4092-1045

1-(2-adamantyl)-4-(4-methylcyclohexyl)piperazine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1438
Screen concentration 4.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 1351342
SMILES CC1CCC(CC1)N2CCN(CC2)C3C4CC5CC(C4)CC3C5
Standardized SMILES CC1CCC(CC1)N2CCN(CC2)C3C4CC5CC(CC3C5)C4
Molecular weight 316.5239
ALogP 4.64
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 1
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1351342
Download HIP data (tab-delimited text)  (excel)
Gene:ARP4(YJL081C)|FD-Score:-3.09|P-value:9.86E-4|Clearance:0||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:ASA1(YPR085C)|FD-Score:3.35|P-value:4.06E-4|Clearance:0.05||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:BRR6(YGL247W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.09||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:CDC123(YLR215C)|FD-Score:-3.24|P-value:6.02E-4|Clearance:0||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:CDC31(YOR257W)|FD-Score:-3.1|P-value:9.75E-4|Clearance:0||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:FAP7(YDL166C)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.26||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:NOG2(YNR053C)|FD-Score:3.2|P-value:6.81E-4|Clearance:0.04||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUP85(YJR042W)|FD-Score:-3.11|P-value:9.45E-4|Clearance:0||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:RIM2(YBR192W)|FD-Score:-3.74|P-value:9.17E-5|Clearance:0||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPL18A(YOL120C)|FD-Score:3.16|P-value:7.76E-4|Clearance:0.06||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RPN7(YPR108W)|FD-Score:3.1|P-value:9.54E-4|Clearance:0.05||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits Gene:RPS31(YLR167W)|FD-Score:4.65|P-value:1.68E-6|Clearance:0.66||SGD DESC:Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog Gene:TIF11(YMR260C)|FD-Score:5.34|P-value:4.67E-8|Clearance:0.69||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:URB1(YKL014C)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:VRG4(YGL225W)|FD-Score:3.81|P-value:7.04E-5|Clearance:0.2||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YNL114C(YNL114C_d)|FD-Score:3.99|P-value:3.27E-5|Clearance:0.19||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Gene:ARP4(YJL081C)|FD-Score:-3.09|P-value:9.86E-4|Clearance:0||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:ASA1(YPR085C)|FD-Score:3.35|P-value:4.06E-4|Clearance:0.05||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:BRR6(YGL247W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.09||SGD DESC:Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism Gene:CDC123(YLR215C)|FD-Score:-3.24|P-value:6.02E-4|Clearance:0||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:CDC31(YOR257W)|FD-Score:-3.1|P-value:9.75E-4|Clearance:0||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:FAP7(YDL166C)|FD-Score:3.61|P-value:1.54E-4|Clearance:0.26||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:NOG2(YNR053C)|FD-Score:3.2|P-value:6.81E-4|Clearance:0.04||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUP85(YJR042W)|FD-Score:-3.11|P-value:9.45E-4|Clearance:0||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:RIM2(YBR192W)|FD-Score:-3.74|P-value:9.17E-5|Clearance:0||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPL18A(YOL120C)|FD-Score:3.16|P-value:7.76E-4|Clearance:0.06||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RPN7(YPR108W)|FD-Score:3.1|P-value:9.54E-4|Clearance:0.05||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits Gene:RPS31(YLR167W)|FD-Score:4.65|P-value:1.68E-6|Clearance:0.66||SGD DESC:Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog Gene:TIF11(YMR260C)|FD-Score:5.34|P-value:4.67E-8|Clearance:0.69||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:URB1(YKL014C)|FD-Score:-3.43|P-value:3.07E-4|Clearance:0||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:VRG4(YGL225W)|FD-Score:3.81|P-value:7.04E-5|Clearance:0.2||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YNL114C(YNL114C_d)|FD-Score:3.99|P-value:3.27E-5|Clearance:0.19||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1351342
Download HOP data (tab-delimited text)  (excel)
Gene:BST1(YFL025C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:COA1(YIL157C)|FD-Score:5.07|P-value:1.99E-7||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:CYC7(YEL039C)|FD-Score:4.03|P-value:2.74E-5||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DBP3(YGL078C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EFG1(YGR271C-A)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FEN1(YCR034W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication Gene:HHF1(YBR009C)|FD-Score:4.38|P-value:6.01E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HTA1(YDR225W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:IZH1(YDR492W)|FD-Score:-4.69|P-value:1.35E-6||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:LCB3(YJL134W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:LSB6(YJL100W)|FD-Score:3.1|P-value:9.60E-4||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:NAM7(YMR080C)|FD-Score:3.22|P-value:6.31E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:OPT2(YPR194C)|FD-Score:3.73|P-value:9.47E-5||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PSD2(YGR170W)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine Gene:RHO4(YKR055W)|FD-Score:3.53|P-value:2.04E-4||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity Gene:RPS11B(YBR048W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RPS30A(YLR287C-A)|FD-Score:4.14|P-value:1.76E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication Gene:RPS7B(YNL096C)|FD-Score:3.23|P-value:6.25E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SCP1(YOR367W)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin Gene:SLX9(YGR081C)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant Gene:SNX4(YJL036W)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SRC1(YML034W)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:STE20(YHL007C)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:SUS1(YBR111W-A)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP Gene:TDH1(YJL052W)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:THP2(YHR167W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UBP15(YMR304W)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:YBR056W-A(YBR056W-A_p)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B Gene:YBR174C(YBR174C_d)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Gene:YGL034C(YGL034C_d)|FD-Score:4.39|P-value:5.65E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL088W(YGL088W_d)|FD-Score:3.72|P-value:9.83E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Gene:YGR273C(YGR273C_p)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YHL026C(YHL026C_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YHR086W-A(YHR086W-A_p)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YML012C-A(YML012C-A_d)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Gene:YSC83(YHR017W)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:BST1(YFL025C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:COA1(YIL157C)|FD-Score:5.07|P-value:1.99E-7||SGD DESC:Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly Gene:CYC7(YEL039C)|FD-Score:4.03|P-value:2.74E-5||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DBP3(YGL078C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:EFG1(YGR271C-A)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FEN1(YCR034W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication Gene:HHF1(YBR009C)|FD-Score:4.38|P-value:6.01E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HTA1(YDR225W)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:IZH1(YDR492W)|FD-Score:-4.69|P-value:1.35E-6||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:LCB3(YJL134W)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication Gene:LSB6(YJL100W)|FD-Score:3.1|P-value:9.60E-4||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:NAM7(YMR080C)|FD-Score:3.22|P-value:6.31E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:OPT2(YPR194C)|FD-Score:3.73|P-value:9.47E-5||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PSD2(YGR170W)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine Gene:RHO4(YKR055W)|FD-Score:3.53|P-value:2.04E-4||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity Gene:RPS11B(YBR048W)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RPS30A(YLR287C-A)|FD-Score:4.14|P-value:1.76E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication Gene:RPS7B(YNL096C)|FD-Score:3.23|P-value:6.25E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SCP1(YOR367W)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin Gene:SLX9(YGR081C)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant Gene:SNX4(YJL036W)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SRC1(YML034W)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:STE20(YHL007C)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:SUS1(YBR111W-A)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP Gene:TDH1(YJL052W)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress Gene:THP2(YHR167W)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:UBP15(YMR304W)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:YBR056W-A(YBR056W-A_p)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B Gene:YBR174C(YBR174C_d)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Gene:YGL034C(YGL034C_d)|FD-Score:4.39|P-value:5.65E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL088W(YGL088W_d)|FD-Score:3.72|P-value:9.83E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Gene:YGR273C(YGR273C_p)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YHL026C(YHL026C_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YHR086W-A(YHR086W-A_p)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YML012C-A(YML012C-A_d)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Gene:YSC83(YHR017W)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR260C5.344.67E-80.69TIF11Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
YLR167W4.651.68E-60.66RPS31Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
YNL114C_d3.993.27E-50.18YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YGL225W3.817.04E-50.20VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YDL166C3.611.54E-40.26FAP7Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YPR085C3.354.06E-40.06ASA1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
YGL247W3.294.94E-40.09BRR6Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
YNR053C3.206.81E-40.04NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YOL120C3.167.76E-40.06RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YPR108W3.109.54E-40.05RPN7Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
YKR022C3.050.001140.13NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YNL061W2.920.001740.01NOP2Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YKR004C2.920.001770.02ECM9Non-essential protein of unknown function
YHR024C2.890.001910.04MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YJL041W2.860.002150.15NSP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL157C5.071.99E-7COA1Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly
YHR017W4.454.28E-6YSC83Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YGL034C_d4.395.65E-6YGL034C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR009C4.386.01E-6HHF1Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YLR287C-A4.141.76E-5RPS30AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
YHR086W-A_p4.062.47E-5YHR086W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YEL039C4.032.74E-5CYC7Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication
YPR194C3.739.47E-5OPT2Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
YGL088W_d3.729.83E-5YGL088W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YJL134W3.681.15E-4LCB3Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
YDR225W3.661.25E-4HTA1Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YHL026C_p3.651.29E-4YHL026C_pPutative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YGL078C3.561.84E-4DBP3RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
YKR055W3.532.04E-4RHO4Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YBR056W-A_p3.413.22E-4YBR056W-A_pProtein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B

GO enrichment analysis for SGTC_1438
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0823.53E-10SGTC_2970986-0032 24.0 μMChemDiv (Drug-like library)28474250.016666760S ribosome export
0.0773.92E-9SGTC_30669117245 49.5 μMChembridge (Drug-like library)171769800.0615385
0.0682.04E-7SGTC_14414106-0040 13.0 μMChemDiv (Drug-like library)29041800.046875
0.0673.05E-7SGTC_485niflumic acid 177.0 μMMiscellaneous4488NA
0.0648.57E-7SGTC_810411-0046 10.0 μMChemDiv (Drug-like library)129252650.0185185
0.0641.04E-6SGTC_14424112-3290 3.0 μMChemDiv (Drug-like library)7043530.015873
0.0631.49E-6SGTC_2723salbutamol 83.6 μMNIH Clinical Collection98842330.0172414
0.0621.74E-6SGTC_5651418-0001 44.5 μMChemDiv (Drug-like library)28621450.0172414
0.0613.06E-6SGTC_14364092-1007 8.3 μMChemDiv (Drug-like library)28811210.0847458
0.0587.71E-6SGTC_25742',4'-dihydroxychalcone 14.6 μMTimTec (Pure natural product library)5357218NA
0.0561.57E-5SGTC_30299088683 49.5 μMChembridge (Drug-like library)252366150.0655738
0.0552.55E-5SGTC_1578josamycin 24.2 μMTimTec (Pure natural product library)52821650.0416667
0.0543.87E-5SGTC_2730imipramine 71.3 μMMiscellaneous36960.0576923
0.0526.31E-5SGTC_4283448-4153 16.5 μMChemDiv (Drug-like library)38348740.0526316TSC3-RPN4
0.0526.53E-5SGTC_5660958-0068 16.5 μMChemDiv (Drug-like library)6815365NARSC & ERG11

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_14374092-103811.6 μM0.6666673977136ChemDiv (Drug-like library)316.523944.64402
SGTC_2014262-015912.8 μM0.3809521341029ChemDiv (Drug-like library)300.481484.91302ergosterol depletion effects on membrane
SGTC_14754092-104811.7 μM0.3260872881759ChemDiv (Drug-like library)338.529465.02102plasma membrane duress
SGTC_10054092-06904.4 μM0.2222221529343ChemDiv (Drug-like library)364.523684.98603plasma membrane duress
SGTC_6464092-083927.3 μM0.212766877796ChemDiv (Drug-like library)306.873384.83902plasma membrane duress
SGTC_10194262-02123.4 μM0.2115384677213ChemDiv (Drug-like library)352.4881635.20803ergosterol depletion effects on membrane
SGTC_2641levomentholum100 μM0.20512816666Microsource (Natural product library)156.26522.77911
SGTC_3124092-06536.84 μM0.2037041148278ChemDiv (Drug-like library)366.4716834.54903ergosterol depletion effects on membrane
SGTC_3204092-08465.34 μM0.203391359356ChemDiv (Drug-like library)394.549664.9704ergosterol depletion effects on membrane
SGTC_11564092-03674.88 μM0.1929821357585ChemDiv (Drug-like library)382.926285.00702