Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR134W | 8.82 | 5.54E-19 | CAF130 | Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation |
YDR174W | 7.35 | 9.84E-14 | HMO1 | Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase |
YHR193C | 6.68 | 1.17E-11 | EGD2 | Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes |
YJR048W | 6.53 | 3.28E-11 | CYC1 | Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication |
YER074W | 5.90 | 1.81E-9 | RPS24A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication |
YHR039C | 5.59 | 1.14E-8 | MSC7 | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
YAL012W | 5.41 | 3.14E-8 | CYS3 | Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress |
YER117W | 5.38 | 3.80E-8 | RPL23B | Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication |
YKL181W | 4.86 | 5.76E-7 | PRS1 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
YPR061C | 4.80 | 7.87E-7 | JID1 | Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae |
YLR111W_d | 4.64 | 1.71E-6 | YLR111W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YGL026C | 4.55 | 2.71E-6 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YOR225W_d | 4.47 | 3.97E-6 | YOR225W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOL131W_p | 4.46 | 4.07E-6 | YOL131W_p | Putative protein of unknown function |
YER139C | 4.43 | 4.76E-6 | RTR1 | CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication |