Deletion Strain | FD score | P-value | Gene | Gene Description |
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YAL044C | 6.11 | 4.89E-10 | GCV3 | H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF |
YBL104C | 5.34 | 4.60E-8 | SEA4 | Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites |
YJR105W | 5.01 | 2.78E-7 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
YBR064W_d | 4.82 | 7.07E-7 | YBR064W_d | Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C |
YOR351C | 4.72 | 1.20E-6 | MEK1 | Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids |
YPL049C | 4.65 | 1.63E-6 | DIG1 | MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p |
YGL095C | 4.63 | 1.85E-6 | VPS45 | Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment |
YPR123C_d | 4.55 | 2.73E-6 | YPR123C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
YER122C | 4.42 | 4.88E-6 | GLO3 | ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p |
YKR085C | 4.40 | 5.39E-6 | MRPL20 | Mitochondrial ribosomal protein of the large subunit |
YLR418C | 4.40 | 5.53E-6 | CDC73 | Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress |
YMR233W | 4.39 | 5.66E-6 | TRI1 | Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication |
YPR084W_p | 4.33 | 7.37E-6 | YPR084W_p | Putative protein of unknown function |
YHR047C | 4.12 | 1.87E-5 | AAP1 | Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication |
YPL183W-A | 4.04 | 2.63E-5 | RTC6 | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |