Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR208W | 25.50 | 3.16E-144 | 20.00 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YER148W | 5.59 | 1.15E-8 | 1.05 | SPT15 | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
YKL145W | 4.54 | 2.78E-6 | 0.46 | RPT1 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance |
YDL195W | 4.09 | 2.18E-5 | 0.19 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YOR340C | 3.90 | 4.78E-5 | 0.16 | RPA43 | RNA polymerase I subunit A43 |
YBR257W | 3.74 | 9.23E-5 | 0.10 | POP4 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
YOL123W | 3.64 | 1.37E-4 | 0.09 | HRP1 | Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences |
YOR116C | 3.55 | 1.96E-4 | 0.04 | RPO31 | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
YLL037W_d | 3.51 | 2.24E-4 | 0.02 | YLL037W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor |
YOR149C | 3.49 | 2.39E-4 | 0.21 | SMP3 | Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure |
YOR224C | 3.29 | 5.09E-4 | 0.04 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YFL017W-A | 3.24 | 5.91E-4 | 0.23 | SMX2 | Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G |
YML092C | 3.02 | 0.00128 | 0.05 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YER009W | 2.97 | 0.00151 | 0.07 | NTF2 | Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport |
YPR183W | 2.90 | 0.00187 | 0.00 | DPM1 | Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation |