Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGL071W | 8.79 | 7.75E-19 | AFT1 | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
YBL006C | 5.61 | 9.87E-9 | LDB7 | Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions |
YBR157C | 5.58 | 1.22E-8 | ICS2 | Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization |
YJL045W | 5.53 | 1.60E-8 | YJL045W | Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
YNL125C | 5.42 | 2.97E-8 | ESBP6 | Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane |
YEL060C | 5.16 | 1.25E-7 | PRB1 | Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress |
YDR509W_d | 4.99 | 2.99E-7 | YDR509W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YBR058C-A | 4.96 | 3.57E-7 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YAR047C_d | 4.80 | 7.75E-7 | YAR047C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YER169W | 4.77 | 9.12E-7 | RPH1 | JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication |
YPR191W | 4.73 | 1.12E-6 | QCR2 | Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme |
YBR288C | 4.69 | 1.40E-6 | APM3 | Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway |
YOR036W | 4.57 | 2.40E-6 | PEP12 | Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin |
YLR213C | 4.40 | 5.49E-6 | CRR1 | Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation |
YDL238C | 4.37 | 6.21E-6 | GUD1 | Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures |