1070-0044

4-(3-carbazol-9-ylpropyl)morpholine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1480
Screen concentration 41.2 μM
Source ChemDiv (Drug-like library)
PubChem CID 3124987
SMILES C1COCCN1CCCN2C3=CC=CC=C3C4=CC=CC=C42
Standardized SMILES C(CN1CCOCC1)Cn2c3ccccc3c4ccccc24
Molecular weight 294.3908
ALogP 3.42
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.88
% growth inhibition (Hom. pool) 5


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3124987
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:3.13|P-value:8.63E-4|Clearance:0.03||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT7(YJL111W)|FD-Score:3.18|P-value:7.24E-4|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC12(YHR107C)|FD-Score:9.03|P-value:8.82E-20|Clearance:2.74||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:NOP56(YLR197W)|FD-Score:6.29|P-value:1.58E-10|Clearance:2.11||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RRP43(YCR035C)|FD-Score:4.12|P-value:1.92E-5|Clearance:0.59||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress Gene:RSC6(YCR052W)|FD-Score:3.26|P-value:5.50E-4|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC23(YPR181C)|FD-Score:4.18|P-value:1.45E-5|Clearance:0.06||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SSL1(YLR005W)|FD-Score:3.17|P-value:7.75E-4|Clearance:0.03||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:YKL111C(YKL111C_d)|FD-Score:3.1|P-value:9.60E-4|Clearance:0.02||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1 Gene:YNL150W(YNL150W_d)|FD-Score:3.53|P-value:2.07E-4|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking Gene:ARP7(YPR034W)|FD-Score:3.13|P-value:8.63E-4|Clearance:0.03||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT7(YJL111W)|FD-Score:3.18|P-value:7.24E-4|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC12(YHR107C)|FD-Score:9.03|P-value:8.82E-20|Clearance:2.74||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:NOP56(YLR197W)|FD-Score:6.29|P-value:1.58E-10|Clearance:2.11||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RRP43(YCR035C)|FD-Score:4.12|P-value:1.92E-5|Clearance:0.59||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress Gene:RSC6(YCR052W)|FD-Score:3.26|P-value:5.50E-4|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC23(YPR181C)|FD-Score:4.18|P-value:1.45E-5|Clearance:0.06||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SSL1(YLR005W)|FD-Score:3.17|P-value:7.75E-4|Clearance:0.03||SGD DESC:Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p Gene:YKL111C(YKL111C_d)|FD-Score:3.1|P-value:9.60E-4|Clearance:0.02||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1 Gene:YNL150W(YNL150W_d)|FD-Score:3.53|P-value:2.07E-4|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3124987
Download HOP data (tab-delimited text)  (excel)
Gene:AAP1(YHR047C)|FD-Score:4.12|P-value:1.87E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ADO1(YJR105W)|FD-Score:5.01|P-value:2.78E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APL5(YPL195W)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:BCK1(YJL095W)|FD-Score:3.84|P-value:6.17E-5||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:BUD30(YDL151C_d)|FD-Score:3.11|P-value:9.35E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CBS1(YDL069C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CDC73(YLR418C)|FD-Score:4.4|P-value:5.53E-6||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CNM67(YNL225C)|FD-Score:3.1|P-value:9.53E-4||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:COX20(YDR231C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase Gene:CPA1(YOR303W)|FD-Score:-3.44|P-value:2.89E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CPR6(YLR216C)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress Gene:DCC1(YCL016C)|FD-Score:3.9|P-value:4.73E-5||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:DIG1(YPL049C)|FD-Score:4.65|P-value:1.63E-6||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DST1(YGL043W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress Gene:ERG2(YMR202W)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:GCV3(YAL044C)|FD-Score:6.11|P-value:4.89E-10||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:GLO3(YER122C)|FD-Score:4.42|P-value:4.88E-6||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p Gene:IFM1(YOL023W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IMP2(YMR035W)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p Gene:MDE1(YJR024C)|FD-Score:3.93|P-value:4.33E-5||SGD DESC:5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant Gene:MEK1(YOR351C)|FD-Score:4.72|P-value:1.20E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MET6(YER091C)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs Gene:MNN11(YJL183W)|FD-Score:-3.15|P-value:8.27E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MRP8(YKL142W)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MRPL20(YKR085C)|FD-Score:4.4|P-value:5.39E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL27(YBR282W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP Gene:MRPL39(YML009C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTM1(YGR257C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:PRO1(YDR300C)|FD-Score:-3.76|P-value:8.36E-5||SGD DESC:Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication Gene:RAV2(YDR202C)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme Gene:RIP1(YEL024W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly Gene:RPS16A(YMR143W)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication Gene:RTC6(YPL183W-A)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:RTS3(YGR161C_p)|FD-Score:3.28|P-value:5.11E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SAS4(YDR181C)|FD-Score:4.03|P-value:2.76E-5||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p Gene:SCO1(YBR037C)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SEA4(YBL104C)|FD-Score:5.34|P-value:4.60E-8||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEC28(YIL076W)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress Gene:SIP5(YMR140W)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SOD1(YJR104C)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TRI1(YMR233W)|FD-Score:4.39|P-value:5.66E-6||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:TRP3(YKL211C)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPS45(YGL095C)|FD-Score:4.63|P-value:1.85E-6||SGD DESC:Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment Gene:VPS71(YML041C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBR064W(YBR064W_d)|FD-Score:4.82|P-value:7.07E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Gene:YDL068W(YDL068W_d)|FD-Score:4.02|P-value:2.95E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR230W-A(YMR230W-A_p)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Putative protein of unknown function Gene:YMR244W(YMR244W_p)|FD-Score:3.09|P-value:9.92E-4||SGD DESC:Putative protein of unknown function Gene:YNL296W(YNL296W_d)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YOR097C(YOR097C_p)|FD-Score:3.74|P-value:9.35E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YOR105W(YOR105W_p)|FD-Score:3.09|P-value:9.93E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YPL216W(YPL216W_p)|FD-Score:3.98|P-value:3.39E-5||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene Gene:YPR084W(YPR084W_p)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Putative protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:AAP1(YHR047C)|FD-Score:4.12|P-value:1.87E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ADO1(YJR105W)|FD-Score:5.01|P-value:2.78E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APL5(YPL195W)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:BCK1(YJL095W)|FD-Score:3.84|P-value:6.17E-5||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:BUD30(YDL151C_d)|FD-Score:3.11|P-value:9.35E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CBS1(YDL069C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CDC73(YLR418C)|FD-Score:4.4|P-value:5.53E-6||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CNM67(YNL225C)|FD-Score:3.1|P-value:9.53E-4||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:COX20(YDR231C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase Gene:CPA1(YOR303W)|FD-Score:-3.44|P-value:2.89E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CPR6(YLR216C)|FD-Score:3.19|P-value:7.20E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress Gene:DCC1(YCL016C)|FD-Score:3.9|P-value:4.73E-5||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:DIG1(YPL049C)|FD-Score:4.65|P-value:1.63E-6||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DST1(YGL043W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress Gene:ERG2(YMR202W)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:GCV3(YAL044C)|FD-Score:6.11|P-value:4.89E-10||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:GLO3(YER122C)|FD-Score:4.42|P-value:4.88E-6||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p Gene:IFM1(YOL023W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IMP2(YMR035W)|FD-Score:3.23|P-value:6.16E-4||SGD DESC:Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p Gene:MDE1(YJR024C)|FD-Score:3.93|P-value:4.33E-5||SGD DESC:5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant Gene:MEK1(YOR351C)|FD-Score:4.72|P-value:1.20E-6||SGD DESC:Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids Gene:MET6(YER091C)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs Gene:MNN11(YJL183W)|FD-Score:-3.15|P-value:8.27E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:MRP8(YKL142W)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MRPL20(YKR085C)|FD-Score:4.4|P-value:5.39E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL27(YBR282W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP Gene:MRPL39(YML009C)|FD-Score:3.13|P-value:8.82E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MTM1(YGR257C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:PRO1(YDR300C)|FD-Score:-3.76|P-value:8.36E-5||SGD DESC:Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication Gene:RAV2(YDR202C)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme Gene:RIP1(YEL024W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly Gene:RPS16A(YMR143W)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication Gene:RTC6(YPL183W-A)|FD-Score:4.04|P-value:2.63E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:RTS3(YGR161C_p)|FD-Score:3.28|P-value:5.11E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SAS4(YDR181C)|FD-Score:4.03|P-value:2.76E-5||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p Gene:SCO1(YBR037C)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SEA4(YBL104C)|FD-Score:5.34|P-value:4.60E-8||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SEC28(YIL076W)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress Gene:SIP5(YMR140W)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SOD1(YJR104C)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TRI1(YMR233W)|FD-Score:4.39|P-value:5.66E-6||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:TRP3(YKL211C)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPS45(YGL095C)|FD-Score:4.63|P-value:1.85E-6||SGD DESC:Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment Gene:VPS71(YML041C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBR064W(YBR064W_d)|FD-Score:4.82|P-value:7.07E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Gene:YDL068W(YDL068W_d)|FD-Score:4.02|P-value:2.95E-5||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR230W-A(YMR230W-A_p)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Putative protein of unknown function Gene:YMR244W(YMR244W_p)|FD-Score:3.09|P-value:9.92E-4||SGD DESC:Putative protein of unknown function Gene:YNL296W(YNL296W_d)|FD-Score:3.83|P-value:6.39E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Gene:YOL038C-A(YOL038C-A_p)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Putative protein of unknown function; identified by SAGE analysis Gene:YOR097C(YOR097C_p)|FD-Score:3.74|P-value:9.35E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YOR105W(YOR105W_p)|FD-Score:3.09|P-value:9.93E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YPL216W(YPL216W_p)|FD-Score:3.98|P-value:3.39E-5||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene Gene:YPR084W(YPR084W_p)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Putative protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:4.55|P-value:2.73E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR107C9.038.82E-202.74CDC12Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YLR197W6.291.58E-102.11NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YPR181C4.181.45E-50.06SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YCR035C4.121.92E-50.58RRP43Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress
YNL150W_d3.532.07E-40.27YNL150W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
YCR052W3.265.50E-40.08RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YJL111W3.187.24E-40.02CCT7Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
YLR005W3.177.75E-40.03SSL1Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YPR034W3.138.63E-40.03ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YKL111C_d3.109.60E-40.02YKL111C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
YBR202W3.090.001010.06MCM7Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
YDL097C3.030.001240.02RPN6Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
YOL144W3.000.001340.02NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YBR143C2.980.001430.18SUP45Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
YGR115C_d2.810.002510.03YGR115C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YAL044C6.114.89E-10GCV3H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
YBL104C5.344.60E-8SEA4Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
YJR105W5.012.78E-7ADO1Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YBR064W_d4.827.07E-7YBR064W_dDubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
YOR351C4.721.20E-6MEK1Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
YPL049C4.651.63E-6DIG1MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
YGL095C4.631.85E-6VPS45Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
YPR123C_d4.552.73E-6YPR123C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
YER122C4.424.88E-6GLO3ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
YKR085C4.405.39E-6MRPL20Mitochondrial ribosomal protein of the large subunit
YLR418C4.405.53E-6CDC73Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
YMR233W4.395.66E-6TRI1Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication
YPR084W_p4.337.37E-6YPR084W_pPutative protein of unknown function
YHR047C4.121.87E-5AAP1Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
YPL183W-A4.042.63E-5RTC6Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_1480
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1094.00E-17SGTC_1060092-0003 11.6 μMChemDiv (Drug-like library)10721480.0862069copper-dependent oxidative stress
0.1031.58E-15SGTC_31229126309 49.5 μMChembridge (Drug-like library)175912060.134328cell wall signaling
0.0939.14E-13SGTC_2575plumbagin 510.0 nMTimTec (Pure natural product library)102050.0727273superoxide
0.0921.65E-12SGTC_1865st057639 52.2 μMTimTec (Natural product derivative library)6888180.078125
0.0831.62E-10SGTC_20805212524 12.4 μMChembridge (Fragment library)2601830.0980392copper-dependent oxidative stress
0.0831.73E-10SGTC_8251988-2224 89.6 μMChemDiv (Drug-like library)11808590.0533333cell wall signaling
0.0814.97E-10SGTC_1064honokiol 6.8 μMNIH Clinical Collection723030.0677966
0.0815.20E-10SGTC_22727805186 180.0 μMChembridge (Fragment library)29560620.0625cell wall signaling
0.0806.29E-10SGTC_2507purpurin 79.7 μMMicrosource (Natural product library)66830.0980392copper-dependent oxidative stress
0.0806.71E-10SGTC_1963st076565 50.3 μMTimTec (Natural product derivative library)49142800.16
0.0791.07E-9SGTC_30889117578 49.5 μMChembridge (Drug-like library)6783410.0677966amide catabolism
0.0759.04E-9SGTC_6120302-0167 22.4 μMChemDiv (Drug-like library)2358210.0892857copper-dependent oxidative stress
0.0741.07E-8SGTC_23529027995 87.8 μMChembridge (Fragment library)29973470.0819672tubulin folding & SWR complex
0.0741.06E-8SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.0571429Golgi
0.0741.15E-8SGTC_22997976368 114.9 μMChembridge (Fragment library)29797180.0862069

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1096rimcazole32.2 μM0.5581418528119NIH Clinical Collection375.93544.08133
SGTC_3019908197149.47 μM0.416451803Chembridge (Drug-like library)357.448223.99703
SGTC_9001112-0045141 μM0.38297956211ChemDiv (Drug-like library)322.443944.5312NEO1
SGTC_20935331342194.4 μM0.38297933839Chembridge (Fragment library)243.300982.25713
SGTC_21495554786194.83 μM0.346939745063Chembridge (Fragment library)230.308821.94613cell wall signaling
SGTC_10084106-00376 μM0.3448282905394ChemDiv (Drug-like library)443.580525.23214PDR1
SGTC_12021988-006829.6 μM0.3442622850480ChemDiv (Drug-like library)426.555.45913RNA processing & uracil transport
SGTC_2801790780081.82 μM0.3333336620925Chembridge (Drug-like library)343.421643.40203
SGTC_14414106-004013 μM0.3272732904180ChemDiv (Drug-like library)433.973025.36213
SGTC_2898905627058.44 μM0.32258119154699Chembridge (Drug-like library)352.38381.80215