| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YJL201W | 6.14 | 4.24E-10 | ECM25 | Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p |
| YJL192C | 5.15 | 1.28E-7 | SOP4 | ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER |
| YDR234W | 4.79 | 8.16E-7 | LYS4 | Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway |
| YKL006W | 4.72 | 1.16E-6 | RPL14A | Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication |
| YNR013C | 4.52 | 3.16E-6 | PHO91 | Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth |
| YDR076W | 4.21 | 1.29E-5 | RAD55 | Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p |
| YBR007C_p | 4.12 | 1.92E-5 | DSF2_p | Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YNL160W | 3.88 | 5.33E-5 | YGP1 | Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p |
| YDR315C | 3.87 | 5.45E-5 | IPK1 | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable |
| YLR421C | 3.72 | 9.78E-5 | RPN13 | Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress |
| YPR022C_p | 3.69 | 1.14E-4 | YPR022C_p | Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS |
| YOL014W_p | 3.66 | 1.24E-4 | YOL014W_p | Putative protein of unknown function |
| YOL013W-A_p | 3.63 | 1.42E-4 | YOL013W-A_p | Putative protein of unknown function; identified by SAGE |
| YPR030W | 3.60 | 1.57E-4 | CSR2 | Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication |
| YER169W | 3.59 | 1.65E-4 | RPH1 | JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication |
