Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR033W | 8.32 | 4.49E-17 | 2.17 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YER021W | 6.15 | 3.85E-10 | 0.92 | RPN3 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control |
YHR036W | 5.23 | 8.49E-8 | 0.71 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YKR086W | 4.51 | 3.17E-6 | 0.02 | PRP16 | DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step |
YOR340C | 4.49 | 3.50E-6 | 0.01 | RPA43 | RNA polymerase I subunit A43 |
YOR336W | 4.48 | 3.72E-6 | 0.23 | KRE5 | Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects |
YDR113C | 4.25 | 1.06E-5 | 0.16 | PDS1 | Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation |
YER038C | 4.10 | 2.11E-5 | 0.42 | KRE29 | Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance |
YLL035W | 3.67 | 1.20E-4 | 0.24 | GRC3 | Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated |
YKL045W | 3.43 | 2.97E-4 | 0.07 | PRI2 | Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair |
YML127W | 3.36 | 3.87E-4 | 0.08 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YOR224C | 3.28 | 5.20E-4 | 0.07 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YDR016C | 3.21 | 6.69E-4 | 0.02 | DAD1 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
YIL126W | 3.19 | 7.15E-4 | 0.09 | STH1 | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
YIR011C | 3.10 | 9.76E-4 | 0.05 | STS1 | Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation |