Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBL093C | 7.34 | 1.05E-13 | ROX3 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme |
YPL118W | 6.39 | 8.34E-11 | MRP51 | Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences |
YAR002W | 6.18 | 3.19E-10 | NUP60 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 |
YGR241C | 6.06 | 6.82E-10 | YAP1802 | Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication |
YNR071C_p | 5.93 | 1.50E-9 | YNR071C_p | Putative aldose 1-epimerase |
YBR107C | 5.33 | 4.93E-8 | IML3 | Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 |
YDR445C_d | 5.33 | 4.95E-8 | YDR445C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YNL079C | 5.29 | 6.20E-8 | TPM1 | Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication |
YKL009W | 5.01 | 2.69E-7 | MRT4 | Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus |
YPR028W | 4.98 | 3.16E-7 | YOP1 | Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress |
YGR232W | 4.93 | 4.03E-7 | NAS6 | Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 |
YER174C | 4.86 | 5.88E-7 | GRX4 | Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5 |
YGR268C | 4.82 | 7.21E-7 | HUA1 | Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly |
YNL065W | 4.81 | 7.72E-7 | AQR1 | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YNL107W | 4.71 | 1.23E-6 | YAF9 | Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain |