4100-1550

(E)-3-(1,3-benzodioxol-5-yl)-N-pyridin-2-ylprop-2-enamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1440
Screen concentration 40.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 742806
SMILES C1OC2=C(O1)C=C(C=C2)C=CC(=O)NC3=CC=CC=N3
Standardized SMILES O=C(Nc1ccccn1)C=Cc2ccc3OCOc3c2
Molecular weight 268.2674
ALogP 2.24
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.07
% growth inhibition (Hom. pool) 1.18


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 742806
Download HIP data (tab-delimited text)  (excel)
Gene:ARC35(YNR035C)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.23||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:RPN6(YDL097C)|FD-Score:3.22|P-value:6.44E-4|Clearance:0.23||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress Gene:SHR3(YDL212W)|FD-Score:3.52|P-value:2.13E-4|Clearance:0.23||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:YCL041C(YCL041C_d)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W Gene:YIF1(YNL263C)|FD-Score:3.67|P-value:1.23E-4|Clearance:0.23||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 Gene:ARC35(YNR035C)|FD-Score:3.42|P-value:3.12E-4|Clearance:0.23||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:RPN6(YDL097C)|FD-Score:3.22|P-value:6.44E-4|Clearance:0.23||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress Gene:SHR3(YDL212W)|FD-Score:3.52|P-value:2.13E-4|Clearance:0.23||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:YCL041C(YCL041C_d)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W Gene:YIF1(YNL263C)|FD-Score:3.67|P-value:1.23E-4|Clearance:0.23||SGD DESC:Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 742806
Download HOP data (tab-delimited text)  (excel)
Gene:CHS5(YLR330W)|FD-Score:3.26|P-value:5.49E-4||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:DAT1(YML113W)|FD-Score:-3.74|P-value:9.30E-5||SGD DESC:DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability Gene:GNP1(YDR508C)|FD-Score:-4.04|P-value:2.62E-5||SGD DESC:High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication Gene:GOR1(YNL274C)|FD-Score:-3.12|P-value:9.08E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:IDH2(YOR136W)|FD-Score:4.47|P-value:3.96E-6||SGD DESC:Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated Gene:NAB6(YML117W)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:NGL3(YML118W)|FD-Score:-3.58|P-value:1.69E-4||SGD DESC:3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication Gene:PEP8(YJL053W)|FD-Score:3.76|P-value:8.39E-5||SGD DESC:Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress Gene:RCF1(YML030W)|FD-Score:4|P-value:3.15E-5||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RPS9B(YBR189W)|FD-Score:3.25|P-value:5.87E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication Gene:RRF1(YHR038W)|FD-Score:4.82|P-value:7.30E-7||SGD DESC:Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria Gene:RRG1(YDR065W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAM2(YDR502C)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SPO22(YIL073C)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis Gene:STP3(YLR375W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids Gene:TEF2(YBR118W)|FD-Score:-3.34|P-value:4.11E-4||SGD DESC:Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication Gene:TMA23(YMR269W)|FD-Score:3.92|P-value:4.48E-5||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:TPM2(YIL138C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:YBR242W(YBR242W_p)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YCL075W(YCL075W)|FD-Score:-3.41|P-value:3.21E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDL183C(YDL183C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YFL042C(YFL042C_p)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YMR193C-A(YMR193C-A_d)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:CHS5(YLR330W)|FD-Score:3.26|P-value:5.49E-4||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:DAT1(YML113W)|FD-Score:-3.74|P-value:9.30E-5||SGD DESC:DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability Gene:GNP1(YDR508C)|FD-Score:-4.04|P-value:2.62E-5||SGD DESC:High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication Gene:GOR1(YNL274C)|FD-Score:-3.12|P-value:9.08E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:IDH2(YOR136W)|FD-Score:4.47|P-value:3.96E-6||SGD DESC:Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated Gene:NAB6(YML117W)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:NGL3(YML118W)|FD-Score:-3.58|P-value:1.69E-4||SGD DESC:3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication Gene:PEP8(YJL053W)|FD-Score:3.76|P-value:8.39E-5||SGD DESC:Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress Gene:RCF1(YML030W)|FD-Score:4|P-value:3.15E-5||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RPS9B(YBR189W)|FD-Score:3.25|P-value:5.87E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication Gene:RRF1(YHR038W)|FD-Score:4.82|P-value:7.30E-7||SGD DESC:Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria Gene:RRG1(YDR065W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:SAM2(YDR502C)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SPO22(YIL073C)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis Gene:STP3(YLR375W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids Gene:TEF2(YBR118W)|FD-Score:-3.34|P-value:4.11E-4||SGD DESC:Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication Gene:TMA23(YMR269W)|FD-Score:3.92|P-value:4.48E-5||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:TPM2(YIL138C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:YBR242W(YBR242W_p)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YCL075W(YCL075W)|FD-Score:-3.41|P-value:3.21E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDL183C(YDL183C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene Gene:YFL042C(YFL042C_p)|FD-Score:-3.26|P-value:5.65E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YMR193C-A(YMR193C-A_d)|FD-Score:3.15|P-value:8.18E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL263C3.671.23E-40.23YIF1Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
YDL212W3.522.13E-40.23SHR3Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YNR035C3.423.12E-40.23ARC35Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
YDL097C3.226.44E-40.23RPN6Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
YKL104C3.090.001000.23GFA1Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
YDR064W2.860.002120.04RPS13Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
YDL015C2.820.002390.05TSC13Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
YOR282W_d2.780.002750.02YOR282W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
YDR145W2.750.002940.06TAF12Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YOR336W2.700.003490.10KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YDR170C2.590.004760.02SEC7Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YMR227C2.570.005080.00TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YKL172W2.570.005100.00EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YDR464W2.570.005120.04SPP41Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
YNR026C2.530.005760.02SEC12Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YHR038W4.827.30E-7RRF1Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YOR136W4.473.96E-6IDH2Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
YML030W4.003.15E-5RCF1Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
YMR269W3.924.48E-5TMA23Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
YJL053W3.768.39E-5PEP8Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
YIL073C3.462.67E-4SPO22Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis
YLR375W3.462.70E-4STP3Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YDR065W3.442.93E-4RRG1Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL183C3.363.94E-4YDL183CMitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
YBR242W_p3.294.93E-4YBR242W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YLR330W3.265.49E-4CHS5Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
YBR189W3.255.87E-4RPS9BProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
YMR193C-A_d3.158.18E-4YMR193C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL242C_p3.080.00104YGL242C_pPutative protein of unknown function; deletion mutant is viable
YNL001W3.070.00106DOM34Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication

GO enrichment analysis for SGTC_1440
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0903.41E-12SGTC_14063909-7906 11.9 μMChemDiv (Drug-like library)X14060.092105360S ribosome export
0.0631.34E-6SGTC_1518st038567 90.8 μMTimTec (Pure natural product library)779660.09375
0.0622.16E-6SGTC_14153966-0071 78.1 μMChemDiv (Drug-like library)28931850.133333DNA intercalators
0.0571.12E-5SGTC_511blebbistatin 171.0 μMICCB bioactive library34769860.118421DNA intercalators
0.0543.16E-5SGTC_2630antimycin a 100.0 μMMicrosource (Natural product library)57021990.1mitochondrial processes
0.0518.18E-5SGTC_1771st048882 4.2 μMTimTec (Natural product derivative library)45804030.115385RPP1 & pyrimidine depletion
0.0511.03E-4SGTC_1070358-0022 2.7 μMChemDiv (Drug-like library)5211060.0847458SWF1 & branched chain AA biosynthesis
0.0501.13E-4SGTC_2697mebhydrolin 72.4 μMTimTec (Natural product derivative library)225300.0821918NEO1
0.0491.58E-4SGTC_748act1.228 77.9 μMChemDiv (Drug-like library)44215050.0483871redox potentiating
0.0491.73E-4SGTC_13973532-0190 20.1 μMChemDiv (Drug-like library)53222800.0882353
0.0482.24E-4SGTC_21585657123 3.6 μMChembridge (Fragment library)28588270.0895522
0.0472.92E-4SGTC_496calpeptin 138.0 μMMiscellaneous733640.125
0.0463.53E-4SGTC_2570licareol 100.0 μMMicrosource (Natural product library)4431580.031746
0.0464.56E-4SGTC_8920929-0076 29.0 μMChemDiv (Drug-like library)57510380.111111TRP & mitochondrial translation
0.0454.83E-4SGTC_3014119-0100 24.5 μMChemDiv (Drug-like library)28010.0958904NEO1

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_7991310-0557151 μM0.551025354492ChemDiv (Drug-like library)252.264683.4703superoxide
SGTC_1710st03175861.5 μM0.5344835394341TimTec (Natural product derivative library)325.31542.70515
SGTC_2587piperic acid92.2 μM0.4705885370536Microsource (Natural product library)218.20542.16314
SGTC_1795st04954562.3 μM0.4285715291882TimTec (Natural product derivative library)321.15484.79803TSC3-RPN4
SGTC_1594piperine70.1 μM0.421053638024TimTec (Pure natural product library)285.337662.86403
SGTC_2683piperine63.03 μM0.421053638024TimTec (Pure natural product library)285.337662.86403
SGTC_1721st0821529.27 μM0.4098365296051TimTec (Natural product derivative library)314.337364.3551360S ribosome export
SGTC_1837st05547266.5 μM0.409836676091TimTec (Natural product derivative library)301.380123.68703
SGTC_13661683-011321.9 μM0.396226708623ChemDiv (Drug-like library)224.233121.75925
SGTC_9473447-0010211 μM0.375748350ChemDiv (Drug-like library)238.24142.59813
SGTC_610978-832798.57 μM0.3684216150059ChemDiv (Drug-like library)350.154412.5112ergosterol biosynthesis