4106-0040

1-carbazol-9-yl-3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propan-2-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1441
Screen concentration 13.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 2904180
SMILES C1CN(CCN1CC2=CC=C(C=C2)Cl)CC(CN3C4=CC=CC=C4C5=CC=CC=C53)O
Standardized SMILES OC(CN1CCN(Cc2ccc(Cl)cc2)CC1)Cn3c4ccccc4c5ccccc35
Molecular weight 433.973
ALogP 5.36
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.95
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2904180
Download HIP data (tab-delimited text)  (excel)
Gene:IRR1(YIL026C)|FD-Score:3.71|P-value:1.05E-4|Clearance:0.04||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:KRE5(YOR336W)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.05||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:NIC96(YFR002W)|FD-Score:3.62|P-value:1.49E-4|Clearance:0.01||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:NOP8(YOL144W)|FD-Score:3.49|P-value:2.45E-4|Clearance:0.3||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUP85(YJR042W)|FD-Score:4.27|P-value:9.85E-6|Clearance:0.32||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:RER2(YBR002C)|FD-Score:4.28|P-value:9.20E-6|Clearance:0.32||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPL10(YLR075W)|FD-Score:3.94|P-value:4.02E-5|Clearance:0.16||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPL18A(YOL120C)|FD-Score:3.61|P-value:1.52E-4|Clearance:0.1||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RPS2(YGL123W)|FD-Score:3.18|P-value:7.32E-4|Clearance:0.2||SGD DESC:Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 Gene:YLR458W(YLR458W_d)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Gene:YNL114C(YNL114C_d)|FD-Score:3.78|P-value:7.70E-5|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Gene:IRR1(YIL026C)|FD-Score:3.71|P-value:1.05E-4|Clearance:0.04||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:KRE5(YOR336W)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.05||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:NIC96(YFR002W)|FD-Score:3.62|P-value:1.49E-4|Clearance:0.01||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:NOP8(YOL144W)|FD-Score:3.49|P-value:2.45E-4|Clearance:0.3||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUP85(YJR042W)|FD-Score:4.27|P-value:9.85E-6|Clearance:0.32||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 Gene:RER2(YBR002C)|FD-Score:4.28|P-value:9.20E-6|Clearance:0.32||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPL10(YLR075W)|FD-Score:3.94|P-value:4.02E-5|Clearance:0.16||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:RPL18A(YOL120C)|FD-Score:3.61|P-value:1.52E-4|Clearance:0.1||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RPS2(YGL123W)|FD-Score:3.18|P-value:7.32E-4|Clearance:0.2||SGD DESC:Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 Gene:YLR458W(YLR458W_d)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Gene:YNL114C(YNL114C_d)|FD-Score:3.78|P-value:7.70E-5|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2904180
Download HOP data (tab-delimited text)  (excel)
Gene:AIM32(YML050W)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:BAR1(YIL015W)|FD-Score:3.79|P-value:7.46E-5||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:CIN1(YOR349W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:CMR3(YPR013C_p)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Putative zinc finger protein; YPR013C is not an essential gene Gene:EMC1(YCL045C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 Gene:EMC6(YLL014W)|FD-Score:4.67|P-value:1.52E-6||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:ERV46(YAL042W)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:FUN30(YAL019W)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate Gene:GMH1(YKR030W)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting Gene:HMT1(YBR034C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IMP2'(YIL154C)|FD-Score:3.24|P-value:5.97E-4||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:KIN2(YLR096W)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p Gene:MGR1(YCL044C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA Gene:MRP13(YGR084C)|FD-Score:-3.81|P-value:6.95E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:PHM8(YER037W)|FD-Score:4.37|P-value:6.32E-6||SGD DESC:Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p Gene:RIF2(YLR453C)|FD-Score:4.93|P-value:4.03E-7||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:ROD1(YOR018W)|FD-Score:4.79|P-value:8.28E-7||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPL12A(YEL054C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication Gene:RPL2A(YFR031C-A)|FD-Score:4.6|P-value:2.14E-6||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:VAC14(YLR386W)|FD-Score:3.84|P-value:6.14E-5||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YDL211C(YDL211C_p)|FD-Score:4.54|P-value:2.83E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YGK3(YOL128C)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation Gene:YGL034C(YGL034C_d)|FD-Score:3.92|P-value:4.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL026C(YHL026C_p)|FD-Score:4.61|P-value:1.97E-6||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YJL055W(YJL055W_p)|FD-Score:3.96|P-value:3.81E-5||SGD DESC:Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU Gene:YJL215C(YJL215C_d)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR012C(YLR012C_p)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR296W(YLR296W_d)|FD-Score:-3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL193W(YNL193W_p)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YPL257W(YPL257W_p)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR092W(YPR092W_d)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ZUO1(YGR285C)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p Gene:AIM32(YML050W)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:BAR1(YIL015W)|FD-Score:3.79|P-value:7.46E-5||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:CIN1(YOR349W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Gene:CMR3(YPR013C_p)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Putative zinc finger protein; YPR013C is not an essential gene Gene:EMC1(YCL045C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 Gene:EMC6(YLL014W)|FD-Score:4.67|P-value:1.52E-6||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:ERV46(YAL042W)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:FUN30(YAL019W)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate Gene:GMH1(YKR030W)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting Gene:HMT1(YBR034C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. Gene:IMP2'(YIL154C)|FD-Score:3.24|P-value:5.97E-4||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:KIN2(YLR096W)|FD-Score:-3.33|P-value:4.34E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p Gene:MGR1(YCL044C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA Gene:MRP13(YGR084C)|FD-Score:-3.81|P-value:6.95E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:PHM8(YER037W)|FD-Score:4.37|P-value:6.32E-6||SGD DESC:Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p Gene:RIF2(YLR453C)|FD-Score:4.93|P-value:4.03E-7||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:ROD1(YOR018W)|FD-Score:4.79|P-value:8.28E-7||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPL12A(YEL054C)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication Gene:RPL2A(YFR031C-A)|FD-Score:4.6|P-value:2.14E-6||SGD DESC:Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication Gene:RPL31B(YLR406C)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:VAC14(YLR386W)|FD-Score:3.84|P-value:6.14E-5||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YDL211C(YDL211C_p)|FD-Score:4.54|P-value:2.83E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YGK3(YOL128C)|FD-Score:3.15|P-value:8.27E-4||SGD DESC:Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation Gene:YGL034C(YGL034C_d)|FD-Score:3.92|P-value:4.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL026C(YHL026C_p)|FD-Score:4.61|P-value:1.97E-6||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YJL055W(YJL055W_p)|FD-Score:3.96|P-value:3.81E-5||SGD DESC:Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU Gene:YJL215C(YJL215C_d)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR012C(YLR012C_p)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR296W(YLR296W_d)|FD-Score:-3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL193W(YNL193W_p)|FD-Score:3.47|P-value:2.65E-4||SGD DESC:Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis Gene:YPL257W(YPL257W_p)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR092W(YPR092W_d)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ZUO1(YGR285C)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR002C4.289.20E-60.33RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YJR042W4.279.85E-60.33NUP85Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
YLR075W3.944.02E-50.16RPL10Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
YNL114C_d3.787.70E-50.08YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YIL026C3.711.05E-40.04IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YOR336W3.671.21E-40.05KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YFR002W3.621.49E-40.01NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YOL120C3.611.52E-40.10RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YLR458W_d3.512.25E-40.02YLR458W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YOL144W3.492.45E-40.30NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YGL123W3.187.32E-40.20RPS2Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
YPL083C2.980.001440.02SEN54Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YDR113C2.960.001530.03PDS1Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
YDR280W2.930.001680.01RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YJL194W2.930.001720.00CDC6Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR453C4.934.03E-7RIF2Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YOR018W4.798.28E-7ROD1Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
YLL014W4.671.52E-6EMC6Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
YHL026C_p4.611.97E-6YHL026C_pPutative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YFR031C-A4.602.14E-6RPL2ARibosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
YDL211C_p4.542.83E-6YDL211C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER037W4.376.32E-6PHM8Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p
YHL033C4.161.62E-5RPL8ARibosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
YJL055W_p3.963.81E-5YJL055W_pPutative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
YGL034C_d3.924.50E-5YGL034C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR092W_d3.846.06E-5YPR092W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR386W3.846.14E-5VAC14Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YIL015W3.797.46E-5BAR1Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YPL257W_p3.631.42E-4YPL257W_pPutative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YOR349W3.611.53E-4CIN1Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl

GO enrichment analysis for SGTC_1441
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0992.21E-14SGTC_2513baicalein 25.6 μMMicrosource (Natural product library)52816050.0882353calcium & mitochondrial duress
0.0881.18E-11SGTC_400oxethazaine 37.5 μMMiscellaneous46210.115942calcium & mitochondrial duress
0.0841.32E-10SGTC_5623772-2733 112.0 μMChemDiv (Drug-like library)28768740.231884ERG2
0.0823.62E-10SGTC_2523spermine 47.7 μMMicrosource (Natural product library)11030.0188679calcium & mitochondrial duress
0.0791.26E-9SGTC_14504112-4260 37.6 μMChemDiv (Drug-like library)16331750.0875calcium & mitochondrial duress
0.0782.01E-9SGTC_1666st014829 29.0 μMTimTec (Natural product derivative library)38582300.148148calcium & mitochondrial duress
0.0773.53E-9SGTC_880180-0332 8.7 μMChemDiv (Drug-like library)31017450.116883
0.0731.71E-8SGTC_1622st003707 19.4 μMTimTec (Natural product derivative library)101408990.120879calcium & mitochondrial duress
0.0731.73E-8SGTC_7014424-0219 185.0 μMChemDiv (Drug-like library)29117790.119565calcium & mitochondrial duress
0.0732.42E-8SGTC_960929-0093 37.3 μMChemDiv (Drug-like library)69915790.0933333calcium & mitochondrial duress
0.0705.94E-8SGTC_1974544-0043 41.6 μMChemDiv (Drug-like library)8965230.205882endomembrane recycling
0.0707.59E-8SGTC_330986-0033 35.8 μMChemDiv (Drug-like library)28480820.0789474calcium & mitochondrial duress
0.0708.55E-8SGTC_30919116372 49.5 μMChembridge (Drug-like library)171697930.0666667
0.0691.27E-7SGTC_23077538926 6.3 μMChembridge (Fragment library)965820.101695
0.0681.85E-7SGTC_1863455-3465 67.3 μMChemDiv (Drug-like library)7552780.109375

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_10094106-00579.87 μM0.7058822928005ChemDiv (Drug-like library)443.580525.0314
SGTC_9001112-0045141 μM0.64444456211ChemDiv (Drug-like library)322.443944.5312NEO1
SGTC_8870885-00079.62 μM0.5660385719458ChemDiv (Drug-like library)425.565245.16513endomembrane recycling
SGTC_1721112-00462.64 μM0.562802135ChemDiv (Drug-like library)391.334065.85912NEO1
SGTC_8880916-00026.97 μM0.562802138ChemDiv (Drug-like library)377.307485.40312NEO1
SGTC_10084106-00376 μM0.5263162905394ChemDiv (Drug-like library)443.580525.23214PDR1
SGTC_5154092-1064102 μM0.4375717353ChemDiv (Drug-like library)335.27084.77302plasma membrane duress
SGTC_2784092-082123.9 μM0.434783877900ChemDiv (Drug-like library)328.87895.05102plasma membrane duress
SGTC_11991638-00104.46 μM0.4074073111136ChemDiv (Drug-like library)344.449464.52622endomembrane recycling
SGTC_12820886-001032.4 μM0.42836211ChemDiv (Drug-like library)445.42456.40112endomembrane recycling