Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOL120C | 5.49 | 1.96E-8 | 0.46 | RPL18A | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication |
YOR294W | 5.20 | 1.02E-7 | 0.46 | RRS1 | Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice |
YER148W | 4.91 | 4.55E-7 | 0.46 | SPT15 | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
YDR362C | 4.72 | 1.19E-6 | 0.46 | TFC6 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 |
YER003C | 4.65 | 1.67E-6 | 0.46 | PMI40 | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |
YGR095C | 4.49 | 3.58E-6 | 0.46 | RRP46 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) |
YMR208W | 4.43 | 4.82E-6 | 0.46 | ERG12 | Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YOR278W | 4.37 | 6.11E-6 | 0.46 | HEM4 | Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria |
YGR156W | 4.36 | 6.54E-6 | 0.46 | PTI1 | Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 |
YHR172W | 4.19 | 1.39E-5 | 0.46 | SPC97 | Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque |
YNL317W | 3.73 | 9.57E-5 | 0.11 | PFS2 | Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex |
YMR168C | 3.62 | 1.49E-4 | 0.17 | CEP3 | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
YJL025W | 3.45 | 2.81E-4 | 0.04 | RRN7 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YDL058W | 3.40 | 3.31E-4 | 0.15 | USO1 | Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex |
YFL039C | 3.25 | 5.69E-4 | 0.03 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |