Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL126W | 7.29 | 1.59E-13 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
YDR174W | 6.60 | 2.03E-11 | HMO1 | Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase |
YOL076W | 6.26 | 1.96E-10 | MDM20 | Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly |
YPL053C | 5.64 | 8.45E-9 | KTR6 | Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication |
YGR250C | 5.62 | 9.76E-9 | YGR250C | Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress |
YNL154C | 5.01 | 2.75E-7 | YCK2 | Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication |
YKL181W | 4.86 | 5.80E-7 | PRS1 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
YLR052W | 4.65 | 1.66E-6 | IES3 | Subunit of the INO80 chromatin remodeling complex |
YPL183W-A | 4.61 | 1.98E-6 | RTC6 | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
YLR413W_p | 4.44 | 4.57E-6 | YLR413W_p | Putative protein of unknown function; YLR413W is not an essential gene |
YGR256W | 4.38 | 5.97E-6 | GND2 | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication |
YMR263W | 4.28 | 9.37E-6 | SAP30 | Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance |
YLR031W_p | 4.26 | 1.03E-5 | YLR031W_p | Putative protein of unknown function |
YBR129C | 4.22 | 1.21E-5 | OPY1 | Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YFR035C_p | 4.12 | 1.90E-5 | YFR035C_p | Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein |