.0946.13E-13SGTC_1655st012546 55.1 μMTimTec (Natural product derivative library)7209850.132353
0.0937.04E-13SGTC_1168k815-0004 80.5 μMChemDiv (Drug-like library)6424330.0857143DNA damage response
0.0903.93E-12SGTC_592k241-0073 46.5 μMChemDiv (Drug-like library)42301580.0547945
0.0863.45E-11SGTC_1751st044839 27.2 μMTimTec (Natural product derivative library)52913260.153846Golgi
0.0855.85E-11SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.174603Golgi
0.0857.84E-11SGTC_31979113331 49.5 μMChembridge (Drug-like library)166104590.116279

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3166910229749.47 μM0.425237072Chembridge (Drug-like library)348.191263.15513Golgi
SGTC_2825799809458.44 μM0.3970592987815Chembridge (Drug-like library)418.506543.07407fatty acid desaturase (OLE1)
SGTC_3039909027049.47 μM0.39655217173750Chembridge (Drug-like library)303.740263.07113RPP1 & pyrimidine depletion
SGTC_3089911742549.47 μM0.3833339401657Chembridge (Drug-like library)297.348363.81613
SGTC_1661st0130639.66 μM0.360656721395TimTec (Natural product derivative library)262.257961.9605
SGTC_1652st01193278 μM0.3492061551076TimTec (Natural product derivative library)245.230742.10905RSC complex & mRNA processing
SGTC_23559061122103.12 μM0.3454555302957Chembridge (Fragment library)215.247822.07312
SGTC_5313788-1495174 μM0.343752896655ChemDiv (Drug-like library)299.321182.37814unfolded protein response
SGTC_2848901637025.97 μM0.3382357894410Chembridge (Drug-like library)353.411623.50404
SGTC_3085911737649.47 μM0.33823516480349Chembridge (Drug-like library)331.3382233.44915