3346-2004

1-[4-(2-fluorophenyl)piperazin-1-yl]-3-[(2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl)oxy]propan-2-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1481
Screen concentration 36.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 2770522
SMILES CC1(C2CCC(C2)(C1OCC(CN3CCN(CC3)C4=CC=CC=C4F)O)C)C
Standardized SMILES CC12CCC(C1)C(C)(C)C2OCC(O)CN3CCN(CC3)c4ccccc4F
Molecular weight 390.5346
ALogP 3.98
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 21.22
% growth inhibition (Hom. pool) 5.98


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2770522
Download HIP data (tab-delimited text)  (excel)
Gene:CDC20(YGL116W)|FD-Score:-3.15|P-value:8.28E-4|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:ERG11(YHR007C)|FD-Score:3.09|P-value:9.90E-4|Clearance:0.21||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:HYP2(YEL034W)|FD-Score:6.1|P-value:5.23E-10|Clearance:1.2||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:RSC6(YCR052W)|FD-Score:4.9|P-value:4.82E-7|Clearance:0.59||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:RSC8(YFR037C)|FD-Score:3.42|P-value:3.14E-4|Clearance:0.07||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SPC105(YGL093W)|FD-Score:4.31|P-value:8.33E-6|Clearance:0.31||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:TOM40(YMR203W)|FD-Score:3.99|P-value:3.28E-5|Clearance:0.57||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDR187C(YDR187C_d)|FD-Score:3.35|P-value:4.09E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YJL086C(YJL086C_d)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:CDC20(YGL116W)|FD-Score:-3.15|P-value:8.28E-4|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:ERG11(YHR007C)|FD-Score:3.09|P-value:9.90E-4|Clearance:0.21||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:HYP2(YEL034W)|FD-Score:6.1|P-value:5.23E-10|Clearance:1.2||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:RSC6(YCR052W)|FD-Score:4.9|P-value:4.82E-7|Clearance:0.59||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:RSC8(YFR037C)|FD-Score:3.42|P-value:3.14E-4|Clearance:0.07||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SPC105(YGL093W)|FD-Score:4.31|P-value:8.33E-6|Clearance:0.31||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:TOM40(YMR203W)|FD-Score:3.99|P-value:3.28E-5|Clearance:0.57||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDR187C(YDR187C_d)|FD-Score:3.35|P-value:4.09E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YJL086C(YJL086C_d)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2770522
Download HOP data (tab-delimited text)  (excel)
Gene:AAP1(YHR047C)|FD-Score:-4.2|P-value:1.36E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ADA2(YDR448W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:ARG81(YML099C)|FD-Score:4.25|P-value:1.07E-5||SGD DESC:Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p Gene:ARO4(YBR249C)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress Gene:CHS5(YLR330W)|FD-Score:3.76|P-value:8.52E-5||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:COG6(YNL041C)|FD-Score:5.34|P-value:4.63E-8||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ1(YBR003W)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis Gene:CPS1(YJL172W)|FD-Score:4.28|P-value:9.52E-6||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:DEP1(YAL013W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation Gene:DLD2(YDL178W)|FD-Score:3.87|P-value:5.46E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:ECM33(YBR078W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ECM8(YBR076W)|FD-Score:3.2|P-value:6.76E-4||SGD DESC:Non-essential protein of unknown function Gene:FIR1(YER032W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate Gene:GSF2(YML048W)|FD-Score:8.49|P-value:1.07E-17||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HXT5(YHR096C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication Gene:IPK1(YDR315C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:LEM3(YNL323W)|FD-Score:3.14|P-value:8.38E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:PET191(YJR034W)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery Gene:PKH3(YDR466W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PUN1(YLR414C)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress Gene:RAV1(YJR033C)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RIM8(YGL045W)|FD-Score:4.46|P-value:4.02E-6||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL11B(YGR085C)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:3.88|P-value:5.20E-5||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SDT1(YGL224C)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives Gene:SEC22(YLR268W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SPS19(YNL202W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate Gene:SUR4(YLR372W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:THO2(YNL139C)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids Gene:TUF1(YOR187W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YHL015W-A(YHL015W-A_p)|FD-Score:4.45|P-value:4.23E-6||SGD DESC:Putative protein of unknown function Gene:YJL147C(YJL147C_p)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene Gene:YMR090W(YMR090W_p)|FD-Score:3.95|P-value:3.94E-5||SGD DESC:Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability Gene:YPR027C(YPR027C_p)|FD-Score:4.02|P-value:2.90E-5||SGD DESC:Putative protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:AAP1(YHR047C)|FD-Score:-4.2|P-value:1.36E-5||SGD DESC:Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication Gene:ADA2(YDR448W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:ARG81(YML099C)|FD-Score:4.25|P-value:1.07E-5||SGD DESC:Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p Gene:ARO4(YBR249C)|FD-Score:-3.55|P-value:1.90E-4||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress Gene:CHS5(YLR330W)|FD-Score:3.76|P-value:8.52E-5||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:COG6(YNL041C)|FD-Score:5.34|P-value:4.63E-8||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ1(YBR003W)|FD-Score:4.3|P-value:8.43E-6||SGD DESC:Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis Gene:CPS1(YJL172W)|FD-Score:4.28|P-value:9.52E-6||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:DEP1(YAL013W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation Gene:DLD2(YDL178W)|FD-Score:3.87|P-value:5.46E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:ECM33(YBR078W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ECM8(YBR076W)|FD-Score:3.2|P-value:6.76E-4||SGD DESC:Non-essential protein of unknown function Gene:FIR1(YER032W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate Gene:GSF2(YML048W)|FD-Score:8.49|P-value:1.07E-17||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HXT5(YHR096C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication Gene:IPK1(YDR315C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:LEM3(YNL323W)|FD-Score:3.14|P-value:8.38E-4||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:PET191(YJR034W)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery Gene:PKH3(YDR466W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PUN1(YLR414C)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress Gene:RAV1(YJR033C)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RIM8(YGL045W)|FD-Score:4.46|P-value:4.02E-6||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL11B(YGR085C)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication Gene:SAC1(YKL212W)|FD-Score:3.88|P-value:5.20E-5||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SDT1(YGL224C)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives Gene:SEC22(YLR268W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SPS19(YNL202W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate Gene:SUR4(YLR372W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis Gene:THO2(YNL139C)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids Gene:TUF1(YOR187W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YHL015W-A(YHL015W-A_p)|FD-Score:4.45|P-value:4.23E-6||SGD DESC:Putative protein of unknown function Gene:YJL147C(YJL147C_p)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene Gene:YMR090W(YMR090W_p)|FD-Score:3.95|P-value:3.94E-5||SGD DESC:Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability Gene:YPR027C(YPR027C_p)|FD-Score:4.02|P-value:2.90E-5||SGD DESC:Putative protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YEL034W6.105.23E-101.20HYP2Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
YCR052W4.904.82E-70.59RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YGL093W4.318.33E-60.31SPC105Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
YMR203W3.993.28E-50.57TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YFR037C3.423.14E-40.07RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YDR187C_d3.354.09E-40.00YDR187C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YJL086C_d3.344.14E-40.25YJL086C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
YHR007C3.099.90E-40.21ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YNL131W2.880.001980.03TOM22Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YDR177W2.850.002200.06UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YGR114C_d2.790.002630.04YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YCR057C2.750.002950.12PWP2Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YHR062C2.630.004250.03RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YNL151C2.600.004640.01RPC31RNA polymerase III subunit C31
YJR006W2.600.004710.08POL31Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML048W8.491.07E-17GSF2ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YNL041C5.344.63E-8COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGL045W4.464.02E-6RIM8Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
YHL015W-A_p4.454.23E-6YHL015W-A_pPutative protein of unknown function
YBR003W4.308.43E-6COQ1Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YJL172W4.289.52E-6CPS1Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YML099C4.251.07E-5ARG81Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
YHR096C4.251.09E-5HXT5Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication
YLR372W4.171.52E-5SUR4Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YPR027C_p4.022.90E-5YPR027C_pPutative protein of unknown function
YMR090W_p3.953.94E-5YMR090W_pPutative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
YKL212W3.885.20E-5SAC1Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
YDL178W3.875.46E-5DLD2D-lactate dehydrogenase, located in the mitochondrial matrix
YLR330W3.768.52E-5CHS5Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
YLR268W3.691.12E-4SEC22R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog

GO enrichment analysis for SGTC_1481
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1763.41E-42SGTC_1098clofazimine 15.1 μMNIH Clinical Collection27940.107527heme biosynthesis & mitochondrial translocase
0.1461.04E-29SGTC_7450469-0705 296.0 μMChemDiv (Drug-like library)34867360.0833333mitochondrial processes
0.1396.40E-27SGTC_31729105863 49.5 μMChembridge (Drug-like library)23487850.190476ERG2
0.1361.15E-25SGTC_22287354201 200.0 μMChembridge (Fragment library)7534510.175676endomembrane recycling
0.1321.94E-24SGTC_14780453-0656 35.7 μMChemDiv (Drug-like library)52584960.0588235
0.1271.77E-22SGTC_1113artemisinin 1.2 μMTimTec (Natural product library)22400.0963855heme biosynthesis & mitochondrial translocase
0.1263.20E-22SGTC_7461095-0025 46.6 μMChemDiv (Drug-like library)67492860.0470588RSC & ERG11
0.1226.19E-21SGTC_20014023502 57.7 μMChembridge (Fragment library)1089410.0821918mitochondrial processes
0.1202.70E-20SGTC_1917st066507 28.5 μMTimTec (Natural product derivative library)31564280.123711Golgi
0.1201.74E-20SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0689655RSC & ERG11
0.1132.55E-18SGTC_690096-0274 206.7 μMChemDiv (Drug-like library)67413920.0864198mitochondrial processes
0.1125.43E-18SGTC_29289011484 9.8 μMChembridge (Drug-like library)29947510.0561798heme biosynthesis & mitochondrial translocase
0.1128.07E-18SGTC_29309013230 14.9 μMChembridge (Drug-like library)29958570.0705882heme biosynthesis & mitochondrial translocase
0.1071.71E-16SGTC_8510394-0702 453.0 μMChemDiv (Drug-like library)7626460.0617284mitochondrial processes
0.1054.72E-16SGTC_2541muurolladie-3-one 83.1 μMMicrosource (Natural product library)39894190.0759494excess fatty acid

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2722naftopidil47.16 μM0.3802824418Miscellaneous392.490723.96215
SGTC_3324913875960.75 μM0.36619745595710Chembridge (Drug-like library)375.333123.75624
SGTC_3341502-102468.5 μM0.3108113296216ChemDiv (Drug-like library)352.469924.07814
SGTC_1673672-005166.21 μM0.3037973237971ChemDiv (Drug-like library)366.49654.56514
SGTC_10174239-0030168 μM0.2972971149593ChemDiv (Drug-like library)406.2919433.78814
SGTC_14823346-20498.48 μM0.2716053826804ChemDiv (Drug-like library)390.516363.84115
SGTC_22216807166181.08 μM0.271429674925Chembridge (Fragment library)274.2902032.47404
SGTC_3046909221249.47 μM0.2702725236637Chembridge (Drug-like library)328.3806433.404
SGTC_14454239-015697.7 μM0.2592594008346ChemDiv (Drug-like library)375.4123263.22816
SGTC_12820886-001032.4 μM0.2560982836211ChemDiv (Drug-like library)445.42456.40112endomembrane recycling