Deletion Strain | FD score | P-value | Gene | Gene Description |
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YML048W | 8.49 | 1.07E-17 | GSF2 | ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression |
YNL041C | 5.34 | 4.63E-8 | COG6 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YGL045W | 4.46 | 4.02E-6 | RIM8 | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family |
YHL015W-A_p | 4.45 | 4.23E-6 | YHL015W-A_p | Putative protein of unknown function |
YBR003W | 4.30 | 8.43E-6 | COQ1 | Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis |
YJL172W | 4.28 | 9.52E-6 | CPS1 | Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions |
YML099C | 4.25 | 1.07E-5 | ARG81 | Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p |
YHR096C | 4.25 | 1.09E-5 | HXT5 | Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication |
YLR372W | 4.17 | 1.52E-5 | SUR4 | Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
YPR027C_p | 4.02 | 2.90E-5 | YPR027C_p | Putative protein of unknown function |
YMR090W_p | 3.95 | 3.94E-5 | YMR090W_p | Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability |
YKL212W | 3.88 | 5.20E-5 | SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism |
YDL178W | 3.87 | 5.46E-5 | DLD2 | D-lactate dehydrogenase, located in the mitochondrial matrix |
YLR330W | 3.76 | 8.52E-5 | CHS5 | Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane |
YLR268W | 3.69 | 1.12E-4 | SEC22 | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog |