4112-3303

4-N,4-N-dimethyl-1-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzene-1,4-diamine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1443
Screen concentration 14.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 704433
SMILES CN(C)C1=CC=C(C=C1)NC2=NC(=CS2)C3=CC=CC=N3
Standardized SMILES CN(C)c1ccc(Nc2nc(cs2)c3ccccn3)cc1
Molecular weight 296.39
ALogP 3.76
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 1.49
% growth inhibition (Hom. pool) -1.51


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 704433
Download HIP data (tab-delimited text)  (excel)
Gene:NIC96(YFR002W)|FD-Score:3.13|P-value:8.73E-4|Clearance:0.12||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:SAM50(YNL026W)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.37||SGD DESC:Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 Gene:NIC96(YFR002W)|FD-Score:3.13|P-value:8.73E-4|Clearance:0.12||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:SAM50(YNL026W)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.37||SGD DESC:Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 704433
Download HOP data (tab-delimited text)  (excel)
Gene:ADE17(YMR120C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine Gene:CIN5(YOR028C)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication Gene:COX9(YDL067C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:DSF2(YBR007C_p)|FD-Score:5.27|P-value:6.79E-8||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:DTR1(YBR180W)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation Gene:FMC1(YIL098C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p Gene:FUS2(YMR232W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Gene:GIC1(YHR061C)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:GND2(YGR256W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication Gene:GRE2(YOL151W)|FD-Score:-3.4|P-value:3.40E-4||SGD DESC:3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:HEL1(YKR017C_p)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) Gene:HSP31(YDR533C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:KTI11(YBL071W-A)|FD-Score:3.1|P-value:9.68E-4||SGD DESC:Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs Gene:LIA1(YJR070C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress Gene:LOH1(YJL038C)|FD-Score:5.39|P-value:3.51E-8||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:MET22(YOL064C)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRPS5(YBR251W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRS3(YJL133W)|FD-Score:-4.09|P-value:2.18E-5||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:PDE2(YOR360C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PEX7(YDR142C)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) Gene:PMP1(YCR024C-A)|FD-Score:4.43|P-value:4.76E-6||SGD DESC:Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication Gene:PNP1(YLR209C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway Gene:PRM4(YPL156C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift Gene:RBG1(YAL036C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RPS8A(YBL072C)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SED4(YCR067C)|FD-Score:4.03|P-value:2.77E-5||SGD DESC:Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p Gene:SKM1(YOL113W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:TMA46(YOR091W)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:YBL012C(YBL012C_d)|FD-Score:3.52|P-value:2.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL075W(YCL075W)|FD-Score:-3.19|P-value:7.09E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YCR015C(YCR015C_p)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function; YCR015C is not an essential gene Gene:YER184C(YER184C_p)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YGL088W(YGL088W_d)|FD-Score:-3.29|P-value:5.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Gene:YGR250C(YGR250C)|FD-Score:3.81|P-value:6.90E-5||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YKR104W(YKR104W)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR040C(YLR040C_p)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential Gene:YNL089C(YNL089C_d)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Gene:YNR061C(YNR061C_p)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YPR092W(YPR092W_d)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR097W(YPR097W)|FD-Score:4.57|P-value:2.48E-6||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR114W(YPR114W_p)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Putative protein of unknown function Gene:ADE17(YMR120C)|FD-Score:-3.24|P-value:6.08E-4||SGD DESC:Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine Gene:CIN5(YOR028C)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication Gene:COX9(YDL067C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:DSF2(YBR007C_p)|FD-Score:5.27|P-value:6.79E-8||SGD DESC:Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:DTR1(YBR180W)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation Gene:FMC1(YIL098C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p Gene:FUS2(YMR232W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Gene:GIC1(YHR061C)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress Gene:GND2(YGR256W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication Gene:GRE2(YOL151W)|FD-Score:-3.4|P-value:3.40E-4||SGD DESC:3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:HEL1(YKR017C_p)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) Gene:HSP31(YDR533C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:KTI11(YBL071W-A)|FD-Score:3.1|P-value:9.68E-4||SGD DESC:Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs Gene:LIA1(YJR070C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress Gene:LOH1(YJL038C)|FD-Score:5.39|P-value:3.51E-8||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:MET22(YOL064C)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRPS5(YBR251W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRS3(YJL133W)|FD-Score:-4.09|P-value:2.18E-5||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:PDE2(YOR360C)|FD-Score:4.08|P-value:2.22E-5||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PEX7(YDR142C)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) Gene:PMP1(YCR024C-A)|FD-Score:4.43|P-value:4.76E-6||SGD DESC:Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication Gene:PNP1(YLR209C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway Gene:PRM4(YPL156C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift Gene:RBG1(YAL036C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RPS8A(YBL072C)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SED4(YCR067C)|FD-Score:4.03|P-value:2.77E-5||SGD DESC:Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p Gene:SKM1(YOL113W)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:TMA46(YOR091W)|FD-Score:3.39|P-value:3.54E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:YBL012C(YBL012C_d)|FD-Score:3.52|P-value:2.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL075W(YCL075W)|FD-Score:-3.19|P-value:7.09E-4||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YCR015C(YCR015C_p)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function; YCR015C is not an essential gene Gene:YER184C(YER184C_p)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gene:YGL088W(YGL088W_d)|FD-Score:-3.29|P-value:5.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Gene:YGR250C(YGR250C)|FD-Score:3.81|P-value:6.90E-5||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YKR104W(YKR104W)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR040C(YLR040C_p)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential Gene:YNL089C(YNL089C_d)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Gene:YNR061C(YNR061C_p)|FD-Score:3.12|P-value:9.18E-4||SGD DESC:Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YPR092W(YPR092W_d)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR097W(YPR097W)|FD-Score:4.57|P-value:2.48E-6||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR114W(YPR114W_p)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL026W3.502.34E-40.37SAM50Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
YFR002W3.138.73E-40.12NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YMR227C3.010.001310.04TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YGR119C2.970.001480.03NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YFL039C2.940.001640.06ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YBR070C2.880.001970.02ALG14Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
YMR268C2.860.002110.01PRP24Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YLR166C2.850.002210.02SEC10Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion
YGL116W2.830.002330.15CDC20Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
YOR340C2.680.003720.04RPA43RNA polymerase I subunit A43
YPR110C2.640.004150.01RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YGR115C_d2.630.004300.02YGR115C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
YKL172W2.610.004520.01EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YDR189W2.610.004590.04SLY1Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YGL047W2.570.005100.04ALG13Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJL038C5.393.51E-8LOH1Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
YBR007C_p5.276.79E-8DSF2_pDeletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
YPR097W4.572.48E-6YPR097WProtein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR024C-A4.434.76E-6PMP1Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication
YOR360C4.082.22E-5PDE2High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
YBR180W4.072.39E-5DTR1Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
YCR067C4.032.77E-5SED4Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p
YGR250C3.816.90E-5YGR250CPutative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YBL072C3.749.17E-5RPS8AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
YJR070C3.581.69E-4LIA1Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress
YPR114W_p3.542.00E-4YPR114W_pPutative protein of unknown function
YBL012C_d3.522.15E-4YBL012C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL113W3.512.25E-4SKM1Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
YPR092W_d3.502.36E-4YPR092W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR232W3.433.00E-4FUS2Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating

GO enrichment analysis for SGTC_1443
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0656.38E-7SGTC_14304049-0248 69.1 μMChemDiv (Drug-like library)227744880.142857
0.0596.35E-6SGTC_11283448-9350 235.0 μMChemDiv (Drug-like library)6193860.128205
0.0596.66E-6SGTC_21896047310 154.4 μMChembridge (Fragment library)7115350.0882353RPP1 & pyrimidine depletion
0.0571.15E-5SGTC_1472k841-0093 193.0 μMChemDiv (Drug-like library)X14720.0657895
0.0561.41E-5SGTC_1685st024049 53.1 μMTimTec (Natural product derivative library)19411390.0722892TSC3-RPN4
0.0561.69E-5SGTC_15024534-4282 27.7 μMChemDiv (Drug-like library)32789490.142857
0.0561.83E-5SGTC_1471k673-0312 37.0 μMChemDiv (Drug-like library)240998840.0379747RNA processing & uracil transport
0.0552.09E-5SGTC_23689071271 200.0 μMChembridge (Fragment library)272099590.1
0.0543.17E-5SGTC_29117942208 15.6 μMChembridge (Drug-like library)12433840.101449mitochondrial response to ROS
0.0526.59E-5SGTC_26323-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100.0 μMMicrosource (Natural product library)68577840.025974
0.0501.19E-4SGTC_15516-bromo-3'-methylflavone 63.5 μMTimTec (Pure natural product library)6887510.0714286
0.0491.47E-4SGTC_2674ligustilide 100.0 μMMicrosource (Natural product library)53190220.0434783
0.0491.51E-4SGTC_14374092-1038 11.6 μMChemDiv (Drug-like library)39771360.0151515
0.0472.90E-4SGTC_503tyrphostin 8 294.0 μMICCB bioactive library929700.0526316TSC3-RPN4
0.0473.01E-4SGTC_10214476-0760 85.3 μMChemDiv (Drug-like library)7467680.0821918

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_14764112-32943.34 μM0.697674704369ChemDiv (Drug-like library)332.21834.351460S ribosome export
SGTC_14424112-32903 μM0.617021704353ChemDiv (Drug-like library)267.348824.08814
SGTC_10104112-329615.2 μM0.55102704384ChemDiv (Drug-like library)283.348223.58515
SGTC_1524469-0003551.23 μM0.458333697280ChemDiv (Drug-like library)268.333584.08224
SGTC_6281636-025316 μM0.4583334456143ChemDiv (Drug-like library)331.230245.07213sphingolipid biosynthesis & PDR1
SGTC_10124112-352218 μM0.3753112398ChemDiv (Drug-like library)322.836243.81326
SGTC_14954469-0029237 μM0.375793680ChemDiv (Drug-like library)337.440342.98227
SGTC_8024112-3352742 μM0.368421704594ChemDiv (Drug-like library)267.348823.65914
SGTC_14444112-358128 μM0.3389832877249ChemDiv (Drug-like library)303.402523.37226
SGTC_14514152-0210104 μM0.333333659563ChemDiv (Drug-like library)234.2562.66104